3 terminated, 2 completed, 1 withdrawn. 4 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Terminated 3, Completed 1 |
| Phase 1 | 2 | Completed 1, Withdrawn 1 |
Follow Roscovitine: new trials by email Literature Review of Roscovitine trials Research Report on Roscovitine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease Seliciclib - Cushing Disease | Phase 2 | Completed | Cedars-Sinai Medical Center | 5 | 2018-11-02 | 2026-10-16 |
| Evaluation of (R)-Roscovitine Safety and Effects in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation Roscovitine, Placebo - Cystic Fibrosis | Phase 2 | Terminated | University Hospital, Brest | 49 | 2016-02-22 | 2025-12-12 |
| Treatment of Cushing's Disease With R-roscovitine R-roscovitine - Cushings Disease | Phase 2 | Terminated | Shlomo Melmed, MD | 4 | 2014-05-01 | 2021-11-04 |
| Maximum Tolerated Dose (MTD) of Liposomal Doxorubicin in Combination With Seliciclib for Patients With Metastatic Triple Negative Breast Cancer (TNBC) Liposomal Doxorubicin, Seliciclib - Breast Cancer | Phase 1 | Withdrawn | M.D. Anderson Cancer Center | 2012-09-01 | 2012-06-26 | |
| A Study of Oral Sapacitabine and Oral Seliciclib in Patients With Advanced Solid Tumors sapacitabine and seliciclib - Advanced Solid Tumors | Phase 1 | Completed | Cyclacel Pharmaceuticals, Inc. | 103 | 2009-04-01 | 2021-12-22 |
| Efficacy Study of Oral Seliciclib to Treat Non-Small Cell Lung Cancer seliciclib, placebo - Non-small Cell Lung Cancer | Phase 2 | Terminated | Cyclacel Pharmaceuticals, Inc. | 187 | 2006-08-09 | 2021-12-22 |
Adrenocortical Hyperfunction (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Cystic Fibrosis (1) · Neoplasm Metastasis (1) · Pituitary ACTH Hypersecretion (1) · Triple Negative Breast Neoplasms (1)
Cyclacel Pharmaceuticals, Inc. (2) · Cedars-Sinai Medical Center (1) · M.D. Anderson Cancer Center (1) · Shlomo Melmed, MD (1) · University Hospital, Brest (1)
United States (4) · France (1)
Ning-Ai Liu, MD, PhD (2) · Shlomo Melmed, MD (2) · Chandra Belani, M.D. (1) · Geoffrey Shapiro, M.D. (1) · Sara Tolaney, M.D. (1) · Stacy Moulder, MD (1)
R01CA152228 (1), R21DK103198 (1)