8 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 7 Not applicable, 2 Phase 1, 2 Phase 2, 1 Early Phase 1, 1 Phase 3.
Follow Placebo gum: new trials by email Literature Review of Placebo gum trials Research Report on Placebo gum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Not yet recruiting | Xianhui Wang | 20 | 2026-11-01 | 2026-10-21 |
| Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Completed | San Diego State University | 29 | 2026-03-25 | 2026-10-16 |
| Caffeinated Gum Use and Volleyball Performance Single-dose caffeinated gum, Partial-dose caffeinated gum, Placebo gum - Volleyball Players, Performance | Not applicable | Completed | Ege University | 11 | 2025-08-05 | 2026-05-19 |
| Caffeine Optimization Versus Standard Caffeine Dosage (2B-2) Caffeine Gum, Placebo Gum - Sleep Deprivation, Caffeine | Not applicable | Recruiting | University of Arizona | 180 | 2023-06-09 | 2025-11-04 |
| Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex Nicotine gum, Placebo gum - Aging | Early Phase 1 | Completed | University of California, Berkeley | 44 | 2022-06-06 | 2026-07-24 |
| Using Nicotine to Reverse Age-related Auditory Processing Deficits Nicotine gum, Placebo gum - Auditory Perceptual Impairment, Aging | Not applicable | Recruiting | University of California, Irvine | 48 | 2022-02-01 | 2026-10-19 |
| Studying the Role of Brain Molecules for Decision Making Methylphenidate, Reboxetine, Nicotine gum - Decision Making, Healthy | Not applicable | Completed | University of Zurich | 160 | 2020-12-17 | 2024-05-08 |
| Energy Drinks and Vascular Function energy drink, caffeinated drink, Energy gum - Vascular Function | Not applicable | Completed | University of Florida | 19 | 2018-01-12 | 2019-05-20 |
| Impact of Sleep Deprivation and Caffeine in Medical Professionals Military Energy Gum, Placebo Gum - Sleep Deprivation, Performance | Not applicable | Terminated | Walter Reed Army Institute of Research (WRAIR) | 7 | 2017-07-06 | 2025-05-21 |
| Does a Caffeine Gum Improve 5 km Run Performance in a Competition/Field Setting? caffeine gum, placebo gum - Running Performance | Not applicable | Completed | Sheffield Hallam University | 36 | 2015-06-01 | 2016-04-19 |
| Combination Nicotine Replacement for Alcoholic Smokers Cognitive Behavior Therapy for alcohol and smoking cessation, Nicoderm CQ nicotine patch, Placebo gum - Smoking, Alcoholism | Phase 4 | Completed | Yale University | 96 | 2002-08-01 | 2021-08-13 |
| Smoking Reduction or Cessation With Nicotine Replacement Therapy Nicotine gum, Placebo gum, Nicotine inhaler - Smoking Cessation | Phase 3 | Completed | McNeil AB | 314 | 1999-02-01 | 2012-04-25 |
Sleep Deprivation (2) · Tinnitus (2) · Alcoholism (1) · Auditory perceptual impairment (1) · Smoking (1) · Smoking Cessation (1)
Ege University (1) · McNeil AB (1) · San Diego State University (1) · Sheffield Hallam University (1) · University of Arizona (1) · University of California, Berkeley (1) · University of California, Irvine (1) · University of Florida (1) · University of Zurich (1) · Walter Reed Army Institute of Research (WRAIR) (1) · Xianhui Wang (1) · Yale University (1)
United States (8) · Czechia (1) · Switzerland (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Xianhui Wang (2) · Anthony Lynn, PhD (1) · Demetra Christou, PhD (1) · Elisabeth Kruse, PhD (1) · Fan-Gang Zeng, PhD (1) · Michael A Silver, PhD (1) · Ned Cooney, PhD (1) · Philippe Tobler, PhD (1)
PMID 31832719, PMID 37639601, PMID 38400919
R01AG067073 (2), R01AA011197 (1)