12 completed, 2 unknown. 7 Phase 4, 3 Phase 3, 2 Early Phase 1, 2 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 5, Unknown 2 |
| Phase 3 | 3 | Completed 3 |
| Early Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 2 |
| Phase 1 | 1 | Completed 1 |
Follow PPV23: new trials by email Literature Review of PPV23 trials Research Report on PPV23
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trials of Adsorbed Cell-free DPT Vaccine (Five-component) Tetanus, Reduced Diphtheria and Acellular Pertussis (Five Components) Combined Vaccine, Adsorbed (Tdcp)), 23-valent Pneumococcal Polysaccharide Vaccine (PPV23), Tdcp - Diphtheria, Tetanus | Phase 2 / Phase 3 | Completed | CanSino Biologics Inc. | 1820 | 2024-12-20 | 2026-08-26 |
| PhaseⅠClinical Trial of 24-valent Pneumococcal Polysaccharide Conjugate Vaccine low dose PCV24, high dose PCV24, PPV23 - Streptococcus Pneumoniae Pneumonia | Early Phase 1 | Completed | Jiangsu Province Centers for Disease Control and Prevention | 240 | 2023-11-18 | 2025-06-18 |
| Clinical Trial of Recombinant Pneumococcal Protein Vaccine PBPV, PPV23 - Pneumonia, Respiratory Tract Diseases | Phase 1 | Completed | CanSino Biologics Inc. | 60 | 2023-03-11 | 2024-12-04 |
| PREVENTING PNEUMOcoccal Disease Through Vaccination (Study 2) PPV23, PCV13, Saline for injection - Streptococcus Pneumonia | Phase 4 | Unknown | Liverpool School of Tropical Medicine | 516 | 2021-07-28 | 2023-01-05 |
| Evaluation of Safety and Immunogenicity of Combined Immunization of PPV23 and IIV4 IIV4 and PPV23, IIV4, PPV23 - Influenza, Human, Pneumonia, Pneumococcal | Phase 4 | Completed | China National Biotec Group Company Limited | 1224 | 2020-09-11 | 2022-08-02 |
| A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Adults at Increased Risk for Pneumococcal Disease (V114-017/PNEU-DAY) V114, Prevnar 13™, PNEUMOVAX™23 - Pneumococcal Infections | Phase 3 | Completed | Merck Sharp & Dohme LLC | 1515 | 2018-07-16 | 2021-01-15 |
| A Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 Followed by PNEUMOVAX™23 in Healthy Adults 50 Years of Age or Older (V114-016/PNEU-PATH) V114, Prevnar 13™, PNEUMOVAX™23 - Pneumococcal Infections | Phase 3 | Completed | Merck Sharp & Dohme LLC | 652 | 2018-06-22 | 2021-11-02 |
| Innovative Anti-pneumococcal Vaccine Strategies in Patients With ANCA-associated Vasculitis Receiving Rituximab Therapy PCV13, PPV23, Rituximab - Invasive Pneumococcal Infection | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 96 | 2018-02-05 | 2025-11-20 |
| Sequential Versus Simultaneous Pneumococcal Vaccination in Elderly: Immunological Memory and Antibody Levels PCV13, PPV23 - Pneumococcal Infections | Phase 4 | Completed | Jena University Hospital | 123 | 2017-10-18 | 2023-12-01 |
| Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine - Rheumatoid Arthritis, Systemic Lupus | Phase 4 | Completed | Region Skane | 300 | 2016-06-14 | 2023-03-29 |
| Immunological Memory Induced by the 13valent Pneumococcal Conjugate(PCV13) and 23valent Plain Polysaccharide Vaccine(PPV23) in HIV-infected Patients PCV13, PPV23 - HIV Infection | Phase 4 | Unknown | Aghia Sophia Children's Hospital of Athens | 40 | 2015-12-01 | 2017-02-02 |
| Vaccinating Children After Chemotherapy Prevnar®13, Pneumovax® 23, Pediacel® - Acute Lymphoblastic Leukemia | Phase 4 | Completed | Canadian Immunization Research Network | 156 | 2015-11-16 | 2022-06-24 |
| Clinical and Immunological Efficiency of Bacterial Vaccines at Adult Patients With Bronchopulmonary Pathology Prevenar-13, Pneumo-23 - Chronic Obstructive Pulmonary Disease, Asthma | Phase 4 | Completed | Mikhael Petrovich Kostinov | 219 | 2012-09-06 | 2020-02-25 |
| Immune Response to Pneumococcal Vaccination in HIV Infected Individuals PPV23 - Pneumococcal Infection | Early Phase 1 | Completed | University of Toledo Health Science Campus | 124 | 2010-07-01 | 2015-08-07 |
Pneumococcal Infections (6) · Pneumonia (3) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (1) · Arthritis, Rheumatoid (1) · Asthma (1) · Diphtheria (1) · HIV Infections (1) · Influenza, Human (1) · Pneumonia, Pneumococcal (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Pulmonary Disease, Chronic Obstructive (1) · Respiratory Tract Diseases (1) · Respiratory Tract Infections (1) · Sjogren's Syndrome (1) · Spondylarthritis (1)
CanSino Biologics Inc. (2) · Merck Sharp & Dohme LLC (2) · Aghia Sophia Children's Hospital of Athens (1) · Assistance Publique - Hôpitaux de Paris (1) · Canadian Immunization Research Network (1) · China National Biotec Group Company Limited (1) · Jena University Hospital (1) · Jiangsu Province Centers for Disease Control and Prevention (1) · Liverpool School of Tropical Medicine (1) · Mikhael Petrovich Kostinov (1) · Region Skane (1) · University of Toledo Health Science Campus (1)
China (4) · United States (3) · Canada (2) · Russia (2) · Australia (1) · Chile (1) · France (1) · Germany (1) · New Zealand (1) · Poland (1) · South Korea (1) · Spain (1) · Taiwan (1) · United Kingdom (1)
Aleksander V Zhestkov, Professor (1) · Andrei D Protasov, Professor (1) · Hanqing He (1) · Jehns Martineus, MD (1) · Julie MA Westerink, MD (1) · Karina Top, MD, MS (1) · Mathias Pletz, MD, PhD (1) · Mikhael P Kostinov, Professor (1) · Shanying Zhang (1) · Vana Spoulou (1)
PMID 10762563, PMID 11115712, PMID 1347058, PMID 2025948, PMID 2572650, PMID 26930208, PMID 27239929, PMID 29488477, PMID 2966810, PMID 29722823, PMID 3183430, PMID 32067048, PMID 32087733, PMID 34489128, PMID 35146039, PMID 3572201, PMID 35798520, PMID 3652522, PMID 40537903, PMID 41698388, PMID 42743942, PMID 7690497, PMID 8207642, PMID 8244356, PMID 8580899, PMID 9037057, PMID 9186784, PMID 9186785
2017 (2), 2016 (1), R01AI081558 (1)