14 completed, 4 terminated, 1 withdrawn. 19 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 19 | Completed 14, Terminated 4, Withdrawn 1 |
| Phase 2 | 3 | Completed 1, Terminated 1, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Rasagiline in Prodromal Parkinson's Disease Rasagiline - REM Sleep Behavior Disorder, Parkinson Disease | Phase 2 / Phase 3 | Withdrawn | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2023-01-01 | 2025-01-07 | |
| A Phase 3 Study With P2B001 in Subjects With Early Parkinson's P2B001 0.6/0.75 mg, Rasagiline 0.75 mg, Pramipexole 0.6 mg - Parkinson Disease, Early Parkinson's Disease | Phase 3 | Completed | Pharma Two B Ltd. | 544 | 2018-01-19 | 2023-03-21 |
| Safety, Tolerability and Efficacy of Two Doses of Once Daily P2B001 in Subjects With Early Parkinson's Disease P2B001 once daily (pramipexole 0.6 mg / rasagiline 0.75 mg),, Placebo, P2B001 once daily (pramipexole 0.3 mg / rasagiline 0.75 mg), - Parkinson's Disease | Phase 2 / Phase 3 | Completed | Pharma Two B Ltd. | 149 | 2013-12-01 | 2023-04-07 |
| Rasagiline in Early Parkinson's Disease Patients Not Treated With Levodopa in China rasagiline, placebo - Parkinson's Disease | Phase 3 | Completed | H. Lundbeck A/S | 130 | 2012-04-01 | 2014-12-23 |
| Azilect® (Rasagiline) in Levodopa-treated Parkinson's Patients With Motor Fluctuations in China Placebo, Azilect® - Parkinson's Disease | Phase 3 | Completed | H. Lundbeck A/S | 321 | 2011-12-01 | 2018-09-10 |
| Clinical Trial of Rasagiline in Levodopa-Treated Parkinson's Disease Patients With Motor Fluctuations Rasagiline, Placebo - Parkinson´s Disease | Phase 3 | Completed | Chongqing Fortune Pharmaceutical Co., Ltd. | 268 | 2011-11-01 | 2013-09-13 |
| Study of Azilect® (Rasagiline) in Levodopa-treated Parkinson's Disease Patients With Motor Fluctuations in Korea Placebo, Azilect® - Parkinson's Disease | Phase 3 | Completed | H. Lundbeck A/S | 132 | 2011-01-01 | 2013-12-03 |
| An Active-Controlled Extension Study to NCT01155466 [P04938] and NCT01227265 [P07037] (P06153) Preladenant, Rasagiline, Placebo to preladenant - Parkinson Disease, Idiopathic Parkinson Disease | Phase 3 | Terminated | Merck Sharp & Dohme LLC | 839 | 2010-11-18 | 2018-11-06 |
| Safety and Efficacy of Rasagiline in Restless Legs Syndrome rasagiline, placebo (sugar pill) - Restless Legs Syndrome | Phase 2 / Phase 3 | Terminated | University of Virginia | 52 | 2010-09-01 | 2013-02-11 |
| A Placebo- and Active Controlled Study of Preladenant in Subjects With Moderate to Severe Parkinson's Disease (P04938) Preladenant 2 mg tablet, Preladenant 5 mg tablet, Preladenant 10 mg tablet - Parkinson Disease | Phase 3 | Completed | Merck Sharp & Dohme LLC | 778 | 2010-07-14 | 2018-11-06 |
| A Placebo- and Active-Controlled Study of Preladenant in Early Parkinson's Disease (PD) (P05664) Preladenant 2 mg tablet, Preladenant 5 mg tablet, Preladenant 10 mg tablet - Parkinson Disease | Phase 3 | Terminated | Merck Sharp & Dohme LLC | 1022 | 2010-07-06 | 2018-11-07 |
| Efficacy, Tolerability and Safety of Azilect in Subjects With Progressive Supranuclear Palsy Rasagiline, Sugar pill - Progressive Supranuclear Palsy | Phase 3 | Terminated | Prof. Dr. Stefan Lorenzl | 44 | 2010-01-01 | 2013-04-24 |
| A Randomized Placebo Controlled Study to Show That Rasagiline May Slow Disease Progression for Parkinson's Disease Rasagiline Mesylate, Placebo - Parkinson's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 1174 | 2005-11-01 | 2012-01-12 |
| Safety, Tolerability, and Effectiveness of Rasagiline Mesylate in Patients With Parkinson's Disease rasagiline mesylate - Parkinson's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 306 | 2004-06-01 | 2011-04-12 |
| Study to Evaluate the Safety and Tolerability of Rasagiline in Advanced Parkinson's Disease Patients rasagiline mesylate - Parkinson's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 254 | 2002-05-01 | 2010-03-09 |
| Rasagiline in Advanced Parkinson's Disease Patients With Motor Fluctuations Treated With Levodopa/Carbidopa Therapy. rasagiline mesylate, rasagiline mesylate 1.0 mg - Parkinson's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 254 | 2001-10-01 | 2010-03-09 |
| A Study to Evaluate the Effects of Tyramine in Patients Who Completed the PRESTO Study. rasagiline mesylate, tyramine - Parkinson's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 55 | 2000-10-01 | 2011-04-12 |
| Multicenter Study of Rasagiline in Parkinson's Disease Patients Using Levodopa and Experiencing Motor Fluctuations rasagiline mesylate, 1.0 mg rasagiline mesylate, Placebo - Parkinson's Disease | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 472 | 2000-05-01 | 2010-03-09 |
| Effectiveness, Tolerability and Safety of Rasagiline in Early Parkinson's Disease Patients Not Treated With Levodopa Rasagiline Mesylate, placebo - Parkinson's Disease | Phase 3 | Completed | Teva Neuroscience, Inc. | 404 | 1997-07-01 | 2011-04-12 |
Parkinson Disease (17) · REM Sleep Behavior Disorder (1) · Restless Legs Syndrome (1) · Supranuclear Palsy, Progressive (1) · Synucleinopathies (1)
Teva Branded Pharmaceutical Products R&D, Inc. (6) · H. Lundbeck A/S (3) · Merck Sharp & Dohme LLC (3) · Pharma Two B Ltd. (2) · Chongqing Fortune Pharmaceutical Co., Ltd. (1) · Prof. Dr. Stefan Lorenzl (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Teva Neuroscience, Inc. (1) · University of Virginia (1)
United States (6) · China (3) · Canada (2) · Germany (2) · Israel (1) · Spain (1)
Phyllis Salzman, Ph.D. (4) · Baorong Zhang, MD (1) · Bernad Ravina, MD. MSCE (1) · Gang Zhao (1) · Ira Shoulson, MD (1) · Pninit Litman (1) · Sheila Oren, MD (1) · Stefan Lorenzl, PD Dr. (1) · Tiffini S Voss, MD (1) · Yoni Weiss, MD (1)
PMID 19776408, PMID 21482191, PMID 25420207, PMID 26523919, PMID 27190009, PMID 28490648, PMID 29988514, PMID 30534374, PMID 42414790
2009 (3), 2008 (1)