16 completed, 2 terminated, 2 unknown, 1 recruiting. 14 Phase 2, 8 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Completed 10, Terminated 2, Recruiting 1, Unknown 1 |
| Phase 1 | 8 | Completed 7, Unknown 1 |
| Phase 3 | 2 | Completed 2 |
Follow Suramin: new trials by email Literature Review of Suramin trials Research Report on Suramin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suramin for the Treatment of Autism Trial: KZ101 in a Male Pediatric Population With Autism Spectrum Disorder (ASD) KZ101, Placebo - Autism Spectrum Disorder (ASD) | Phase 2 | Recruiting | Children's Hospital of Orange County | 45 | 2025-04-09 | 2026-07-30 |
| Study of Suramin in Subjects With Furosemide-Resistant AKI Suramin, Placebo - Acute Kidney Injury | Phase 2 | Unknown | Rediscovery Life Sciences | 68 | 2020-11-13 | 2023-05-03 |
| Double Blind Trial in Children With Autism Spectrum Disorder Suramin Sodium - Autism Spectrum Disorder | Phase 2 | Completed | Paxmedica | 52 | 2019-06-01 | 2023-11-13 |
| Study to Evaluate the Tolerance and Pharmacokinetics of Suramin Sodium suramin sodium, placebo - Hand, Foot and Mouth Disease | Phase 1 | Unknown | First Affiliated Hospital of Zhejiang University | 36 | 2018-12-19 | 2019-01-15 |
| University of California, San Diego (UCSD) Suramin Autism Treatment-1 (SAT1) Trial Suramin, Saline - Autism Spectrum Disorders | Phase 1 / Phase 2 | Completed | University of California, San Diego | 10 | 2015-05-01 | 2019-07-16 |
| Docetaxel +/- Suramin in 2nd Line Advanced Non-Small Cell Lung Cancer Docetaxel, Suramin - Carcinoma, Non Small Cell Lung | Phase 2 | Completed | University of Wisconsin, Madison | 80 | 2012-06-01 | 2020-05-12 |
| Evaluation of Non-cytotoxic Suramin as a Chemosensitizer in Non-small Cell Lung Cancer Suramin Drug:Docetaxel Drug: Carboplatin, Placebo Drug: Docetaxel Drug: Carboplatin - Non-small Cell Lung Cancer | Phase 2 | Terminated | Optimum Therapeutics, LLC | 14 | 2010-08-01 | 2015-05-21 |
| Fluorouracil and Low-Dose Suramin as Chemosensitization in Treating Patients With Metastatic Renal Cell (Kidney) Cancer Fluorouracil, Pharmacological Study, Suramin - Recurrent Renal Cell Carcinoma, Stage IV Renal Cell Cancer | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 36 | 2004-03-01 | 2015-05-25 |
| Suramin and Either Docetaxel or Gemcitabine in Treating Patients With Stage IIIB or Stage IV Platinum-Refractory Non-Small Cell Lung Cancer suramin, docetaxel, gemcitabine hydrochloride - Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-07-01 | 2013-06-04 |
| Suramin and Paclitaxel in Treating Women With Stage IIIB-IV Breast Cancer suramin, paclitaxel, pharmacological study - Recurrent Breast Cancer, Stage IIIB Breast Cancer | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 31 | 2002-12-01 | 2015-03-17 |
| Suramin in Treating Patients With Recurrent Bladder Cancer suramin, conventional surgery - Bladder Cancer | Phase 1 | Completed | Cancer Research UK | 15 | 2000-10-01 | 2013-06-26 |
| Suramin, Paclitaxel, and Carboplatin in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer suramin, carboplatin, paclitaxel - Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 82 | 2000-09-01 | 2013-06-04 |
| Suramin Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme suramin, radiation therapy - Brain and Central Nervous System Tumors | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 54 | 1999-12-01 | 2012-05-03 |
| Combination Chemotherapy With Suramin Plus Doxorubicin in Treating Patients With Advanced Solid Tumors doxorubicin hydrochloride, suramin - Adrenocortical Carcinoma, Breast Cancer | Phase 1 | Completed | Mayo Clinic | 1997-10-01 | 2011-08-03 | |
| S9427, Suramin in Treating Patients With Stage III or Stage IV Adrenocortical Cancer Incurable by Surgery suramin, therapeutic hydrocortisone - Adrenocortical Carcinoma | Phase 2 | Terminated | SWOG Cancer Research Network | 13 | 1997-03-01 | 2012-10-05 |
| Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer flutamide, goserelin acetate, leuprolide acetate - Prostate Cancer | Phase 3 | Completed | Eastern Cooperative Oncology Group | 1996-10-01 | 2010-11-09 | |
| Low, Intermediate, or High Dose Suramin in Treating Patients With Hormone-Refractory Prostate Cancer suramin, Suramin - Prostate Cancer | Phase 3 | Completed | National Cancer Institute (NCI) | 390 | 1996-01-01 | 2013-02-28 |
| Suramin in Treating Patients With Recurrent Primary Brain Tumors chemotherapy, suramin - Brain and Central Nervous System Tumors | Phase 2 | Completed | Emory University | 1995-07-01 | 2013-06-21 | |
| Suramin in Treating Patients With Refractory or Relapsed Multiple Myeloma or Castleman's Disease suramin - Multiple Myeloma and Plasma Cell Neoplasm | Phase 2 | Completed | University of Arkansas | 1995-05-01 | 2013-02-04 | |
| A Phase I Trial Using Suramin to Treat Superficial Transitional Cell Carcinoma of the Bladder suramin - Bladder Neoplasms, Carcinoma, Transitional Cell | Phase 1 | Completed | National Cancer Institute (NCI) | 18 | 1994-03-01 | 2008-03-04 |
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Carcinoma, Non-Small-Cell Lung (4) · Prostatic Neoplasms (4) · Autism Spectrum Disorder (3) · Adrenocortical Carcinoma (2) · Breast Neoplasms (2) · Central Nervous System Neoplasms (2) · Glioblastoma (2) · Gliosarcoma (2) · Urinary Bladder Neoplasms (2) · Acute Kidney Injury (1) · Astrocytoma (1) · Brain Neoplasms (1) · Carcinoma, Renal Cell (1) · Carcinoma, Transitional Cell (1) · Colonic Neoplasms (1)
National Cancer Institute (NCI) (7) · Cancer Research UK (1) · Children's Hospital of Orange County (1) · Eastern Cooperative Oncology Group (1) · Emory University (1) · First Affiliated Hospital of Zhejiang University (1) · Mayo Clinic (1) · Optimum Therapeutics, LLC (1) · Paxmedica (1) · Rediscovery Life Sciences (1) · SWOG Cancer Research Network (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1) · University of Arkansas (1) · University of California, San Diego (1) · University of Wisconsin, Madison (1)
United States (19) · China (1) · South Africa (1) · United Kingdom (1)
George Wilding, MD (2) · Miguel Villalona-Calero (2) · A. O. Sartor, MD (1) · Adrian L. Harris, MD (1) · Alex A. Adjei, MD, PhD (1) · Anne M Traynor, MD (1) · Aram Kim, MD (1) · Charles Shapiro (1) · Daniel P. Petrylak, MD (1) · Eric J. Small, MD (1) · Jeffrey J. Olson, MD (1) · John J. Laterra, MD, PhD (1) · Louis E. Schroder, MD (1) · Nancy A. Dawson, MD (1)
PMID 11289126, PMID 11448906, PMID 12177096, PMID 14769135, PMID 15484217, PMID 15756004, PMID 15928663, PMID 16098367, PMID 37932739
U01CA076576 (3), P30CA006973 (1), P30CA015083 (1), R01CA093871 (1), U01CA062475 (1), U01CA062502 (1), U01CA069912 (1), U10CA031946 (1), U10CA032102 (1)