11 recruiting, 9 completed, 4 terminated, 4 unknown. 16 Phase 2, 10 Phase 1, 5 Phase 3, 4 Early Phase 1, 3 Phase 4.
Follow Propranolol Hydrochloride: new trials by email Literature Review of Propranolol Hydrochloride trials Research Report on Propranolol Hydrochloride
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Propranolol Hydrochloride Combined With Toripalimab and Platinum-based Chemotherapy in Resectable Non-Small Cell Lung Cancer Propranolol Hydrochloride, Toripalimab, Chemotherapy - Resectable Non-Small-Cell Lung Cancer | Phase 1 | Recruiting | Second Xiangya Hospital of Central South University | 9 | 2026-06-01 | 2026-10-21 |
| Propranolol Hydrochloride Combined With Adebrelimab and Platinum-Based Chemotherapy in Small Cell Lung Cancer Propranolol Hydrochloride, Adebrelimab, Chemotherapy - Small Cell Lung Cancer (SCLC) | Phase 1 | Recruiting | Second Xiangya Hospital of Central South University | 18 | 2026-05-29 | 2026-10-21 |
| Propranolol With Tislelizumab Plus GC in Neoadjuvant Bladder UC propranolol, Tislelizumab, gemcitabine - Bladder Urothelial Carcinoma, Lymph Node Metastasis | Phase 1 | Enrolling by invitation | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 12 | 2026-01-01 | 2026-04-22 |
| Propranolol Treatment for Postoperative Chylothorax Propranolol Hydrochloride, Placebo - Postoperative Chylothorax, Congenital Heart Disease | Phase 1 / Phase 2 | Suspended | June Wu | 50 | 2025-09-09 | 2026-05-15 |
| Propranolol for the Treatment of Kaposi Sarcoma in Adults Propranolol Hydrochloride - Kaposi Sarcoma | Phase 2 | Recruiting | Washington University School of Medicine | 25 | 2025-08-20 | 2026-04-06 |
| Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms Propranolol Hydrochloride, Phentolamine Injection - Menopause | Early Phase 1 | Recruiting | University of Missouri-Columbia | 75 | 2025-07-10 | 2025-09-15 |
| Chemotherapy Combined With Propranolol Hydrochloride as Neoadjuvant Therapy for Advanced High-grade Serous Ovarian Cancer Propranolol Hydrochloride, Paclitaxel liposome, Carboplatin - Ovarian Cancer | Phase 2 | Recruiting | Bai-Rong Xia | 136 | 2025-06-20 | 2026-06-30 |
| Propranolol Hydrochloride in Combination With Sintilimab and Platinum-based Chemotherapy for Treatment of Advanced Non-small Cell Lung Cancer Propranolol hydrochloride, Sintilimab, Chemotherapy - Non Small Cell Lung Cancer, Propranolol | Phase 1 | Recruiting | Second Xiangya Hospital of Central South University | 6 | 2024-11-13 | 2024-11-19 |
| Beta-Blocker Influences on Inflammatory and Neural Responses to Stress Propranolol, Placebo - Cardiovascular Disease | Phase 4 | Recruiting | University of North Carolina, Chapel Hill | 120 | 2024-05-01 | 2025-10-29 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Sex Disparities in Hypoxic Vasodilation and Impact of Obesity Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate - Obesity, Vasodilation | Early Phase 1 | Recruiting | University of Missouri-Columbia | 72 | 2023-03-14 | 2026-07-28 |
| Propranolol in Combination With Pembrolizumab and Standard Chemotherapy for the Treatment of Unresectable Locally Advanced or Metastatic Esophageal or Gastroesophageal Junction Adenocarcinoma Biopsy, Biospecimen Collection, Computed Tomography - Clinical Stage II Esophageal Adenocarcinoma AJCC v8, Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Phase 2 | Recruiting | Roswell Park Cancer Institute | 40 | 2023-03-07 | 2025-12-16 |
| PROpranolol for Cerebral Hemorrhage-ASsociated pnEumonia (PRO-CHASE) Propranolol Hydrochloride, control group - Stroke, Vascular Accident | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 168 | 2023-02-21 | 2025-07-14 |
| Beta-blocker Administration for Cardiomyocyte Division N-thymidine, Urine Collection, Echocardiogram - Tetralogy of Fallot, Double Outlet Right Ventricle | Phase 1 | Recruiting | Weill Medical College of Cornell University | 40 | 2022-12-16 | 2025-11-18 |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| Reconsolidation Therapy With Propranolol as a Treatment for Chronic Pain Propranolol Hydrochloride, Placebo, Reactivation procedure - Chronic Low-back Pain, Fibromyalgia | Phase 2 | Completed | Université de Sherbrooke | 48 | 2022-02-07 | 2025-09-26 |
| Propranolol for Protracted Labor Propranolol - Labour;Obstructed, Labor Dystocia | Phase 1 | Completed | Christiana Care Health Services | 80 | 2021-07-27 | 2022-07-28 |
| Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma Pembrolizumab, Propranolol Hydrochloride, Nivolumab - Locally Advanced Bladder Urothelial Carcinoma, Locally Advanced Renal Pelvis Urothelial Carcinoma | Phase 2 | Active not recruiting | Emory University | 6 | 2021-05-20 | 2026-02-19 |
| Propranolol as an Anxiolytic to Reduce the Use of Sedatives From Critically-ill Adults Receiving Mechanical Ventilation Propranolol Hydrochloride - Mechanical Ventilation, Sedation | Phase 3 | Completed | Ottawa Hospital Research Institute | 72 | 2021-01-08 | 2022-12-05 |
| Propranolol Adjuvant Treatment of Bladder Cancer Propranolol Hydrochloride, BCG - Bladder Cancer | Phase 2 | Unknown | Central South University | 242 | 2020-09-06 | 2020-07-30 |
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Aneurysm (3) · Melanoma (3) · Stress Disorders, Post-Traumatic (3) · Carcinoma, Non-Small-Cell Lung (2) · Urinary Bladder Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Adjustment Disorders (1) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Transitional Cell (1) · Cardiovascular Diseases (1) · Cerebral Hemorrhage (1) · Chronic Pain (1)
Second Xiangya Hospital of Central South University (3) · Emory University (2) · Roswell Park Cancer Institute (2) · University of Alberta (2) · University of California, San Francisco (2) · University of Missouri-Columbia (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ain Shams University (1) · Bai-Rong Xia (1) · Beijing Tiantan Hospital (1) · Central South University (1) · Christiana Care Health Services (1) · Douglas Mental Health University Institute (1) · June Wu (1) · Lisa Levine (1)
United States (16) · China (7) · Canada (6) · Netherlands (1) · Switzerland (1)
Sean van Diepen, MD, MSc (2) · Alain Brunet, PhD. (1) · Ashok Hemal (1) · Bai-Rong Xia, Doctor (1) · Bernhard Kuhn, MD (1) · Craig D Steinback, PhD (1) · Craig Steinback, PhD (1) · Guillaume Leonard, PhD (1) · Helen B Gomez, MD (1) · Jacqueline Brown, MD (1) · Jacqueline Limberg, Ph.D. (1) · Jaime Hatcher-Martin, MD, PhD (1) · James Downar, MDCM (1) · June Wu, MD (1)
PMID 26607848, PMID 34265312, PMID 37290102, PMID 38767196, PMID 39982178, PMID 42431386
P30CA012197 (1), P30CA016672 (1), P30CA138292 (1), R01HL155597 (1), R01HL157422 (1)