22 completed, 1 terminated. 23 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 23 | Completed 22, Terminated 1 |
| Phase 2 | 1 | Terminated 1 |
Follow telaprevir: new trials by email Literature Review of telaprevir trials Research Report on telaprevir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Drug Interaction Study of the Effects of PPI-668 on the Pharmacokinetics of Midazolam and Omeprazole PPI-668, Midazolam, Omeprazole - Pharmacokinetic Assessments in Healthy Volunteers | Phase 1 | Completed | Presidio Pharmaceuticals, Inc. | 24 | 2013-02-01 | 2013-03-26 |
| An Open-Label Study of the Effect of Telaprevir in Combination With Peginterferon Alfa-2b and Ribavirin in Pediatric Subjects Infected With Hepatitis C Virus Telaprevir, Peginterferon alfa-2b, Ribavirin - Hepatitis C | Phase 1 / Phase 2 | Terminated | Vertex Pharmaceuticals Incorporated | 42 | 2013-01-01 | 2016-07-20 |
| Viral Kinetics in HCV Clearance in Subjects With Hemophilia PegInterferon, Ribavirin, Telaprevir - Chronic Hepatitis C, Hemophilia | Phase 1 | Completed | Kenneth Sherman | 5 | 2012-12-01 | 2015-04-06 |
| Eltrombopag/Boceprevir and Eltrombopag/Telaprevir Drug-Drug Interaction Study In Healthy Adult Subjects Eltrombopag, Boceprevir, Telaprevir - Thrombocytopaenia | Phase 1 | Completed | GlaxoSmithKline | 56 | 2012-08-01 | 2017-11-13 |
| Estimate the Effect of Telaprevir and Boceprevir on Maraviroc Pharmacokinetics in Healthy Subjects Maraviroc, Maraviroc + Boceprevir, Maraviroc + Telaprevir - Healthy | Phase 1 | Completed | ViiV Healthcare | 14 | 2012-07-01 | 2012-09-19 |
| Drug Interaction Study to Assess the Effect of Co-Administered Miravirsen and Telaprevir in Healthy Subjects Miravirsen sodium, Telaprevir - Hepatitis C, Chronic Hepatitis C | Phase 1 | Completed | Santaris Pharma A/S | 5 | 2012-06-01 | 2012-11-12 |
| A Study to Assess Safety and Pharmacokinetics of Telaprevir in Patients With Hepatic Impairment telaprevir - Hepatic Impairment | Phase 1 | Completed | Janssen Infectious Diseases BVBA | 24 | 2012-06-01 | 2013-11-11 |
| A Study to Investigate the Potential Pharmacokinetic Interactions Between Phenytoin or Carbamazepine and Telaprevir Telaprevir, Phenytoin, Carbamazepine - Healthy Participants | Phase 1 | Completed | Janssen Infectious Diseases BVBA | 24 | 2012-05-01 | 2013-10-24 |
| A Study to Evaluate the Effect of Boceprevir and Telaprevir on Dolutegravir Pharmacokinetics in Healthy Adult Subjects (ING115697). DTG, BCV, TVR - Infection, Human Immunodeficiency Virus | Phase 1 | Completed | ViiV Healthcare | 32 | 2012-03-01 | 2017-03-28 |
| TMC125IFD1001 - Drug-Drug Interaction of Etravirine With Telaprevir and TMC278 With Telaprevir. ETR/telaprevir, TMC278/telaprevir, telaprevir/ETR - Hepatitis C, HIV | Phase 1 | Completed | Tibotec Pharmaceuticals, Ireland | 33 | 2011-03-01 | 2012-08-29 |
| Drug-Drug Interaction Study Between Telaprevir and Buprenorphine telaprevir, buprenorphine/naloxone - Hepatitis C, Opioid-Related Disorders | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 16 | 2011-01-01 | 2011-06-08 |
| A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults telaprevir, cyclosporine, tacrolimus - Hepatitis C | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 20 | 2010-01-01 | 2010-04-08 |
| VX-950-TiDP24-C136 - A Trial to Evaluate the Effect of Telaprevir (TVR) on the Results of Electrocardiograms (Electric Recording of the Heart) in Healthy Volunteers Telaprevir; Moxifloxacin; Placebo - Hepatitis C | Phase 1 | Completed | Tibotec BVBA | 44 | 2009-10-01 | 2010-12-17 |
| VX-950-TiDP24-C133 - A Phase I Study Investigating the Interaction Between Telaprevir and Escitalopram Telaprevir; Escitalopram - Hepatitis C | Phase 1 | Completed | Tibotec BVBA | 16 | 2009-09-01 | 2010-12-17 |
| Drug-Drug Interaction Study of VCH-222 and Telaprevir in Healthy Subjects VCH-222, telaprevir - Hepatitis C | Phase 1 | Completed | Vertex Pharmaceuticals Incorporated | 30 | 2009-08-01 | 2010-01-07 |
| A Study to Investigate the Potential Interaction Between Telaprevir and Methadone, at Steady-State Telaprevir, Methadone - Healthy Participants | Phase 1 | Completed | Tibotec BVBA | 18 | 2009-07-01 | 2012-12-03 |
| VX-950-TiDP24-C132: A Study to Investigate the Effect of Renal Impairment on the Pharmacokinetics of Telaprevir. telaprevir - Hepatitis C, Kidney Diseases | Phase 1 | Completed | Tibotec BVBA | 24 | 2009-06-01 | 2010-12-17 |
| VX-950-TiDP24-C134: Drug-drug Interaction Trial Between Combination of Efavirenz and Tenofovir Disoproxil Fumarate and Different Dosages of Telaprevir on Healthy Volunteer Efavirenz; Tenofovir disoproxil fumarate; Telaprevir - Hepatitis C, HCV | Phase 1 | Completed | Tibotec BVBA | 20 | 2009-02-01 | 2010-12-17 |
| VX-950-TiDP24-C124: A Phase I Trial to Investigate the Potential Pharmacokinetic Interactions Between Telaprevir and Darunavir/Ritonavir and Between Telaprevir and Fosamprenavir/Ritonavir at Steady-state. Telaprevir; Darunavir; Ritonavir; Fosamprenavir - Hepatitis C, Telaprevir | Phase 1 | Completed | Tibotec BVBA | 40 | 2008-06-01 | 2010-12-17 |
| A Phase 1 Study of MP-424, Peginterferon Alfa 2b, and Ribavirin in Hepatitis C MP-424(H), PEG-IFN-a-2b, RBV, MP-424 (L), PEG-IFN-a-2b, RBV - Hepatitis C | Phase 1 | Completed | Tanabe Pharma Corporation | 20 | 2008-04-01 | 2026-01-06 |
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Hepatitis C (16) · Hepatitis C, Chronic (4) · Acquired Immunodeficiency Syndrome (2) · HIV Infections (1) · Hemophilia A (1) · Hepatic Insufficiency (1) · Hepatitis (1) · Infections (1) · Kidney Diseases (1) · Liver Diseases (1) · Opioid-Related Disorders (1) · Thrombocytopenia (1)
Tibotec BVBA (6) · Vertex Pharmaceuticals Incorporated (6) · Janssen Infectious Diseases BVBA (2) · Tanabe Pharma Corporation (2) · ViiV Healthcare (2) · GlaxoSmithKline (1) · Kenneth Sherman (1) · Presidio Pharmaceuticals, Inc. (1) · Santaris Pharma A/S (1) · Tibotec Pharmaceuticals, Ireland (1)
United States (9) · Belgium (3) · Germany (3) · Japan (2) · Netherlands (2) · Czechia (1) · Italy (1) · New Zealand (1) · Spain (1) · United Kingdom (1)
Fumitaka Suzuki, MD (2) · Paul Rice, MD (2) · Kenneth E Sherman, MD, PhD (1) · Paul Y Kwo, MD (1) · Scott McCallister, M.D. (1)
PMID 22239508, PMID 23190247, PMID 23478952, PMID 24838177, PMID 25975423, PMID 25975934
R34HL109334 (1)