5 completed, 3 unknown, 2 not yet recruiting, 2 withdrawn. 8 Phase 2, 5 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 3, Withdrawn 2, Not yet recruiting 1, Terminated 1, Unknown 1 |
| Phase 1 | 5 | Completed 2, Withdrawn 2, Not yet recruiting 1 |
| Not applicable | 1 | Unknown 1 |
Follow this drug Literature Review of Receptors, Interleukin-6 trials Research Report on Receptors, Interleukin-6
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adding Anakinra and Tocilizumab to Nivolumab and Ipilimumab for the Treatment of Melanoma Patients 50 Years of Age or Older Anakinra, Biospecimen Collection, Computed Tomography - Melanoma | Phase 1 | Not yet recruiting | University of Southern California | 40 | 2026-11-01 | 2026-09-24 |
| Anakinra for the Treatment of Postprandial Hypoglycemia in a Patient With Total Gastrectomy and End-Stage Renal Disease Anakinra (interleukin-1 receptor antagonist), Placebo Comparator (0.9% NaCl) - Postprandial Hypoglycemia, End-stage Renal Disease (ESRD) | Phase 2 | Not yet recruiting | Marc Donath | 1 | 2026-07-01 | 2026-05-12 |
| Anakinra for the Prevention of Cytokine Release Syndrome and Neurotoxicity in Patients With B-Cell Non-Hodgkin Lymphoma Receiving CD19-Targeted CAR-T Cell Therapy Anakinra, X-Ray Imaging, Positron Emission Tomography - B-Cell Non-Hodgkin Lymphoma | Phase 2 | Completed | Fred Hutchinson Cancer Center | 27 | 2021-12-27 | 2025-10-23 |
| Late Phase Administration Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation Anakinra, Anakinra Matching Placebo, Dermatophagoides Farinae - Asthma | Phase 1 / Phase 2 | Withdrawn | University of North Carolina, Chapel Hill | 2020-09-01 | 2021-05-14 | |
| Anakinra for the Reduction of CAR-T Toxicity in Patients With Relapsed or Refractory Large B-cell Lymphoma Anakinra, Axicabtagene Ciloleucel, Cyclophosphamide - Hematopoietic and Lymphoid Cell Neoplasm, Recurrent Diffuse Large B-Cell Lymphoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 22 | 2020-07-27 | 2025-01-28 |
| Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome Angiotensin II, Interleukin-1 receptor antagonist - COVID, Acute Respiratory Distress Syndrome | Unknown | Guy's and St Thomas' NHS Foundation Trust | 50 | 2020-06-01 | 2021-08-04 | |
| Anakinra in Preventing Severe Chimeric Antigen Receptor T-Cell Related Encephalopathy Syndrome in Patients With Recurrent or Refractory Large B-cell Lymphoma Anakinra, Axicabtagene Ciloleucel, Cyclophosphamide - Diffuse Large B-Cell Lymphoma, Not Otherwise Specified, High Grade B-Cell Lymphoma | Phase 2 | Terminated | Jonsson Comprehensive Cancer Center | 23 | 2020-03-04 | 2026-02-27 |
| Early Phase Administration of Anakinra as a Rescue Treatment for Inhaled Allergen Challenge-Induced Airway Inflammation Anakinra, Anakinra Matching Placebo, Dermatophagoides Farinae - Asthma | Phase 1 / Phase 2 | Withdrawn | University of North Carolina, Chapel Hill | 2019-08-09 | 2021-05-07 | |
| Lenalidomide and Dexamethasone With or Without Anakinra in Treating Patients With Early Stage Multiple Myeloma Anakinra, Dexamethasone, Laboratory Biomarker Analysis - Indolent Plasma Cell Myeloma, Plasma Cell Myeloma | Phase 1 | Completed | Mayo Clinic | 14 | 2016-04-01 | 2020-03-25 |
| Everolimus and Anakinra or Denosumab in Treating Participants With Relapsed or Refractory Advanced Cancers Anakinra, Denosumab, Everolimus - Advanced Malignant Neoplasm, Metastatic Malignant Neoplasm | Phase 1 | Completed | M.D. Anderson Cancer Center | 57 | 2012-06-19 | 2021-02-25 |
| Effect of Anakinra on Insulin Sensitivity in Type 1 Diabetes Mellitus kineret - Diabetes Mellitus | Phase 2 | Unknown | Radboud University Medical Center | 16 | 2011-04-01 | 2011-04-14 |
| The Effect of Anakinra on Insulin Secretion Anakinra - Glucose Intolerance, Impaired Insulin Secretion | Not applicable | Unknown | Radboud University Medical Center | 16 | 2011-01-01 | 2012-03-26 |
| Treatment of Refractory Adult-onset Still's Disease With Anakinra: a Randomized Study anakinra, comparators - Adult-Onset Still's Disease | Phase 2 | Completed | University of Helsinki | 23 | 2005-12-01 | 2017-03-06 |
Asthma (2) · Inflammation (2) · Lymphoma, Large B-Cell, Diffuse (2) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Disease Progression (1) · Glucose Intolerance (1) · Glucose Metabolism Disorders (1) · Hematologic Neoplasms (1) · Hypoglycemia (1) · Insulin Resistance (1) · Kidney Failure, Chronic (1) · Lymphoma, B-Cell (1) · Melanoma (1) · Multiple Myeloma (1)
M.D. Anderson Cancer Center (2) · Radboud University Medical Center (2) · University of North Carolina, Chapel Hill (2) · Fred Hutchinson Cancer Center (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Jonsson Comprehensive Cancer Center (1) · Marc Donath (1) · Mayo Clinic (1) · University of Helsinki (1) · University of Southern California (1)
United States (6) · Netherlands (2) · Sweden (1) · Switzerland (1) · United Kingdom (1)
Michelle Hernandez, MD (2) · C.J. Tack, MD, PhD, Prof. of Diabetology (1) · Cees J Tack, MD PhD (1) · Dan C Nordstrom, MD, PhD (1) · Filip Janku (1) · Fumito Ito (1) · John Lust (1) · John M Timmerman, MD (1) · Jordan Gauthier (1) · Marlies Ostermann (1) · Matthias Hepprich, PD Dr. med. (1) · Paolo Strati (1)
R01HL135235 (2), 2005 (1), 2025 (1), P30CA014089 (1), P30CA015083 (1)