17 completed, 2 terminated, 1 unknown, 1 withdrawn. 3 Phase 1, 2 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Not applicable | 2 | Terminated 1, Withdrawn 1 |
| Phase 2 | 2 | Completed 2 |
Follow nucleic acid sequencing: new trials by email Literature Review of nucleic acid sequencing trials Research Report on nucleic acid sequencing
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Biomarkers in DNA Samples From Patients With High-Risk Acute Lymphoblastic Leukemia DNA analysis, genetic linkage analysis, microarray analysis - Leukemia | Completed | Children's Oncology Group | 350 | 2013-02-01 | 2016-07-11 | |
| Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor DNA methylation analysis, RNA analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction - Kidney Cancer | Completed | Children's Oncology Group | 40 | 2012-04-01 | 2016-05-18 | |
| Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma mutation analysis, nucleic acid sequencing, laboratory biomarker analysis - Sarcoma | Completed | Children's Oncology Group | 58 | 2012-04-01 | 2016-05-18 | |
| Studying DNA in Samples From Younger Patients With Down Syndrome and Acute Myeloid Leukemia Treated on COG-AAML0431 Clinical Trial gene mapping, microarray analysis, mutation analysis - Leukemia | Completed | Children's Oncology Group | 10 | 2012-02-01 | 2016-05-18 | |
| Studying Genes in Samples From Younger Patients With Adrenocortical Tumor DNA methylation analysis, RNA analysis, gene expression analysis - Adrenocortical Carcinoma | Completed | Children's Oncology Group | 10 | 2012-02-01 | 2016-05-18 | |
| Genetic Test To Identify Previously Undetectable Minimal Residual Disease in Cell Samples From Younger Patients With Acute Lymphoblastic Leukemia cytogenetic analysis, nucleic acid sequencing, diagnostic laboratory biomarker analysis - Leukemia | Completed | Children's Oncology Group | 12 | 2012-02-01 | 2016-05-18 | |
| Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression DNA methylation analysis, RNA analysis, mutation analysis - Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor | Completed | Children's Oncology Group | 90 | 2011-10-01 | 2016-05-18 | |
| Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1 DNA analysis, RNA analysis, gene expression analysis - Sarcoma | Completed | Children's Oncology Group | 20 | 2011-09-01 | 2016-05-18 | |
| Biomarkers in Samples From Adult Patients With Acute Myeloid Leukemia Who Failed Existing Standard-of-Care Treatment DNA methylation analysis, RNA analysis, gene expression analysis - Leukemia | Unknown | National Cancer Institute (NCI) | 400 | 2011-09-01 | 2013-07-10 | |
| Biomarker Study of Chemotherapy Resistance and Outcomes in Samples From Older Patients With Acute Myeloid Leukemia DNA methylation analysis, RNA analysis, gene expression analysis - Leukemia | Completed | Eastern Cooperative Oncology Group | 257 | 2011-08-17 | 2017-05-17 | |
| Combination Chemotherapy and Pralatrexate as First-Line Therapy in Treating Patients With Non-Hodgkin Lymphoma prednisone, cyclophosphamide, etoposide - Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma | Phase 2 | Completed | University of Nebraska | 34 | 2011-07-06 | 2023-09-22 |
| Biomarkers in Samples From Young Patients With Soft Tissue Sarcoma DNA analysis, RNA analysis, mutation analysis - Sarcoma | Completed | Children's Oncology Group | 20 | 2011-05-01 | 2016-05-18 | |
| Biomarkers in Tissue Samples From Young Patients With Liver Cancer RNA analysis, gene expression analysis, microarray analysis - Childhood Hepatoblastoma, Stage I Childhood Liver Cancer | Completed | Children's Oncology Group | 99 | 2011-04-01 | 2016-05-18 | |
| Dasatinib and Gemcitabine Hydrochloride or Gemcitabine Hydrochloride Alone in Treating Patients With Pancreatic Cancer Previously Treated With Surgery dasatinib, gemcitabine hydrochloride, laboratory biomarker analysis - Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas | Phase 2 | Completed | Translational Oncology Research International | 8 | 2011-01-13 | 2018-01-09 |
| Azacitidine in Treating Patients With Triple Negative Stage I-IV Invasive Breast Cancer That Can Be Removed By Surgery azacitidine, laboratory biomarker analysis, immunohistochemistry staining method - Recurrent Breast Cancer, Stage IA Breast Cancer | Not applicable | Withdrawn | University of Southern California | 2011-01-01 | 2014-02-06 | |
| RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia RNA analysis, nucleic acid sequencing, reverse transcriptase-polymerase chain reaction - Leukemia | Completed | Children's Oncology Group | 20 | 2010-10-01 | 2016-05-17 | |
| Pralatrexate and Fluorouracil in Treating Patients With Recurrent Solid Tumors pralatrexate, fluorouracil, laboratory biomarker analysis - Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | University of Nebraska | 29 | 2010-09-14 | 2023-12-26 |
| Combination Chemotherapy and Cetuximab or Bevacizumab in Treating Patients With Metastatic Colorectal Cancer fluorouracil, leucovorin calcium, oxaliplatin - Metastatic Colorectal Cancer | Not applicable | Terminated | Fox Chase Cancer Center | 3 | 2010-03-01 | 2021-03-15 |
| Lenalidomide And Rituximab as Maintenance Therapy in Treating Patients With B-Cell Non-Hodgkin Lymphoma lenalidomide, rituximab, polymerase chain reaction - Adult Non-Hodgkin Lymphoma, Adult Grade III Lymphomatoid Granulomatosis | Phase 1 | Terminated | Case Comprehensive Cancer Center | 5 | 2010-01-01 | 2015-11-26 |
| Study of Biomarkers in Blood and Bone Marrow Samples From Patients With Previously Untreated Chronic Lymphocytic Leukemia fluorescence in situ hybridization, mutation analysis, nucleic acid sequencing - Leukemia | Completed | Alliance for Clinical Trials in Oncology | 600 | 2009-10-01 | 2022-08-03 |
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Leukemia (7) · Sarcoma (3) · Congenital Abnormalities (2) · Leukemia, Erythroblastic, Acute (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Megakaryoblastic, Acute (2) · Leukemia, Monocytic, Acute (2) · Leukemia, Myeloid, Acute (2) · Leukemia, Myelomonocytic, Acute (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Adrenocortical Carcinoma (1) · Breast Neoplasms (1) · Burkitt Lymphoma (1) · Colonic Neoplasms (1) · Colorectal Neoplasms (1)
Children's Oncology Group (11) · University of Nebraska (3) · Alliance for Clinical Trials in Oncology (1) · Case Comprehensive Cancer Center (1) · Eastern Cooperative Oncology Group (1) · Fox Chase Cancer Center (1) · National Cancer Institute (NCI) (1) · Translational Oncology Research International (1) · University of Southern California (1)
United States (8)
Agustin Garcia, MD (1) · Alberto S. Pappo, MD (1) · Crystal Denlinger (1) · Elizabeth C. Reed, MD (1) · Gail Tomlinson, MD (1) · Gerard Zambetti, PhD (1) · James F. Amatruda, MD, PhD (1) · Jean Grem (1) · Jeffrey Taub, MD (1) · Jerry Radich, MD (1) · John C. Byrd, MD (1) · Julie M Vose (1) · Karin Michels, MD, PhD (1) · Michael Cleary, MD (1) · Norman J. Lacayo, MD (1)
P30CA036727 (2)