8 completed, 2 recruiting, 1 no longer available, 1 terminated. 3 Phase 1, 3 Phase 3, 3 Phase 4, 2 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 3 | Completed 2, Recruiting 1 |
| Phase 4 | 3 | Completed 1, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Completed 2 |
| Not applicable | 1 | Terminated 1 |
Follow taurolidine: new trials by email Literature Review of taurolidine trials Research Report on taurolidine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Open-Label Study to Assess Safety and Time to Catheter-related Bloodstream Infections (CRBSI) in Subjects From Birth to < 18 Years of Age (taurolidine and heparin) catheter lock solution, Standard of Care - Catheter-Related Infections | Phase 4 | Recruiting | CorMedix Therapeutics | 36 | 2025-07-08 | 2026-09-25 |
| Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults And Adolescent Participants Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC) (taurolidine and heparin) catheter lock solution, Heparin - Central Line Associated Blood Stream Infections (CLABSI) | Phase 3 | Recruiting | CorMedix Therapeutics | 200 | 2025-05-14 | 2026-09-25 |
| Taurolidine Containing Antimicrobial CIED Wash to Prevent Infection TauroPace, Hydrogen Peroxide, Taurolidine - Cardiac Implantable Electronic Device Infection | Completed | Prof. Dr. Hendrik Bonnemeier | 1417 | 2020-01-01 | 2023-12-06 | |
| Trial to Evaluate Safety, Tolerability, Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis PerioSept(r) - Periodontitis | Phase 2 | Completed | Geistlich Pharma AG | 12 | 2019-08-26 | 2020-10-19 |
| Study Assessing Safety & Effectiveness of a Catheter Lock Solution in Dialysis Patients to Prevent Bloodstream Infection Neutrolin, Heparin - Kidney Failure, Chronic, Catheter-Related Infections | Phase 3 | Completed | CorMedix Therapeutics | 806 | 2015-12-01 | 2025-02-25 |
| A Phase I/II Study to Evaluate the Safety and Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis PerioSept(r) - Periodontitis | Phase 1 / Phase 2 | Completed | Geistlich Pharma AG | 127 | 2015-07-01 | 2019-09-17 |
| Heparin Versus Taurolidine to Bloodstream Infection Prevention Related in Central Venous Catheter in Children Taurolidine, Heparin - Catheter-Related Infections | Phase 4 | Unknown | Hospital de Clinicas de Porto Alegre | 20 | 2014-09-01 | 2015-08-04 |
| Taurolidine Lock in Long Term Parenteral Nutrition 2% Taurolidine Lock, 1.35% Taurolidine - Home Parenteral Nutrition, Central Venous Catheter | Phase 4 | Completed | Stanley Dudrick's Memorial Hospital | 30 | 2012-11-01 | 2013-12-11 |
| Effect of Taurolidin on Prevention of Bloodstream Infection Taurolidine, Physiologic Serum - Sepsis | Not applicable | Terminated | University Hospital, Rouen | 39 | 2007-10-01 | 2013-03-05 |
| The AOT (Acridine Orange and Taurolidine) Trial taurolidine - Parenteral Nutrition, Infection | Phase 3 | Completed | Radboud University Medical Center | 60 | 2006-06-01 | 2009-02-11 |
| Taurolidine in Treating Patients With Recurrent or Progressive Glioma taurolidine - Brain and Central Nervous System Tumors | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 2001-05-01 | 2013-06-18 | |
| Taurolidine in Treating Patients With Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer chemotherapy, taurolidine - Fallopian Tube Cancer, Ovarian Cancer | Phase 1 | Completed | Memorial Sloan Kettering Cancer Center | 2001-03-01 | 2013-06-18 | |
| Expanded Access Program for Patients at Risk for Catheter-related Infections Who Are Not Eligible for DefenCath® Clinical Trials Taurolidine and Heparin - Catheter-related Bloodstream Infection | No longer available | CorMedix Therapeutics | 2026-07-01 |
Catheter-Related Infections (3) · Periodontitis (2) · Sepsis (2) · Astrocytoma (1) · Brain Neoplasms (1) · Carcinoma, Ovarian Epithelial (1) · Central Nervous System Neoplasms (1) · Fallopian Tube Neoplasms (1) · Glioblastoma (1) · Gliosarcoma (1) · Hyperphagia (1) · Infections (1) · Kidney Failure, Chronic (1) · Ovarian Neoplasms (1)
CorMedix Therapeutics (4) · Geistlich Pharma AG (2) · Memorial Sloan Kettering Cancer Center (2) · Hospital de Clinicas de Porto Alegre (1) · Prof. Dr. Hendrik Bonnemeier (1) · Radboud University Medical Center (1) · Stanley Dudrick's Memorial Hospital (1) · University Hospital, Rouen (1)
United States (7) · France (1) · Germany (1) · Netherlands (1) · Poland (1) · Turkey (Türkiye) (1)
Michael McGuire, DDS (2) · Adriano Taniguchi, MD (1) · Antony Pfaffle, MD (1) · Donald Clem, DDS (1) · Elza Mello, PhD (1) · Geert Wanten, MD, PhD (1) · Helena Goldani, PhD (1) · Jeffrey J. Raizer, MD (1) · Maria Carolina Witkowski, MD (1) · Paul Sabbatini, MD (1) · Stanislaw Klek, Assoc Prof (1) · Stefan Borov, MD (1) · Suzi Camey, PhD (1) · Tae-Ju Oh, DDS (1)