13 terminated. 13 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 13 | Terminated 13 |
| Phase 2 | 5 | Terminated 5 |
Follow Rapamycin: new trials by email Literature Review of Rapamycin trials Research Report on Rapamycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Siplizumab for Sickle Cell Disease Transplant Siplizumab, Exchange Transfusion, Total Body Irradiation - Anemia, Sickle Cell | Phase 1 / Phase 2 | Terminated | Columbia University | 1 | 2023-09-28 | 2026-06-10 |
| Sirolimus and Durvalumab for the Treatment of Stage I-IIIA Non-small Cell Lung Cancer Durvalumab, Sirolimus - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 1 | Terminated | Emory University | 3 | 2021-01-22 | 2024-08-22 |
| Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial Abemaciclib, Abiraterone, Afatinib - Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Anatomic Stage IV Breast Cancer AJCC v8 | Phase 1 | Terminated | OHSU Knight Cancer Institute | 2 | 2020-04-01 | 2024-03-04 |
| Topical Rapamycin/Sirolimus for Complicated Vascular Anomalies and Other Susceptible Lesions Topical Sirolimus - Vascular Anomaly | Phase 1 | Terminated | Nemours Children's Clinic | 5 | 2020-04-01 | 2025-12-31 |
| Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer Carboplatin, Docetaxel, Laboratory Biomarker Analysis - Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma | Phase 1 / Phase 2 | Terminated | University of Washington | 28 | 2016-02-29 | 2021-10-01 |
| Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT Allogeneic Hematopoietic Stem Cell Transplantation, Laboratory Biomarker Analysis, Mycophenolate Mofetil - Adult Hodgkin Lymphoma, Adult Myelodysplastic Syndrome | Phase 1 | Terminated | Stanford University | 1 | 2016-02-01 | 2018-09-12 |
| Haploidentical Transplant for People With Chronic Granulomatous Disease Using Post Transplant Cyclophosphamide Sirolimus, Donor peripheral blood stem cells., Cyclophosphamide post transplant - Chronic Granulomatous Disease | Phase 1 / Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 7 | 2014-10-23 | 2020-05-12 |
| Rapamycin for Prevention of Chronic Graft-Versus-Host Disease Rapamycin, Tacrolimus - Graft Versus Host Disease | Phase 1 / Phase 2 | Terminated | Yale University | 2 | 2008-02-01 | 2017-02-03 |
| Anti-Third Party T Lymphocytes With Nonmyeloablative Stem Cell Transplantation for Indolent Lymphoid Malignancies Rituximab, Cyclophosphamide, Fludarabine - Leukemia, Lymphoma | Phase 1 | Terminated | M.D. Anderson Cancer Center | 4 | 2007-05-01 | 2011-12-19 |
| Rapamycin in With High-Dose Etoposide and Cytarabine in Relapsed/Refractory Aggressive Lymphoid Malignancies Rapamycin, High dose etoposide and cytarabine (HiVAC) - ALL, Burkitt's Lymphoma | Phase 1 / Phase 2 | Terminated | Abramson Cancer Center at Penn Medicine | 4 | 2007-01-01 | 2025-11-05 |
| A Study of the mTOR Inhibitor Rapamycin (Rapamune, Sirolimus) in Combination With Abraxane in Advanced Solid Cancers Rapamune, Abraxane - Advanced Solid Cancers | Phase 1 | Terminated | Yale University | 23 | 2006-02-01 | 2014-01-14 |
| Study of Combination of Sirolimus and Sutent in Patients With Advanced Solid Tumors Non-Curable With Standard Therapy Sunitinib malate, Rapamycin - Tumors | Phase 1 | Terminated | Yale University | 18 | 2006-02-01 | 2013-12-18 |
| Sirolimus in Treating Young Patients With Relapsed or Refractory Acute Leukemia or Non-Hodgkin's Lymphoma sirolimus - Leukemia, Lymphoma | Phase 1 | Terminated | Children's Hospital of Philadelphia | 10 | 2003-01-01 | 2015-03-12 |
Precursor Cell Lymphoblastic Leukemia-Lymphoma (4) · Blast Crisis (2) · Burkitt Lymphoma (2) · Graft vs Host Disease (2) · Hodgkin Disease (2) · Leukemia (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (2) · Leukemia, Myeloid, Acute (2) · Leukemia, Myeloid, Chronic-Phase (2) · Lymphoma (2) · Lymphoma, Non-Hodgkin (2) · Neoplasm Metastasis (2) · Primary Myelofibrosis (2) · Prostatic Neoplasms (2)
Yale University (3) · Abramson Cancer Center at Penn Medicine (1) · Children's Hospital of Philadelphia (1) · Columbia University (1) · Emory University (1) · M.D. Anderson Cancer Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Nemours Children's Clinic (1) · OHSU Knight Cancer Institute (1) · Stanford University (1) · University of Washington (1)
United States (13)
Craig Johnson, DO (1) · Elizabeth M Kang, M.D. (1) · Jennifer W Carlisle, MD (1) · Lara Davis, MD (1) · Mario Sznol, M.D. (1) · Markus Y Mapara, MD, PhD (1) · Maysa Abu-Khalaf, M.D. (1) · Rajni Agarwal-Hashmi (1) · Richard E. Champlin, MD (1) · Robert Montgomery (1) · Selina Luger, MD (1) · Stuart Seropian, M.D. (1) · Susan Rheingold, MD (1)
P30CA015704 (1), P30CA138292 (1), P50CA097186 (1), P50CA217691 (1)