7 completed, 3 recruiting, 1 terminated. 4 Not applicable, 2 Phase 3, 2 Phase 4, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Completed 4 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 4 | 2 | Completed 1, Recruiting 1 |
| Early Phase 1 | 1 | Recruiting 1 |
| Phase 1 | 1 | Terminated 1 |
| Phase 2 | 1 | Completed 1 |
Follow Phentolamine Mesylate: new trials by email Literature Review of Phentolamine Mesylate trials Research Report on Phentolamine Mesylate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children OraVerse - Soft Tissue Injuries | Phase 3 | Recruiting | Cairo University | 100 | 2025-07-05 | 2025-07-10 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Sex Disparities in Hypoxic Vasodilation and Impact of Obesity Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate - Obesity, Vasodilation | Early Phase 1 | Recruiting | University of Missouri-Columbia | 72 | 2023-03-14 | 2026-07-28 |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems Albuterol Sulfate, Nicardipine Hydrochloride, Dobutamine Hydrochloride - Drug-Related Side Effects and Adverse Reactions, Cardiovascular System Disease | Phase 1 | Terminated | Cambridge University Hospitals NHS Foundation Trust | 18 | 2017-04-24 | 2021-03-22 |
| Reversing the Effects of 0.5% Bupivacaine OraVerse, Saline Water (Control) - Anesthesia, Local | Phase 4 | Completed | Dalhousie University | 44 | 2017-02-10 | 2020-01-29 |
| Reversing the Effects of 2% Lidocaine Phentolamine mesylate, Water - Soft Tissue Anaesthesia | Not applicable | Completed | Dalhousie University | 38 | 2015-10-01 | 2016-10-14 |
| Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Low-dose rtPA, Standard-dose rtPA, Intensive blood pressure (BP) lowering - Ischemic Stroke, High Blood Pressure | Phase 3 | Completed | The George Institute | 4587 | 2012-03-01 | 2021-10-13 |
| The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Blood pressure management policies - Intracerebral Hemorrhage, Stroke | Not applicable | Completed | The George Institute | 2839 | 2008-09-01 | 2013-12-13 |
| Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Labetalol Hydrochloride, Metoprolol tartrate, Hydralazine Hydrochloride - CVA (Cerebrovascular Accident), Cerebral Hemorrhage | Not applicable | Completed | The George Institute | 404 | 2005-11-01 | 2008-06-26 |
| Nerve-Sparing Radical Prostatectomy With or Without Nerve Grafting Followed by Standard Therapy for Erectile Dysfunction in Treating Patients With Localized Prostate Cancer Alprostadil (E1), Papaverine, Phentolamine mesylate - Prostate Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 111 | 2001-08-01 | 2012-07-30 |
Aneurysm (3) · Cerebral Hemorrhage (2) · Hypertension (2) · Stroke (2) · Cardiovascular Diseases (1) · Drug-Related Side Effects and Adverse Reactions (1) · Infertility (1) · Intracranial Hemorrhages (1) · Ischemic Stroke (1) · Obesity (1) · Postoperative Complications (1) · Prostatic Neoplasms (1) · Sexual Dysfunction, Physiological (1) · Sexuality (1) · Soft Tissue Injuries (1)
The George Institute (3) · Dalhousie University (2) · University of Alberta (2) · Cairo University (1) · Cambridge University Hospitals NHS Foundation Trust (1) · M.D. Anderson Cancer Center (1) · University of Missouri-Columbia (1)
Canada (4) · Australia (3) · United States (3) · China (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Belgium (1) · Brazil (1) · Chile (1) · Egypt (1) · Finland (1) · France (1) · Germany (1) · Hong Kong (1)
Craig Anderson, PhD (2) · Sean van Diepen, MD, MSc (2) · Bruce Neal, PhD (1) · Christopher G. Wood, MD (1) · Craig D Steinback, PhD (1) · Craig S Anderson, MD (1) · Craig Steinback, PhD (1) · Jacqueline Limberg, Ph.D. (1) · Joseph Cheriyan, MBCHB, MA, FRCP (1) · Pierre-Luc Michaud, DMD, MSc, FRCDC (1) · Pierre-Luc Michaud, MSc (1)
PMID 32640944, PMID 25503550, PMID 25589782, PMID 25657175, PMID 25712944, PMID 25823544, PMID 26746184, PMID 27165954, PMID 27178897, PMID 27919055, PMID 30890109, PMID 31085948, PMID 33598552, PMID 38018833, PMID 40541207, PMID 41855454, PMID 42848972, PMID 18396107, PMID 18783876, PMID 20823381, PMID 22129475, PMID 22678090, PMID 22744655, PMID 23713578, PMID 24149007, PMID 24530176, PMID 25497513, PMID 25677598, PMID 25801872, PMID 26044442, PMID 26202097, PMID 26265125, PMID 26810526, PMID 26814235, PMID 26846860, PMID 26859491, PMID 27009893, PMID 27073236, PMID 27143274, PMID 27161018, PMID 27831492, PMID 28235817, PMID 28619989, PMID 28739832, PMID 28973174, PMID 29185557, PMID 29402064, PMID 29571842, PMID 29571953, PMID 29777016
P30CA016672 (1), P50CA090270 (1)