43 completed. 43 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 43 | Completed 43 |
Follow Timolol: new trials by email Literature Review of Timolol trials Research Report on Timolol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Efficacy and Ocular Surface Assessment Between BRIDIN-plus and Combigan in Glaucoma or Ocular Hypertensive BRIDIN-plus Eye drops, Combigan Eye drops - Glaucoma, Ocular Hypertensive | Phase 4 | Completed | CHA University | 60 | 2021-10-08 | 2025-03-26 |
| Aqueous Humor Dynamic Components That Determine Intraocular Pressure Variance Timolol 0.5% ophthalmic solution, Latanoprost 0.005% Ophthalmic Solution - Glaucoma, OHT - Ocular Hypertension | Phase 4 | Completed | Ohio State University | 59 | 2020-11-23 | 2026-03-04 |
| Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Timolol Maleate, Brimonidine Tartrate - Glaucoma; Drugs, Normal Tension Glaucoma | Phase 4 | Completed | Wills Eye | 35 | 2017-07-10 | 2020-12-31 |
| 24-hour Efficacy and Ocular Surface With Talfuprost and Triple Combined Therapy tafluprost, tafluprost and dorzolamide/timolol - Glaucoma, Ocular Surface Disease | Phase 4 | Completed | Aristotle University Of Thessaloniki | 43 | 2015-03-01 | 2020-12-17 |
| Comparison of Intraocular Pressure (IOP)-Lowering Efficacy and Safety of AZORGA® Ophthalmic Suspension and COSOPT® Ophthalmic Solution Brinzolamide 1%/Timolol maleate 0.5% fixed combination ophthalmic suspension, Dorzolamide hydrochloride 1%/Timolol maleate 0.5% ophthalmic solution, Subject's habitual PGA monotherapy - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon, a Novartis Company | 218 | 2014-12-01 | 2016-12-08 |
| Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension bimatoprost 0.01%, travoprost 0.004%, timolol 0.5% - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Allergan | 100 | 2014-05-01 | 2016-01-14 |
| Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma Brimonidine Tartrate, Dorzolamide (as Dorzolamide Hydrochloride) 20 Mg/mL and Timolol (as Timolol Maleate) 5 Mg/mL Eye Drops, Brinzolamide/Timolol 10 MG/1 ML-5 MG/1 ML Ophthalmic Suspension - Glaucoma, Open-Angle | Phase 4 | Completed | Afyon Kocatepe University Hospital | 96 | 2014-01-01 | 2019-05-29 |
| Efficacy of Travoprost/Timolol for Uncontrolled Intraocular Pressure Beta-blocker monotherapy, Travoprost 0.004% / timolol 0.5% fixed combination ophthalmic solution - Open Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 157 | 2013-12-01 | 2016-08-08 |
| Evaluation of Intraocular Pressure Using Simbrinza™ in Patients With Open-Angle Glaucoma or Ocular Hypertension Brinzolamide 1%/Brimonidine 0.2% ophthalmic suspension, Timolol Maleate 0.5% - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 89 | 2013-10-01 | 2015-04-13 |
| An Efficacy and Safety Study of Bimatoprost 0.01% Alone Compared With Travoprost 0.004% and Timolol 0.5% in Subjects With Glaucoma or Ocular Hypertension bimatoprost 0.01%, travatan 0.004%, timolol 0.5% - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Allergan | 93 | 2013-06-01 | 2015-11-30 |
| Safety and Efficacy of LUMIGAN® RC Versus DuoTrav® in Patients Who Require Further Intraocular Pressure (IOP) Reduction travoprost ophthalmic solution 0.004%, travoprost 0.004% / timolol 0.5% combination ophthalmic solution, Bimatoprost ophthalmic solution 0.01% - Glaucoma, Open-Angle, Ocular Hypertension | Phase 4 | Completed | Allergan | 135 | 2011-12-01 | 2014-08-15 |
| Efficacy and Tolerability of AZARGA® as Replacement Therapy in Patients on COMBIGAN® Therapy in Canada Brinzolamide 1% / timolol 0.5% maleate fixed combination - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 57 | 2011-09-01 | 2014-07-01 |
| Patient Preference Comparison of AZARGA Versus COSOPT Brinzolamide 1.0% + Timolol 0.5% ophthalmic suspension, Dorzolamide 2.0% + Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 112 | 2011-09-01 | 2014-02-10 |
| Efficacy of Changing to DUOTRAV® From Prior Therapy Travoprost 0.004%+Timolol 0.5% ophthalmic solution - Open-Angle Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 60 | 2011-08-01 | 2014-02-10 |
| AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure Brinzolamide 1% and timolol 0.5% fixed combination eye drops - Glaucoma | Phase 4 | Completed | Alcon Research | 74 | 2011-05-01 | 2013-05-01 |
| Safety and Efficacy of Adding AZARGA® Adjunctive to Prostaglandin Therapy Brinzolamide 1% / timolol 0.5% Fixed Combination, Habitual prostaglandin monotherapy - Glaucoma, Ocular Hypertension | Phase 4 | Completed | Alcon Research | 47 | 2011-03-01 | 2014-05-20 |
| Safety and Efficacy of Changing to DuoTrav in Patients Uncontrolled on Timolol Travoprost 0.004%/timolol maleate 0.5% fixed combination - Glaucoma | Phase 4 | Completed | Alcon Research | 50 | 2011-02-01 | 2013-07-08 |
| Safety and Efficacy of Changing to DuoTrav From Prior Therapy Travoprost 0.004%/Timolol 0.5% Fixed Combination eye drops solution (Duotrav®) - Glaucoma | Phase 4 | Completed | Alcon Research | 105 | 2010-10-01 | 2016-11-21 |
| Safety and Efficacy of Bimatoprost/Timolol Fixed Combination Versus Latanoprost in Patients With Open-Angle Glaucoma Who Have Never Been Treated bimatoprost 0.03%/timolol 0.5% combination ophthalmic solution, latanoprost 0.005% ophthalmic solution - Glaucoma, Open-Angle | Phase 4 | Completed | Allergan | 81 | 2010-06-01 | 2019-04-18 |
| 24-Hour Intraocular Pressure Control With Bimatoprost/Timolol Versus Latanoprost as First Choice Bimatoprost/Timolol, 24-hour intraocular pressure monitoring, Latanoprost, 24-hour intraocular pressure monitoring - Glaucoma | Phase 4 | Completed | Aristotle University Of Thessaloniki | 37 | 2010-04-01 | 2014-05-12 |
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Glaucoma (26) · Glaucoma, Open-Angle (25) · Ocular Hypertension (25) · Eye Diseases (3) · Exfoliation Syndrome (1) · Low Tension Glaucoma (1) · Patient Compliance (1)
Alcon Research (13) · Allergan (9) · Aristotle University Of Thessaloniki (4) · Pharmaceutical Research Network (3) · Bp Consulting, Inc (2) · Afyon Kocatepe University Hospital (1) · Alcon, a Novartis Company (1) · CHA University (1) · Glaukos Corporation (1) · Maisonneuve-Rosemont Hospital (1) · Ohio State University (1) · Taiwan Otsuka Pharm. Co., Ltd (1) · University of California, Los Angeles (1) · University of Michigan (1) · University of Parma (1)
United States (17) · Canada (7) · Greece (4) · Germany (3) · Spain (3) · Italy (2) · Armenia (1) · Austria (1) · France (1) · Japan (1) · Poland (1) · Portugal (1) · Slovenia (1) · South Korea (1) · Taiwan (1)
William C. Stewart, MD (4) · Anastasios G Konstas, MD, PhD (2) · Elizabeth D. Sharpe, MD (2) · Severine Durier, Pharm.D (2) · Abayomi Ogundele, PharmD (1) · Anastasios GP Konstas, MD, PhD (1) · Anastasios Konstas, MD, phD (1) · Barbara Cvenkel, MD (1) · Cindy M. Hutnik, BSc, PhD, MD (1) · Da-Wen Lu, MD/PhD (1) · Daniel Lee, MD (1) · Danyel C. Carr, MS, CCRA (1)
PMID 19476406, PMID 12614754, PMID 14509472, PMID 16303952, PMID 17102003, PMID 20505839, PMID 21773673, PMID 21960068, PMID 22458918, PMID 24855336, PMID 27913991, PMID 28239491, PMID 40341017, PMID 8562550
2009 (1), R01EY022124 (1)