9 completed, 3 withdrawn, 1 not yet recruiting, 1 recruiting. 12 Not applicable, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 12 | Completed 8, Withdrawn 2, Not yet recruiting 1, Recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Withdrawn 1 |
| Phase 3 | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Monosodium Glutamate on Microbiome-Derived Imidazole Propionate Production in Healthy Volunteers L-histidine, Monosodium glutamate (MSG), Sodium chloride (NaCl) - Healthy Adult | Not applicable | Not yet recruiting | University of Chicago | 18 | 2026-07-15 | 2026-07-14 |
| Increasing Vegetable Intake Using Monosodium Glutamate: A Reduced-Effort Intervention Salt replacement seasoning (50% salt and 50% MSG) mix, Salt replacement seasoning (70% salt and 30% MSG) mix, NaCl (sodium chloride/table salt) - Healthy Nutrition, Culinary Medicine | Not applicable | Completed | Texas Tech University | 148 | 2023-02-10 | 2024-08-01 |
| ALACOVID Study for Vaccinated Subjects 150 mg 5-ALAPhosphate + SFC, Placebo - COVID-19 Respiratory Infection | Not applicable | Completed | Vedic Lifesciences Pvt. Ltd. | 200 | 2022-03-15 | 2022-07-11 |
| Immunization With BCG Vaccine to Prevent Tuberculosis Infection BCG (Tokyo 172) vaccine, Placebo - Tuberculosis Infection | Phase 3 | Terminated | Henry M. Jackson Foundation for the Advancement of Military Medicine | 16 | 2021-12-01 | 2026-01-23 |
| Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC as an Immune System Enhancer Along With Vaccination Against COVID-19 5-ALA-Phosphate + SFC (5-ALA+SFC) - SARS-COV 2, Covid19 | Not applicable | Withdrawn | Royal College of Surgeons in Ireland - Medical University of Bahrain | 2021-08-15 | 2021-09-22 | |
| Pilot Study to Evaluate the Safety, Tolerability, and Efficacy of 5-ALA-Phosphate + SFC in Subjects With COVID-19 5-ALA-Phosphate + SFC (5-ALA + SFC) - SARS-CoV 2, COVID-19 | Not applicable | Completed | Royal College of Surgeons in Ireland - Medical University of Bahrain | 15 | 2020-11-15 | 2022-02-09 |
| A Study to Assess the Safety and Efficacy of 5-aminolevulinic Acid Hydrochloride (5-ALA HCl) and Sodium Ferrous Citrate (SFC) Added on Artemisinin-based Combination Therapy (ACT) in Adult Patients With Uncomplicated Malaria 5-aminolevulinic acid hydrochloride (5-ALA HCl) 600 mg QD, Sodium ferrous citrate (SFC) 472 mg QD, Artemisinin-based combination (ACT) - Malaria | Phase 2 | Withdrawn | Neopharma Japan Co., Ltd. | 2019-09-06 | 2020-03-03 | |
| Impact of Monosodium Glutamate on 68GA-PSMA-11, PET Imaging Biodistribution in Patients With Prostate Cancer Biospecimen Collection, Computed Tomography, Gallium Ga 68-labeled PSMA-11 - Prostate Carcinoma | Early Phase 1 | Completed | Jonsson Comprehensive Cancer Center | 14 | 2019-06-05 | 2020-12-02 |
| Glutamate Supplementation in Young Men MSG, CHO, Placebo A - Healthy | Not applicable | Completed | University of Waterloo | 11 | 2018-03-19 | 2019-06-12 |
| Repeated Exposure to Umami Taste on Taste Perception, Hedonics, and Satiety Supplementation of diet with MSG, No supplementation of diet with MSG - Umami Taste Perception | Not applicable | Completed | Cornell University | 64 | 2016-10-01 | 2022-02-07 |
| Monosodium Glutamate on Gastric Emptying Monosodium glutamate - Delayed Gastric Emptying | Not applicable | Withdrawn | Veronica Beatriz Busoni | 2016-04-01 | 2023-03-02 | |
| Taste Physiology in Obese Volunteers Before and After Bariatric Surgery Placebo, Glucose, Monosodium glutamate - Obesity | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 16 | 2014-12-01 | 2025-04-03 |
| Taste Physiology in Healthy, Normal-weight Volunteers Single intragastric instillation of 200 mL tap water via nasogastric tube, Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube, Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube - Exploratory Behavior | Not applicable | Completed | University Hospital, Basel, Switzerland | 12 | 2013-03-01 | 2014-10-03 |
| Monosodium L-glutamate (MSG) on Satiety Soup with MSG, Control soup no MSG - Nutrition Intervention | Not applicable | Completed | Ajinomoto Co., Inc. | 75 | 2012-06-01 | 2015-05-18 |
| MSG and Gastrointestinal Motility Monosodium glutamate, Sodium chloride - Gastroesophageal Reflux | Not applicable | Completed | Gunma University | 40 | 2009-12-01 | 2015-03-26 |
COVID-19 (2) · Exploratory Behavior (1) · Gastroesophageal Reflux (1) · Gastroparesis (1) · Hypernatremia (1) · Latent Tuberculosis (1) · Malaria (1) · Obesity (1) · Prostatic Neoplasms (1)
Royal College of Surgeons in Ireland - Medical University of Bahrain (2) · University Hospital, Basel, Switzerland (2) · Ajinomoto Co., Inc. (1) · Cornell University (1) · Gunma University (1) · Henry M. Jackson Foundation for the Advancement of Military Medicine (1) · Jonsson Comprehensive Cancer Center (1) · Neopharma Japan Co., Ltd. (1) · Texas Tech University (1) · University of Chicago (1) · University of Waterloo (1) · Vedic Lifesciences Pvt. Ltd. (1) · Veronica Beatriz Busoni (1)
United States (4) · Switzerland (2) · Bahrain (1) · Canada (1) · India (1) · Japan (1) · United Kingdom (1)
Abdulla Darwish, Dr (1) · Abdullah Darwish, Dr (1) · Christoph Beglinger, MD (1) · Christoph Beglinger, Prof (1) · Jeremie Calais, M.D. (1) · Marina Mourtzakis, PhD (1) · Merlin L. Robb, MD (1) · Naomi E. Aronson, MD (1) · Shannon Galyean, PhD (1) · Sonia Pombo, PhD (1) · Veronica B Busoni, MD (1)
PMID 19056566, PMID 21030612, PMID 22978669, PMID 24744869, PMID 29796671, PMID 40535918, PMID 41698328