8 completed, 1 terminated, 1 unknown. 10 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 8, Terminated 1, Unknown 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
Follow Simulect: new trials by email Literature Review of Simulect trials Research Report on Simulect
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant Patients Everolimus, Tacrolimus, Cyclosporin A - Kidney Transplantation, Renal Transplantation | Phase 3 | Completed | Novartis Pharmaceuticals | 612 | 2012-12-27 | 2017-05-01 |
| Thymoglobulin Induction in Kidney Transplant Recipients antithymocyte globulin, Basiliximab - Kidney Transplantation, Ischemia-Reperfusion Injury | Phase 3 | Unknown | University of Oxford | 40 | 2011-01-01 | 2010-11-11 |
| Campath, Calcineurin Inhibitor Reduction and Chronic Allograft Nephropathy Alemtuzumab, Basiliximab, Sirolimus - Kidney Transplantation | Phase 2 / Phase 3 | Completed | University of Oxford | 852 | 2010-09-01 | 2020-04-02 |
| Phase 3b Study to Evaluate Advagraf in Combination With Mycophenolate Mofetil and Basiliximab in Liver Transplantation Advagraf, Mycophenolate Mofetil, Basiliximab - Liver Transplantation | Phase 3 | Completed | Astellas Pharma Inc | 893 | 2009-09-30 | 2024-11-01 |
| Comparison of Standard Versus Low Dose Advagraf® With or Without Angiotensin-converting Enzyme Inhibitor (ACEi)/Angiotensin Receptor Blocker (ARB) on Histology and Function of Renal Allografts tacrolimus, Simulect, Cellcept - Kidney Transplantation | Phase 3 | Completed | Astellas Pharma Inc | 281 | 2009-08-17 | 2024-11-01 |
| Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant basiliximab - End Stage Renal Disease | Phase 2 / Phase 3 | Terminated | Drexel University College of Medicine | 5 | 2009-05-01 | 2015-02-10 |
| CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment anti-CD 25 mAb, Sirolimus, MMF - End Stage Liver Disease, Impaired Renal Function | Phase 3 | Completed | University of Regensburg | 27 | 2008-12-01 | 2014-12-16 |
| Preservation of Renal Function in Liver Transplant Recipients With Certican Therapy everolimus, basiliximab, CNI - Liver Transplantation | Phase 3 | Completed | Novartis Pharmaceuticals | 276 | 2006-08-01 | 2015-02-06 |
| Efficacy and Safety Study of Everolimus Plus Reduced Cyclosporine Versus Mycophenolic Acid Plus Cyclosporine in Kidney Transplant Recipients Everolimus, Mycophenolic Acid (MPA), Cyclosporine A (CsA) - Kidney Transplantation, Graft Rejection | Phase 3 | Completed | Novartis | 833 | 2005-10-01 | 2011-05-10 |
| Everolimus in a Cyclosporine Microemulsion-free Regimen Compared to a Low-dose Cyclosporine Microemulsion Regimen, in de Novo Kidney Transplant Patients Everolimus (Certican), Cyclosporine (Neoral), Steroid - Organ Transplantation, Renal Transplantation | Phase 3 | Completed | Novartis | 114 | 2005-07-01 | 2018-08-09 |
End Stage Liver Disease (1) · Graft vs Host Disease (1) · Kidney Failure, Chronic (1) · Rejection, Psychology (1) · Renal Insufficiency (1) · Reperfusion Injury (1)
Astellas Pharma Inc (2) · Novartis (2) · Novartis Pharmaceuticals (2) · University of Oxford (2) · Drexel University College of Medicine (1) · University of Regensburg (1)
Germany (4) · United Kingdom (3) · Austria (2) · Canada (2) · France (2) · Switzerland (2) · United States (2) · Argentina (1) · Belarus (1) · Belgium (1) · Brazil (1) · Colombia (1) · Czechia (1) · Finland (1) · Hungary (1)
Andreas A Schnitzbauer, MD (1) · Colin Baigent (1) · Hans J Schlitt, MD (1) · Kathryn Wood, DPhil BSc (1) · Marcus N Scherer, MD (1) · Martin J Landray (1) · Mysore Anil S. Kumar, MD (1) · Paul Harden (1) · Peter Friend (1) · Peter J Friend, MD FRCS (1) · Richard Haynes (1)
PMID 20840760, PMID 23230975, PMID 23422495, PMID 23641902, PMID 25078310, PMID 26018348, PMID 26888217, PMID 29226570, PMID 30582281, PMID 38993854, PMID 39082471, PMID 39382091, PMID 39739990
2008 (2), 2005 (1), 2009 (1)