5 unknown, 4 completed, 1 not yet recruiting, 1 withdrawn. 4 Phase 3, 4 Phase 4, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Not yet recruiting 1, Unknown 1 |
| Phase 4 | 4 | Unknown 2, Completed 1, Withdrawn 1 |
| Not applicable | 2 | Unknown 2 |
Follow temocillin: new trials by email Literature Review of temocillin trials Research Report on temocillin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Temocillin Compared to Standard of Care in the Treatment of Neisseria Gonorrhoeae Infections Temocillin (NEGABAN®) 2 g intravenous with lidocaine (3ml), Rectal swab for ESBL-E and microbiota (Eswab), Temocillin (NEGABAN®) 2 g intramuscular single dose with lidocaine (3ml) - Neisseria Gonorrhoeae (Ng) Infections | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 360 | 2026-09-01 | 2026-06-22 |
| Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care Unit Piperacillin/tazobactam or temocillin, Meropenem - Sepsis, Septic Shock | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 600 | 2023-03-11 | 2023-04-18 |
| Temocillin in ESBL-Enterobacteriaceae Infections Temocillin - Infectious Disease | Completed | Assistance Publique - Hôpitaux de Paris | 29 | 2022-10-20 | 2023-02-06 | |
| Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins Temocillin, Meropenem - Bacteremia | Phase 3 | Completed | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla | 334 | 2020-12-15 | 2026-01-23 |
| Plasma Protein Binding and PK/PD of Total and Unbound Temocillin Non-ICU Patients temocillin - Pharmacokinetics, Antibacterial Agents | Not applicable | Unknown | Paul M. Tulkens | 60 | 2019-04-01 | 2022-05-31 |
| Temocillin Versus a Carbapenem as Initial Intravenous Treatment for ESBL Related Urinary Tract Infections Temocillin, meropenem or imipenem - Urinary Tract Infections | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 29 | 2019-01-04 | 2025-11-20 |
| Population Pharmacokinetics and Pharmacodynamics of Beta-lactams of Interest in Adult Patients From Intensive Care Units blood sampling, Tissue sampling (lung), Collection of fluid samples - Pharmacokinetics, Anti-Bacterial Agents | Not applicable | Unknown | Université Catholique de Louvain | 20 | 2018-03-15 | 2022-05-25 |
| Disturbance of the Intestinal Microbiota by Temocillin vs Cefotaxime in Treatment of Febrile Urinary Tract Infections Temocillin, Cefotaxime - Urinary Tract Infections | Phase 4 | Completed | Håkan Hanberger | 157 | 2016-05-20 | 2019-09-16 |
| Efficacy of Temocillin in Urinary Tract Infection Due to ESBL Producing and AmpC Hyperproducing Enterobacteriaceae Temocillin - Urinary Tract Infections | Phase 4 | Unknown | University Hospital, Grenoble | 25 | 2016-04-01 | 2018-06-06 |
| Temocillin Pharmacokinetics in Paediatrics Temocillin - Infection, Liver Dysfunction | Phase 4 | Unknown | Université Catholique de Louvain | 45 | 2016-02-17 | 2022-05-31 |
| Temocillin Use in Complicated Urinary Tract Infections Due to Extended Spectrum Beta-Lactamases (ESBL)/AmpC Enterobacteriaceae Temocillin - Urinary Tract Infection | Phase 4 | Withdrawn | Belpharma s.a. | 2012-02-01 | 2013-01-29 |
Urinary Tract Infections (6) · Infections (5) · Bacterial Infections (2) · Toxemia (2) · Bacteremia (1) · Communicable Diseases (1) · Gonorrhea (1) · Liver Diseases (1) · Respiratory Tract Infections (1) · Sepsis (1) · Sexually Transmitted Diseases (1) · Shock, Septic (1)
Assistance Publique - Hôpitaux de Paris (4) · Université Catholique de Louvain (2) · Belpharma s.a. (1) · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (1) · Håkan Hanberger (1) · Paul M. Tulkens (1) · University Hospital, Grenoble (1)
France (5) · Belgium (3) · Spain (1) · Sweden (1) · United Kingdom (1)
Isabelle Bonnet, MD (1) · Paul M. Tulkens, MD, PhD (1) · Peter M Hawkey, Professor (1) · Sophie Vimont, MD (1)
PMID 16531428, PMID 16640454, PMID 19095679, PMID 19237886, PMID 21142293, PMID 22194591, PMID 22839761, PMID 23153962, PMID 24080664, PMID 25712752, PMID 25808018, PMID 26414659, PMID 26603304, PMID 3588249, PMID 1444289, PMID 1482149, PMID 16304153, PMID 17135183, PMID 17846133, PMID 18788687, PMID 19398460, PMID 20561826, PMID 21730935, PMID 21788467, PMID 21810837, PMID 2186240, PMID 21862409, PMID 21914174, PMID 23642005, PMID 24731745, PMID 24768475, PMID 25220556, PMID 25433006, PMID 25455853, PMID 25753628, PMID 26188037, PMID 34580096, PMID 38985543, PMID 42425122, PMID 6305263, PMID 9455502
2015 (2), 2008 (1), 2017 (1), 2025 (1)