22 completed, 3 terminated, 2 unknown, 1 withdrawn. 28 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Completed 22, Terminated 3, Unknown 2, Withdrawn 1 |
Follow Travoprost: new trials by email Literature Review of Travoprost trials Research Report on Travoprost
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3 Study Evaluating Safety and Efficacy of OTX-TP in Subjects With OAG or OHT Travoprost, Placebo Vehicle - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Ocular Therapeutix, Inc. | 565 | 2016-11-07 | 2021-10-11 |
| Stop Retinal Ganglion Cell Dysfunction Study Latanoprost, Bimatoprost, Travoprost - Glaucoma | Phase 3 | Terminated | University of Miami | 28 | 2015-09-01 | 2025-08-26 |
| Study of Travoprost Ophthalmic Solution, 0.004% Compared to Timolol (0.5% or 0.25%) in Pediatric Glaucoma Patients Travoprost 0.004% PQ ophthalmic solution, Timolol, 0.5% or 0.25% ophthalmic solution, Travoprost Vehicle - Pediatric Glaucoma, Elevated IOP in Pediatric Patients | Phase 3 | Completed | Alcon Research | 184 | 2012-09-01 | 2015-07-23 |
| Travoprost 3-Month Safety and Efficacy Study Travoprost ophthalmic solution, 0.003%, Travoprost ophthalmic solution, 0.004% - Open-Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 1099 | 2011-11-01 | 2013-10-18 |
| Three Month Safety and Efficacy Study of TRAVATAN® Versus Travoprost Ophthalmic Solution, 0.004% Travoprost Ophthalmic Solution, 0.004% (New Formulation), TRAVATAN® - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Withdrawn | Alcon Research | 2011-11-01 | 2012-02-10 | |
| Travoprost 0.004%/Timolol 0.5% Versus Latanoprost 0.005%/Timolol in Chinese Patients With Open-Angle Glaucoma or Ocular Hypertension Travoprost 0.004%/Timolol 0.5%, Latanoprost 0.005% / Timolol 0.5% - Open-angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 242 | 2010-01-01 | 2013-03-28 |
| Safety Study of DuoTrav APS in Patients With Open-Angle Glaucoma or Ocular Hypertension Travoprost/Timolol Maleate Fixed Combination solution - Open-angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 155 | 2009-07-01 | 2014-07-18 |
| Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma Selective Laser Trabeculoplasty, Travoprost/ Timolol/ Azopt/ Brimonidine - Glaucoma | Phase 3 | Unknown | Singapore Eye Research Institute | 90 | 2009-06-01 | 2010-05-12 |
| Efficacy Study of Travoprost APS Versus TRAVATAN Travoprost 0.004% (POLYQUAD-preserved) Eye Drops, Solution, Travoprost 0.004% (BAK-preserved) Eye Drops, Solution - Open Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 371 | 2009-03-01 | 2012-04-06 |
| Travoprost/Brinzolamide Fixed Combination Versus Travatan and Versus AZOPT Travoprost/Brinzolamide fixed combination, Azopt, Travatan - Glaucoma, Ocular Hypertension | Phase 3 | Terminated | Alcon Research | 17 | 2008-10-01 | 2012-09-19 |
| Phase III Clinical Trial of TRAVATAN Z in Ocular Surface Health Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®), Latanoprost ophthalmic solution 0.005% (XALATAN®) - Open-angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 705 | 2008-10-01 | 2012-04-26 |
| 1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT Travoprost/Brinzolamide, Cosopt - Glaucoma, Ocular Hypertension | Phase 3 | Terminated | Alcon Research | 6 | 2008-10-01 | 2012-07-19 |
| Travatan Z in Ocular Surface Health in Patients With Open-Angle Glaucoma or Ocular Hypertension Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®), Latanoprost ophthalmic solution 0.005% (XALATAN®) - Open-angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 726 | 2008-07-01 | 2012-07-24 |
| Safety and Efficacy of Travoprost/Timolol BAC-free Travoprost 0.004%/Timolol 0.5% BAC-free ophthalmic solution, Travoprost 0.004%/Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 87 | 2008-06-01 | 2014-07-16 |
| A Phase III Study of Travoprost/Timolol Combination in Patients With Open-Angle Glaucoma or Ocular Hypertension Travoprost 0.004%/Timolol 0.5% BAC-free ophthalmic solution, Travoprost 0.004%/Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 301 | 2008-05-01 | 2014-07-16 |
| Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma Argon Laser Iridoplasty, Travatan/ Timolol/Azopt - Glaucoma | Phase 3 | Unknown | Singapore National Eye Centre | 80 | 2007-09-01 | 2011-06-17 |
| A Phase IIIb Study of DuoTrav to Treat Glaucoma or Ocular Hypertension Travoprost 0.004%/timolol 0.5% ophthalmic solution, Travoprost ophthalmic solution, 0.004%, Timolol maleate ophthalmic solution, 0.5% - Open-angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 81 | 2007-03-01 | 2014-07-24 |
| A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension Travoprost 40 mcg/ml + Timolol 5 mg/ml eye drops, solution (DuoTrav), Dorzolamide 20 mg/ml + Timolol 5 mg/ml eye drops, solution (Cosopt), Timolol Vehicle - Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 319 | 2006-04-01 | 2016-11-18 |
| 24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination travoprost/timolol fixed combination, placebo (artificial tears) - Primary Open Angle Glaucoma, Exfoliation Syndrome | Phase 3 | Completed | Aristotle University Of Thessaloniki | 32 | 2006-03-01 | 2014-05-12 |
| A Study of Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension Travoprost, Investigational, Travoprost (TRAVATAN) - Open-angle Glaucoma, Ocular Hypertension | Phase 3 | Completed | Alcon Research | 109 | 2006-01-01 | 2016-11-18 |
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Ocular Hypertension (24) · Glaucoma, Open-Angle (21) · Glaucoma (17) · Hypertension (5) · Glaucoma, Angle-Closure (2) · Exfoliation Syndrome (1) · Hydrophthalmos (1)
Alcon Research (23) · Aristotle University Of Thessaloniki (1) · Ocular Therapeutix, Inc. (1) · Singapore Eye Research Institute (1) · Singapore National Eye Centre (1) · University of Miami (1)
United States (7) · Belgium (2) · Singapore (2) · Australia (1) · China (1) · Greece (1) · Japan (1) · Mexico (1)
Pamela Smith, B.S. (2) · Subha Venkataraman, Clinical Project Lead (1) · Theresa A Landry, PhD (1) · Theresa Landry (1) · Theresa Landry, Ph.D (1) · Tin Aung, FRCOphth (1) · Vittorio Porciattti, DSc (1)
PMID 18414108, PMID 25429421, PMID 27450828, PMID 2788589
2008 (2), R01EY014957 (1)