4 completed, 1 terminated. 4 Phase 2, 1 Phase 1.
By phase and status
Follow PF-00489791: new trials by email Literature Review of PF-00489791 trials Research Report on PF-00489791
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
A Study to Estimate the Effect of CYP3A4 Inhibitors (Itraconazole, Diltiazem or Verapamil) on the Pharmacokinetics of Single Dose PF- 00489791 in Healthy Volunteers
itraconazole, diltiazem, SR verapamil - Healthy Volunteers | Phase 1 | Completed | Pfizer | 22 | 2014-07-01 | 2016-09-16 |
A Phase 2, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of PF-00489791 In Patients With Type 2 Diabetes And Overt Nephropathy
PF-00489791, Placebo - Diabetic Nephropathies | Phase 2 | Completed | Pfizer | 256 | 2010-12-01 | 2019-03-12 |
PF-00489791 For The Treatment Of Raynaud's
PF-00489791 - Raynaud's Disease, Peripheral Vascular Disease | Phase 2 | Completed | Pfizer | 243 | 2010-08-04 | 2018-05-16 |
A Research Study To Assess The Effectiveness And Safety Of Different Doses Of Oral PF-00489791 In The Treatment Of Adult Patients With Pulmonary Arterial Hypertension
PF-00489791, placebo, sildenafil - Hypertension, Pulmonary | Phase 2 | Terminated | Pfizer | 48 | 2009-04-01 | 2017-10-24 |
A Dose Finding Study Of PF-00489791 In Patients With Mild To Moderate High Blood Pressure
placebo, PF-00489791 - Hypertension | Phase 2 | Completed | Pfizer | 135 | 2007-02-27 | 2021-10-11 |
Conditions studied
Diabetic Nephropathies (1) · Hypertension (1) · Hypertension, Pulmonary (1) · Peripheral Vascular Diseases (1) · Raynaud Disease (1) · Renal Insufficiency, Chronic (1) · Scleroderma, Diffuse (1) · Scleroderma, Systemic (1)
Sponsors
Pfizer (5)
Countries
United States (4) · Canada (3) · Sweden (3) · Germany (2) · India (2) · Mexico (2) · Poland (2) · South Korea (2) · Spain (2) · Australia (1) · Belgium (1) · Colombia (1) · Czechia (1) · Denmark (1) · Hong Kong (1)
Results publications
PMID 33998674
NIH funding
2008 (1), 2014 (1)