17 completed, 9 recruiting, 8 unknown, 3 active not recruiting. 22 Phase 2, 9 Not applicable, 6 Phase 1, 5 Phase 3, 2 Early Phase 1.
Follow Nicotinamide: new trials by email Literature Review of Nicotinamide trials Research Report on Nicotinamide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial) Nicotinamide, Standard Glaucoma Therapy - Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG) | Phase 2 | Not yet recruiting | University of Chicago | 96 | 2027-06-01 | 2026-10-13 |
| Multi Interventional Approaches to Mitigate HIV Reservoirs for the Sustained HIV Remission Without Antiretrovirals Maraviroc, Dolutegravir, Dendritic Cell Vaccine - Hiv, HIV I Infection | Phase 2 | Recruiting | Federal University of São Paulo | 70 | 2026-07-15 | 2026-08-19 |
| Comparative Evaluation of Nicotine Analogs Biospecimen Collection, Nicotine, 6-Methyl Nicotine - Tobacco-Related Carcinoma, Addiction | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 70 | 2026-05-29 | 2026-06-26 |
| Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide - Glaucoma | Phase 2 | Recruiting | Christopher Kai Shun Leung | 138 | 2025-05-19 | 2025-06-26 |
| Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls Nicotinamide, Placebo - Frailty, Fall | Phase 2 | Unknown | University of Chile | 60 | 2024-05-21 | 2024-06-20 |
| Study of the Efficacy and Safety of Nicotinamide in Patients With Liver Fibrosis (NICOFIB) Nicotinamide, Placebo - Fatty Liver, Obesity | Phase 2 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 30 | 2024-04-23 | 2025-11-18 |
| Tolerance and Efficacy Nicotinamide (Vitamin B3) in Dominant Optic Atrophy OPA1 Nicotinamide - Nicotinamide Adverse Reaction | Phase 2 / Phase 3 | Active not recruiting | University Hospital, Angers | 25 | 2024-01-23 | 2026-04-01 |
| Spatiotemporal Dimensions of Metabolism in Autochthonous Tumors of GBM Patients Surgical removal of the GBM tumor, d4-NAM infusion - Glioblastoma Multiforme | Active not recruiting | AdventHealth Translational Research Institute | 2 | 2023-09-11 | 2025-03-13 | |
| Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial Nicotinamide, Placebo - Non-melanoma Skin Cancer, Carcinoma, Squamous Cell | Phase 3 | Recruiting | Women's College Hospital | 396 | 2023-08-28 | 2026-10-13 |
| Study of the Efficacy and Safety of Nicotinamide in Patients With Friedreich Ataxia Nicotinamide, Placebo - Friedreich Ataxia | Phase 2 | Withdrawn | RWTH Aachen University | 2023-04-01 | 2024-01-24 | |
| Pilot Trial of Supplemental Vitamin A and Nicotinamide Vitamin A, Nicotinamide, Other: Placebo - Skin Cancer, Kidney Transplant Recipients | Early Phase 1 | Recruiting | Rhode Island Hospital | 30 | 2023-04-01 | 2026-03-20 |
| Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and II Periodontitis Vitamin B3 100 MG Oral Tablet, vitamin B9, Placebo - Periodontitis Stage I, Periodontal Diseases | Early Phase 1 | Unknown | Cairo University | 30 | 2022-07-01 | 2022-06-28 |
| The Glaucoma Nicotinamide Trial Nicotinamide, Placebo - Glaucoma | Not applicable | Recruiting | Umeå University | 660 | 2022-05-18 | 2023-07-27 |
| Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia With History of Non-melanoma Skin Cancers Nicotinamide, Placebo - Chronic Lymphocytic Leukemia, Non-melanoma Skin Cancer (NMSC) | Phase 2 | Recruiting | University of Utah | 86 | 2022-02-25 | 2026-11-12 |
| Nicotinamide and Glaucoma Nicotinamide - Glaucoma | Not applicable | Completed | Umeå University | 120 | 2021-10-16 | 2023-06-23 |
| Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression Psilocybin, Nicotinamide - Treatment-resistant Depression | Phase 2 | Completed | Central Institute of Mental Health, Mannheim | 144 | 2021-06-10 | 2025-01-20 |
| Absorption and Digestion Kinetics of Human Metabolites Spermidine, Nicotinamide, PEA - Postprandial Inflammation | Not applicable | Completed | University of California, Davis | 5 | 2021-04-08 | 2021-08-23 |
| Improvement of the Nutritional Status Regarding Nicotinamide (Vitamin B3) and the Disease Course of COVID-19 Nicotinamide, Placebo - COVID-19 | Not applicable | Completed | University Hospital Schleswig-Holstein | 900 | 2021-02-01 | 2022-11-08 |
| Nicotinamide to Prevent Delirium Nicotinamide, Placebo tablets - Delirium Confusional State | Not applicable | Unknown | University of Chile | 146 | 2021-01-21 | 2021-01-26 |
| Nicotinamide-based Supportive Therapy in Lymphopenia for Patients With COVID-19 nicotinamide - Covid19, Lymphopenia | Not applicable | Completed | Qiang Hu | 24 | 2020-03-01 | 2021-11-08 |
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Glaucoma (3) · Alzheimer Disease (2) · Anxiety Disorders (2) · COVID-19 (2) · Carcinoma, Basal Cell (2) · Carcinoma, Squamous Cell (2) · Dementia (2) · Malnutrition (2) · Neurodegenerative Diseases (2) · Non-alcoholic Fatty Liver Disease (2) · Obesity (2) · Renal Insufficiency, Chronic (2) · Acquired Immunodeficiency Syndrome (1) · Anemia, Sickle Cell (1) · Arthralgia (1)
Federal University of São Paulo (2) · Umeå University (2) · University of California, Irvine (2) · University of Chile (2) · Women's College Hospital (2) · AdventHealth Translational Research Institute (1) · Ain Shams University (1) · Cairo University (1) · Central Institute of Mental Health, Mannheim (1) · Centre Hospitalier Universitaire, Amiens (1) · Christopher Kai Shun Leung (1) · Columbia University (1) · EpiDestiny, Inc. (1) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (1) · Haydom Lutheran Hospital (1)
United States (16) · Germany (4) · Canada (3) · France (3) · Brazil (2) · Chile (2) · China (2) · Spain (2) · Sweden (2) · United Kingdom (2) · Austria (1) · Egypt (1) · Hong Kong (1) · Italy (1) · Pakistan (1)
Estomih Mduma (2) · Adeline Divoux, PhD (1) · Alan Yu, M.B., B.Chir (1) · Ameer Muhammad, MSc (1) · An-Wen Chan (1) · An-Wen Chan, MD DPhil (1) · Brody Holohan, PhD (1) · Charles S. Grob, MD (1) · Felipe H Salech Morales, MD-PhD (1) · Felipe Salech, MD PhD (1) · Fyezah Jehan (1) · Fyezah Jehan, MSc (1)
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