27 completed. 27 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 27 | Completed 27 |
| Phase 2 | 4 | Completed 4 |
Follow Tenecteplase: new trials by email Literature Review of Tenecteplase trials Research Report on Tenecteplase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endovascular Treatment With or Without Preceding Intravenous Tenecteplase (TNK) in Patients With Late-window acUte Ischemic Stroke Due to Middle Cerebral Artery Occlusion Tenecteplase, direct EVT - Ischemic Stroke, Acute, Thrombolysis | Phase 3 | Completed | Beijing Tiantan Hospital | 391 | 2024-01-25 | 2025-11-26 |
| Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events-5 Tenecteplase, Best Practice (which may include intravenous Alteplase) - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 452 | 2024-01-24 | 2025-11-26 |
| Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion Intravenous thrombolysis, Endovascular thrombectomy - Basilar Artery Occlusion, Acute Cerebrovascular Accident | Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 338 | 2023-05-09 | 2026-08-12 |
| Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II) Tenecteplase - Stroke, Ischemic | Phase 3 | Completed | General Hospital of Shenyang Military Region | 380 | 2023-03-21 | 2025-03-28 |
| Safety and Efficacy of Intra-arterial Tenecteplase for Noncomplete Reperfusion of Intracranial Occlusions Tenecteplase - Ischemic Stroke | Phase 3 | Completed | Insel Gruppe AG, University Hospital Bern | 156 | 2023-03-21 | 2026-02-10 |
| Rescue Thrombolysis for Medium Vessel Occlusion (RESCUE-TNK) Tenecteplase - Stroke, Ischemic | Phase 2 / Phase 3 | Completed | General Hospital of Shenyang Military Region | 80 | 2023-03-21 | 2025-06-17 |
| Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion Tenecteplase, Endovascular thrombectomy - Basilar Artery Occlusion, Acute Cerebrovascular Accident | Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 330 | 2023-03-16 | 2026-02-18 |
| Intra-arterial TNK Following Endovascular Thrombectomy in Patients With Large Vessel Occlusion of Posterior Circulation Tenecteplase, endovascular thrombectomy alone - Acute Ischemic Stroke, Intracranial Artery Occlusion | Phase 2 / Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 208 | 2023-01-24 | 2024-04-11 |
| Endovascular Treatment With Versus Without Intravenous rhTNK-tPA in Stroke rhTNK-tPA, Endovascular treatment - Stroke, Acute, Stroke, Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 550 | 2022-05-09 | 2025-04-03 |
| Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-III tenecteplase (0.25 mg/kg, Max 25 mg), standard medical treatment - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 516 | 2022-01-19 | 2024-04-30 |
| Study of Efficacy and Safety of GNR-060 vs Metalyse in Patients With ST Elevation Myocardial Infarction GNR-060, Metalyse - ST Elevation Myocardial Infarction | Phase 3 | Completed | AO GENERIUM | 244 | 2021-09-03 | 2026-09-21 |
| A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity tenecteplase, alteplase - Stroke | Phase 3 | Completed | Boehringer Ingelheim | 1489 | 2021-06-22 | 2024-12-10 |
| TENecteplase in Central Retinal Artery Occlusion Stuy (TenCRAOS) Intravenous injection of Tenecteplase and one dose of placebo tablet, One tablet of Acetylsalicylic Acid and one dose of IV placebo - Central Retinal Artery Occlusion | Phase 3 | Completed | Oslo University Hospital | 81 | 2020-10-30 | 2025-09-29 |
| Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke Tenecteplase, Alteplase - Stroke, Acute, Thromboses, Intracranial | Phase 3 | Completed | University of Calgary | 1600 | 2019-12-10 | 2023-05-12 |
| Tenecteplase in Stroke Patients Between 4.5 and 24 Hours Tenecteplase, Placebo - THROMBOLYSIS | Phase 3 | Completed | Genentech, Inc. | 458 | 2019-03-02 | 2024-05-22 |
| Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis Intravenous recombinant tissue plasminogen activator (rtPA) Alteplase, Intravenous Tenecteplase - Ischemic Stroke | Phase 3 | Completed | NHS Greater Glasgow and Clyde | 1858 | 2016-12-15 | 2024-06-13 |
| A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion Tenecteplase, Antiplatelet treatment - Stroke, Acute | Phase 3 | Completed | University of Calgary | 1274 | 2015-04-01 | 2025-01-31 |
| Single Bolus Recombinant Nonimmunogenic Staphylokinase Versus Single Bolus Tenecteplase (Metalyse) in STEMI Recombinant staphylokinase, Tenecteplase - Myocardial Infarction | Phase 3 | Completed | Supergene, LLC | 382 | 2014-05-16 | 2025-03-20 |
| Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic Stroke Tenecteplase, Alteplase - Ischemic Stroke | Phase 3 | Completed | Lars Thomassen | 1050 | 2012-09-01 | 2017-05-09 |
| STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction primary PCI, enoxaparin, catheterisation - Myocardial Infarction | Phase 3 | Completed | Boehringer Ingelheim | 1899 | 2008-03-01 | 2019-08-01 |
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Ischemic Stroke (10) · Stroke (6) · Myocardial Infarction (5) · Hemorrhage (2) · ST Elevation Myocardial Infarction (2) · Coronary Thrombosis (1) · Hemorrhagic Stroke (1) · Infarction, Middle Cerebral Artery (1) · Intracranial Thrombosis (1) · Myocardial Ischemia (1) · Pulmonary Embolism (1) · Renal Insufficiency (1) · Retinal Artery Occlusion (1)
Genentech, Inc. (5) · Beijing Tiantan Hospital (3) · Boehringer Ingelheim (3) · The First Affiliated Hospital of University of Science and Technology of China (3) · General Hospital of Shenyang Military Region (2) · University of Calgary (2) · AO GENERIUM (1) · Assistance Publique - Hôpitaux de Paris (1) · Insel Gruppe AG, University Hospital Bern (1) · Lars Thomassen (1) · NHS Greater Glasgow and Clyde (1) · Oslo University Hospital (1) · Supergene, LLC (1) · University of Alberta (1) · Xinqiao Hospital of Chongqing (1)
China (10) · Canada (5) · Austria (4) · Belgium (4) · Finland (3) · Germany (3) · Norway (3) · Russia (3) · Spain (3) · United Kingdom (3) · Brazil (2) · France (2) · Greece (2) · Italy (2) · Poland (2)
Barbara Gillespie, M.D., FASN (2) · Wei Hu, MD (2) · Barbara Gillespie, MD, FASN (1) · Bijoy K Menon, MD (1) · Bruce Campbell, MD, PhD (1) · Fana Alemseged, MD, PhD (1) · Fengyuan Che, MD (1) · Jeffrey L Saver, MD (1) · Keith Muir, MD, FRCP (1) · Lars Thomassen, MD PhD Prof. (1) · Michael D Hill, MD (1) · Nicola Logallo, MD PhD (1) · Oksana A. Markova, MD, MSc (1)
PMID 26387127, PMID 15262836, PMID 20133491, PMID 20598969, PMID 21111365, PMID 21315210, PMID 22172434, PMID 23473396, PMID 24716681, PMID 24916050, PMID 25161043, PMID 25691510, PMID 26304934, PMID 26783237, PMID 28335835, PMID 28525886, PMID 28780236, PMID 30602354, PMID 31009339, PMID 32511749, PMID 32631157, PMID 33464335, PMID 33857326, PMID 34564893, PMID 35262424, PMID 35369714, PMID 35779553, PMID 37247876, PMID 37800372, PMID 37830342, PMID 38124230, PMID 38174568, PMID 38275116, PMID 38329148, PMID 38676572, PMID 38768626, PMID 38884324, PMID 39264623, PMID 39379314, PMID 39424558, PMID 39435713, PMID 39567366, PMID 39689189, PMID 39809509, PMID 39952376, PMID 40123483, PMID 40396577, PMID 40674670, PMID 40677228, PMID 41143808
2018 (1)