17 completed, 3 withdrawn, 1 not yet recruiting, 1 recruiting. 9 Not applicable, 7 Phase 2, 4 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 4, Withdrawn 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 2 | 7 | Completed 6, Withdrawn 1 |
| Phase 3 | 4 | Completed 4 |
| Phase 1 | 3 | Completed 3 |
Follow Treatment Interruption: new trials by email Literature Review of Treatment Interruption trials Research Report on Treatment Interruption
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of Analytical Treatment Interruption in People With HIV With a Highly Favourable Profile Treatment interruption - HIV | Not applicable | Not yet recruiting | Fundacion Clinic per a la Recerca Biomédica | 20 | 2026-10-01 | 2026-10-15 |
| Exploring Parameters of Driving Simulation in Relation to Drug Holidays in ADHD Patients "drug holidays" (D) - ADHD - Attention Deficit Disorder With Hyperactivity, Driving Simulator Performance | Not applicable | Recruiting | Stefan Lakämper | 26 | 2025-06-02 | 2025-06-05 |
| Sleep/Wake State Assessment with Non-invasive Earbuds NextSense EEG-enabled earbuds, Ellcie Healthy eyeglasses, Drug Holiday - Hypersomnolence | Not applicable | Completed | Emory University | 8 | 2021-10-13 | 2025-02-11 |
| Viral Suppression After Analytic Treatment Interruption in Thai Patients Who Initiated Highly Active Antiretroviral Therapy During Acute HIV Infection Treatment interruption - Acute HIV Infection, Antiretroviral Treatment Interruption | Not applicable | Completed | SEARCH Research Foundation | 8 | 2016-02-01 | 2017-01-27 |
| A Study of the Safety and Antiretroviral Activity of 3BNC117 3BNC117, Antiretroviral Treatment Interruption - HIV-1 Infection | Phase 2 | Completed | Rockefeller University | 17 | 2015-10-01 | 2021-06-16 |
| 3BNC117 Monoclonal Antibody in HIV-infected Subjects During Treatment Interruption 3BNC117, ART Interruption - HIV-1 Infection | Phase 2 | Completed | Rockefeller University | 16 | 2015-03-11 | 2020-07-23 |
| Structured Treatment Interruption (STI) in Acute/Primary HIV Gradual anti-HIV treatment interruption - HIV Infections | Not applicable | Unknown | Tel-Aviv Sourasky Medical Center | 10 | 2011-02-01 | 2011-02-10 |
| Continuing vs Intermittent Trabectedin in Patients With Advanced Soft Tissue Sarcoma Trabectedin, Drug: holiday - Soft Tissue Sarcoma, Uterine Sarcoma | Phase 2 | Completed | Centre Oscar Lambret | 53 | 2011-02-01 | 2026-03-16 |
| Novel Approach to Stimulant Induced Weight Suppression and Its Impact on Growth behavior therapy, Extended release (ER) methylphenidate product, monitoring - ADHD, Growth | Phase 3 | Completed | Florida International University | 230 | 2010-11-01 | 2017-07-14 |
| Redirected High Affinity Gag-Specific Autologous T Cells for HIV Gene Therapy WT-gag-TCR modified T cells, α/6-gag-TCR modified T cells, STI or Drug Holiday - HIV Infections | Phase 1 | Completed | University of Pennsylvania | 2 | 2009-11-01 | 2019-10-10 |
| Early and Intermittent Antiretroviral Therapy in Naive HIV Infected Adults Structured treatment interruption - HIV Infections | Phase 2 | Completed | ANRS, Emerging Infectious Diseases | 45 | 2009-05-01 | 2026-04-07 |
| Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases SB-728 for HIV ZFN modified T cells, Structured Treatment Interruption - HIV, HIV Infections | Phase 1 | Completed | University of Pennsylvania | 12 | 2009-01-01 | 2019-02-08 |
| Anti-HIV Treatment Interruptions in HIV Infected Adults in South Africa Structured treatment interruption, Lamivudine, Lopinavir/Ritonavir - HIV Infections | Not applicable | Completed | The Wistar Institute | 30 | 2007-03-01 | 2014-08-27 |
| Phase II/III Study Evaluating the Effect of IL-2 on Preservation of the CD4 T-Lymphocytes After Interruption of Antiretroviral Treatment in HIV-Infected Patients With CD4 T-Lymphocyte Count Greater Than 500 Cells/mm3 Who Received Antiretroviral Tx Interleukin 2, HAART, Treatment interruption - HIV Infections | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 148 | 2003-10-01 | 2010-10-05 |
| Treatment Plan to Decrease Drug Exposure in HIV Infected Adolescents Structured treatment interruption - HIV Infections | Not applicable | Withdrawn | University of North Carolina, Chapel Hill | 2003-07-01 | 2017-03-06 | |
| Long-Term Supervised Treatment Interruption in HIV-Infected Patients Treatment interruption - HIV Infections | Phase 3 | Completed | French National Agency for Research on AIDS and Viral Hepatitis | 130 | 2003-02-01 | 2007-08-30 |
| Randomised Trial of Structured Treatment Interruption of HAART in HIV-Infected Adults in Abidjan (ANRS 1269 TRIVACAN) Structured Treatment Interruption, Zidovudine (ZDV), Lamivudine (3TC) - HIV Infections | Phase 3 | Completed | French National Agency for Research on AIDS and Viral Hepatitis | 840 | 2002-12-01 | 2008-12-30 |
| Staccato: A Trial of CD4 Guided Treatment Interruption, Compared to Continuous Treatment, for HIV Infection Treatment interruption - HIV Infection, AIDS | Not applicable | Completed | University Hospital, Geneva | 526 | 2002-01-01 | 2006-11-29 |
| BASTA Study on STI in HIV Infected Patients STI (structured Treatment Interruption) - HIV Infection | Phase 3 | Completed | A.O. Ospedale Papa Giovanni XXIII | 130 | 2000-11-01 | 2006-07-24 |
| Immune and Viral Outcomes of HIV-1 Therapy Interruption Treatment interruption/reinitiation schedule - HIV Infections | Phase 1 | Completed | The Wistar Institute | 20 | 2000-09-01 | 2016-02-09 |
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HIV Infections (15) · Attention Deficit Disorder with Hyperactivity (2) · Acquired Immunodeficiency Syndrome (1) · Disorders of Excessive Somnolence (1) · Idiopathic Hypersomnia (1) · Sarcoma (1) · Sexually Transmitted Diseases (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · French National Agency for Research on AIDS and Viral Hepatitis (2) · Rockefeller University (2) · The Wistar Institute (2) · University of Pennsylvania (2) · A.O. Ospedale Papa Giovanni XXIII (1) · ANRS, Emerging Infectious Diseases (1) · Centre Oscar Lambret (1) · Emory University (1) · Florida International University (1) · Fundacion Clinic per a la Recerca Biomédica (1) · SEARCH Research Foundation (1) · Stefan Lakämper (1) · Tel-Aviv Sourasky Medical Center (1) · University Hospital, Geneva (1)
United States (10) · France (4) · Switzerland (2) · Côte d’Ivoire (1) · Italy (1) · South Africa (1) · Thailand (1)
Marina Caskey, MD (2) · Bernard Hirschel, MD (1) · Christine Danel, MD (1) · Christophe Piketti, MD (1) · Craig M Wilson, MD (1) · David Haas (1) · David Rye, MD, PhD (1) · David Stein, MD (1) · Dominique Costagliola (1) · Don Smith, MB, ChB, MD (1) · Emmanuel Bissagnene, Pr (1) · Eric Rosenberg, MD (1) · Franco Maggiolo, MD (1) · Fred Valentine (1) · Ian M. Sanne, MBBCH, FCP(SA), DTM&H (1)
PMID 14571185, PMID 15090796, PMID 15630469, PMID 16782488, PMID 16890832, PMID 18339636, PMID 18986246, PMID 19425222, PMID 20657770, PMID 20822522, PMID 21274424, PMID 21738668, PMID 21801351, PMID 24597865, PMID 25680558, PMID 26568566, PMID 31473291, PMID 34049356, PMID 34366928, PMID 34571023, PMID 38819800
2008 (1), R01AI051986 (1), U01AI118536 (1)