19 completed, 4 unknown, 3 terminated. 11 Not applicable, 11 Phase 4, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 8, Terminated 2, Unknown 1 |
| Phase 4 | 11 | Completed 7, Unknown 3, Terminated 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow NuvaRing: new trials by email Literature Review of NuvaRing trials Research Report on NuvaRing
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-label, Randomized, 2-Period, Crossover, Pharmacokinetics Study LSP-5415 (etonogestrel/ethinyl estradiol vaginal ring), NuvaRing Vaginal Ring - Pregnancy Prevention | Phase 2 | Completed | Lupin Research Inc | 40 | 2022-02-24 | 2022-07-19 |
| Does Vaginal Delivery of Combined Hormonal Contraception Affect the Risk of Metabolic Syndrome in Overweight/Obese Women With PCOS Etonogestrel/ethinyl estradiol vaginal ring - Polycystic Ovary Syndrome | Phase 4 | Completed | Andrea Roe, MD, MPH | 22 | 2020-09-03 | 2026-09-28 |
| Application for the Etonogestrel/Ethinyl Estradiol Ring Etonogestrel/ethinyl estradiol contraceptive vaginal ring - Emergency Contraception, Healthy, Reproductive Age Women | Phase 4 | Unknown | University of Southern California | 36 | 2017-07-10 | 2017-07-18 |
| Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity NuvaRing - Bacterial Vaginosis, HIV | Phase 4 | Completed | University of Washington | 120 | 2016-05-01 | 2018-12-10 |
| Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity NuvaRing - Bacterial Vaginosis | Phase 4 | Completed | University of Washington | 81 | 2016-03-01 | 2025-02-05 |
| A Study to Evaluate the Acceptability and Preference for Contraceptive Options as Proxy for HIV Prevention Methods Nur-Isterate, Nuvaring, Triphasil - HIV | Not applicable | Unknown | Desmond Tutu HIV Centre | 131 | 2015-07-01 | 2019-02-11 |
| Evaluating Pharmacokinetic Interactions With Vaginal Ring Contraceptives and ART Nuvaring, EFV, ATV/r - HIV-1 Infection | Phase 2 | Completed | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 84 | 2014-12-30 | 2018-06-06 |
| Performance and Safety of Vaginal Ring Applicator in Healthy Females (MK-8342A-063) Placebo vaginal ring, Single-use, non-sterile applicator - Contraception: Optional Applicator for Insertion of Vaginal Ring | Phase 3 | Completed | Organon and Co | 164 | 2014-12-11 | 2024-05-17 |
| Study of Nuvaring Acceptability, Adherence and Biological Effects Among HIV-negative Women in Kenya Nuvaring - Hormonal Contraception | Not applicable | Completed | Centers for Disease Control and Prevention | 200 | 2014-04-01 | 2015-08-20 |
| NuvaRing Versus Marvelon in the Coordination of In Vitro Fertilization Cycles Contraceptives, Oral, Contraceptive, Vaginal ring - Infertility | Phase 4 | Terminated | Clinique Ovo | 7 | 2012-07-01 | 2015-07-27 |
| Study of the Use of a Contraceptive Vaginal Ring (NuvaRing) in Normal Daily Practice in Indian Women (P07733) Ethinylestradiol + Etonogestrel Vaginal Ring (NuvaRing) - Contraception | Phase 4 | Completed | Organon and Co | 252 | 2011-12-26 | 2024-05-24 |
| Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring - Vaginosis, Bacterial | Phase 4 | Unknown | Eastern Virginia Medical School | 30 | 2011-10-01 | 2012-04-24 |
| A Study to Evaluate the Effectiveness of NuvaRing® to Prevent Pregnancies in Chinese Women (P06450) ENG 120 µg + EE 15 µg intravaginal ring, DRSP 3 mg + EE 30 µg - Contraception | Phase 3 | Completed | Organon and Co | 983 | 2011-09-19 | 2024-06-20 |
| New Treatments for Troublesome Bleeding in Implanon Users Marvelon - Menstrual Problem | Phase 4 | Unknown | Family Planning Association New South Wales | 200 | 2011-07-01 | 2011-06-29 |
| Acceptability of the NuvaRing Among Students Ortho Tri-cyclen Lo, NuvaRing - Birth Control Compliance | Phase 4 | Completed | University of Chicago | 273 | 2008-07-01 | 2021-02-03 |
| Efficacy of Combined Contraceptive Vaginal Ring(NuvaRing)in Women With Idiopathic Menorrhagia NuvaRing, Norethisterone Acetate tablets - 5mg - Menorrhagia | Not applicable | Completed | Mansoura University | 95 | 2008-07-01 | 2010-12-24 |
| Comparison of Serum Contraceptive Hormone Levels Between Normal Weight and Obese Users of the NuvaRing® NuvaRing - Pharmacokinetics | Not applicable | Completed | Columbia University | 40 | 2008-06-01 | 2015-04-30 |
| Mid-luteal Phase Synchronization of Ovarian Folliculogenesis in Women Marvelon, Nuvaring, Letrozole - Ovarian Follicle | Not applicable | Completed | University of Saskatchewan | 41 | 2007-11-01 | 2010-04-22 |
| The Effect of Hormonal Contraceptives on Androgens and Glucose Metabolism Desogestrel-Ethinyl Estradiol contraceptive pill, Etonogestrel-Ethinyl Estradiol vaginal ring, Norelgestromin-Ethinyl Estradiol contraceptive patch - Contraception | Not applicable | Completed | University of Oulu | 45 | 2007-10-01 | 2011-09-07 |
| Hormonal Contraception and Vaginal Health Desogen (ethinyl estradiol and desogestrel), NuvaRing (ethinyl estradiol and etonogestrel) - Contraceptive Usage, Vaginal Epithelial Disruption | Not applicable | Completed | Oregon Health and Science University | 14 | 2007-05-01 | 2012-11-08 |
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Vaginosis, Bacterial (3) · Infertility (2) · Contraception Behavior (1) · Headache (1) · Menorrhagia (1) · Menstruation Disturbances (1) · Metrorrhagia (1) · Obesity (1) · Patient Compliance (1) · Pelvic Pain (1) · Polycystic Ovary Syndrome (1) · Vaginitis (1)
Organon and Co (4) · University of Washington (2) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (1) · Andrea Roe, MD, MPH (1) · Centers for Disease Control and Prevention (1) · Clinique Ovo (1) · Columbia University (1) · Desmond Tutu HIV Centre (1) · Eastern Virginia Medical School (1) · Family Planning Association New South Wales (1) · Lupin Research Inc (1) · Mansoura University (1) · Oregon Health and Science University (1) · Scott and White Hospital & Clinic (1) · University Hospital, Ghent (1)
United States (11) · Canada (2) · Kenya (2) · South Africa (2) · Australia (1) · Belgium (1) · Botswana (1) · Brazil (1) · Egypt (1) · Finland (1) · India (1) · Peru (1) · Puerto Rico (1) · Thailand (1)
Andrea Roe, MD MPH (1) · Beatrice Nyagol, MN (1) · Carolyn Westhoff, MD, MSc (1) · Christine Johnston, MD, MPH (1) · Diana Crabtree Sokol, MD (1) · Edith Weisberg, MB BS MM (1) · Eleanor McLellan-Lemal, PhD (1) · Hatem Abu Hashim, MD MRCOG (1) · Jacques Kadoch, MD (1) · Jeanne M Marrazzo, MD, MPH (1) · Jeffrey T Jensen, MD., MPH (1) · Johanna M. Puurunen, MD (1) · Juha S. Tapanainen, Professor (1)
PMID 16102549, PMID 18238962, PMID 18976753, PMID 20177280, PMID 21880278, PMID 22811306, PMID 23260855, PMID 27207028, PMID 27339759, PMID 31498109, PMID 32989170, PMID 33034421, PMID 33149114, PMID 35348351, PMID 37919697
R01HD077872 (1), U19AI113173 (1), UM1AI068636 (1)