10 recruiting, 5 unknown, 3 completed, 3 not yet recruiting. 13 Phase 2, 7 Phase 3, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Recruiting 6, Unknown 3, Completed 2, Not yet recruiting 2 |
| Phase 3 | 7 | Recruiting 3, Unknown 2, Completed 1, Not yet recruiting 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow SCRT: new trials by email Literature Review of SCRT trials Research Report on SCRT
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Total Neoadjuvant Therapy With Short Course Radiation Therapy in Gastric Cancer Short course radiation therapy, Standard of care neoadjuvant chemotherapy - Gastric Cancer | Phase 2 | Not yet recruiting | Washington University School of Medicine | 20 | 2026-10-31 | 2026-08-06 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| Efficacy and Safety of Retlirafusp Alfa Plus Bevacizumab and Chemotherapy With or Without Short-Course Radiotherapy in Patients With CRCLM SCRT, Retlirafusp alfa Injection, Bevacizumab - CRC (Colorectal Cancer) | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 60 | 2026-07-30 | 2026-09-22 |
| Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old FOLFOX4s, Short Course Radiotherapy - Locally Advanced Rectal Adenocarcinoma | Phase 3 | Not yet recruiting | UNICANCER | 160 | 2026-07-24 | 2026-07-24 |
| SCRT + Chemo Targeted Immuno-neoadjuvant Therapy for High-risk pMMR/MSS RC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 3 | Recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 204 | 2026-05-20 | 2026-07-01 |
| A Clinical Trial Comparing Long-Course Versus Short-Course Radiotherapy Followed by Immunotherapy Combined With Total Neoadjuvant Therapy (TNT) to Long-Course Radiotherapy Followed by TNT in Locally Advanced Rectal Cancer Short-course radiotherapy, Long-course radiotherapy, Capecitabine - Rectal Cancer, Total Neoadjuvant Therapy | Phase 3 | Recruiting | Tao Zhang | 444 | 2026-05-15 | 2026-05-13 |
| SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC SCRT, Liposomal Irinotecan, Oxaliplatin - Rectal Cancer, Adenocarcinoma | Not applicable | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 49 | 2025-11-30 | 2026-03-16 |
| Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC) Long-course radiotherapy, Oxaliplatin, Capecitabine - Locally Advanced Rectal Cancer, Neoadjuvant Therapy | Phase 2 | Recruiting | Fudan University | 138 | 2025-08-28 | 2025-09-02 |
| Phase II RCT of LCRT vs SCRT + CAPOX/PD-1i/COX-2i in MSS Locally Advanced Rectal Cancer LCRT, SCRT, CAPOX - Colorectal Cancer | Phase 2 | Recruiting | Fudan University | 138 | 2025-08-01 | 2025-09-04 |
| SCRT+mFOLFOX6+PD-1 Antibody and Targeted Therapy for High-Risk pMMR/MSS Rectal Cancer Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Completed | Sixth Affiliated Hospital, Sun Yat-sen University | 49 | 2025-04-02 | 2026-08-04 |
| Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer short-course radiotherapy, Ivonescimab, capecitabine - Locally Advanced Rectal Cancer, Neoadjuvant Therapy | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 45 | 2024-10-16 | 2025-01-31 |
| Short-course Radiotherapy Combined With CAPOX and PD-1 Antibody Versus Long-course Chemoradiotherapy Combined With CAPOX for Early Low-lying Rectal Cancer Short-course radiotherapy, PD-1 antibody (Toripalimab), Long-course radiotherapy - Early Low Rectal Cancer | Phase 2 | Recruiting | Fudan University | 134 | 2024-04-01 | 2024-06-17 |
| SCRT Followed by Camrelizumab Combined With Fluzoparib and Chemotherapy as Neoadjuvant Therapy for LARC SCRT, Camrelizumab, Fluzoparib - Colorectal Cancer | Phase 2 | Unknown | Huazhong University of Science and Technology | 33 | 2023-06-28 | 2024-07-24 |
| The First-line Treatment of RCLM With RAS Mutation Was Local Short-course Radiotherapy (SCRT) + PD-1+ Standard Therapy PD-1, SCRT, Bevacizumab - Rectal Cancer | Phase 2 | Unknown | Fujian Cancer Hospital | 30 | 2023-05-01 | 2022-12-07 |
| Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer Cadonilimab Injection, Short-course radiotherapy, Consolidation chemotherapy - Locally Advanced Rectal Carcinoma | Phase 2 | Completed | Shenzhen People's Hospital | 27 | 2023-04-11 | 2025-02-05 |
| TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer SCRT, CAPOX, CAPOXIRI - Locally Advanced Rectal Cancer | Phase 3 | Recruiting | National Cancer Center Hospital East | 608 | 2022-11-21 | 2025-04-03 |
| A Phase III Trial of Anus-preservation in Low Rectal Adenocarcinoma Based on MMR/MSI Status Toripalimab, CRT, SCRT - Toripalimab, Radiation | Phase 3 | Unknown | Zhejiang Cancer Hospital | 174 | 2022-11-01 | 2022-12-30 |
| A Prospective Phase II Study of Individualized Neoadjuvant Chemoradiotherapy for Rectal Cancer Based on Recurrence Risk Concurrent Chemoradiotherapy Radiotherapy, Short-course Radiotherapy, Local dose increase of Short-course Radiotherapy - Rectal Cancer | Phase 2 | Unknown | Jing Jin, M.D. | 150 | 2020-12-01 | 2021-06-08 |
| Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer Epacadostat, Short-course radiation therapy, CAPOX chemotherapy - Rectal Cancer | Phase 1 / Phase 2 | Recruiting | Washington University School of Medicine | 49 | 2020-01-06 | 2026-02-11 |
| Efficacy and Safety of So-Cheong-Ryong-Tang on Perennial Allergic Rhinitis SCRT, Placebos - Perennial Allergic Rhinitis | Phase 3 | Unknown | Kyung Hee University Hospital at Gangdong | 154 | 2016-12-31 | 2017-03-14 |
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Rectal Neoplasms (10) · Colorectal Neoplasms (4) · Adenocarcinoma (1) · Digestive System Neoplasms (1) · Gastrointestinal Neoplasms (1) · Intestinal Neoplasms (1) · Respiratory Tract Infections (1) · Rhinitis, Allergic, Perennial (1) · Stomach Neoplasms (1)
Fudan University (3) · Sixth Affiliated Hospital, Sun Yat-sen University (3) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (3) · Washington University School of Medicine (2) · Fujian Cancer Hospital (1) · Huazhong University of Science and Technology (1) · Jing Jin, M.D. (1) · Korea Health Industry Development Institute (1) · Kyung Hee University Hospital at Gangdong (1) · National Cancer Center Hospital East (1) · Shenzhen People's Hospital (1) · Tao Zhang (1) · UNICANCER (1) · Zhejiang Cancer Hospital (1)
China (14) · United States (2) · Japan (1) · South Korea (1)
Tao Zhang, MD (2) · Zhen Zhang, M.D, PH.D (2) · Guohui Wan, PhD. (1) · Hongli Liu, Professor (1) · Juan Huang, PhD. (1) · Jun Huang, PhD (1) · Jun Huang, PhD. (1) · Kaixiong Tao, MD (1) · Minhee Kim (1) · Moh'd Khusman, M.D. (1) · Patrick Grierson, M.D., Ph.D. (1) · YangChun Park, Ph. D. (1) · Yuan Tang, M.D. (1) · Zhenyu Lin, MD (1)
2025 (1), R01CA278197 (1)