15 completed, 1 terminated. 16 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 16 | Completed 15, Terminated 1 |
| Phase 2 | 6 | Completed 5, Terminated 1 |
Follow napabucasin: new trials by email Literature Review of napabucasin trials Research Report on napabucasin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rollover Study to Provide Continued Access to Napabucasin for Patients Enrolled in Boston Biomedical-sponsored Protocols Napabucasin, Nab-paclitaxel, Gemcitabine - Oncology | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 7 | 2020-02-24 | 2023-11-08 |
| A Study to Evaluate the Mass Balance of 14C-Napabucasin in Healthy Adult Male Subjects napabucasin - ADME, Healthy | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 8 | 2018-05-18 | 2023-11-08 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Drug Interaction Potential of Napabucasin in Healthy Volunteers napabucasin, cytochrome P450 (CYP450) probe drugs or BCRP transporter substrate - Drug-drug Interactions | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 30 | 2017-06-30 | 2023-11-14 |
| Special Combination of BBI608 and Pembrolizumab Napabucasin, Pembrolizumab - Metastatic Colorectal Cancer | Phase 1 / Phase 2 | Terminated | Takayuki Yoshino | 55 | 2016-10-01 | 2021-09-05 |
| A Study of BBI608 Administrated With FOLFIRI + Bevacizumab in Adult Patients With Metastatic Colorectal Cancer BBI608, 5-FU, Irinotecan - Metastatic Colorectal Cancer | Phase 1 | Completed | Sumitomo Pharma Co., Ltd. | 4 | 2015-12-01 | 2022-04-12 |
| A Study of BBI608 Administered in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Cancers BBI608, Ipilimumab, Nivolumab - Cancer | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 104 | 2015-08-01 | 2023-11-14 |
| A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies BBI608, Dexamethasone, Bortezomib - Hematologic Malignancy | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 15 | 2015-05-01 | 2023-11-14 |
| A Study of BBI608 and BBI503 Administered in Combination to Adult Patients With Advanced Solid Tumors BBI608, BBI503 - Cancer, Advanced Solid Tumors | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 147 | 2015-04-01 | 2023-11-08 |
| A Study of BBI608 in Combination With Temozolomide in Adult Patients With Recurrent or Progressed Glioblastoma BBI608, Temozolomide - Glioblastoma | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 34 | 2015-03-01 | 2023-11-15 |
| A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma BBI608, Pemetrexed, Cisplatin - Malignant Pleural Mesothelioma, Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | Sumitomo Pharma Co., Ltd. | 28 | 2015-02-01 | 2022-04-12 |
| A Study of BBI608 Administrated With Sorafenib in Adult Patients With Advanced Hepatocellular Carcinoma BBI608, Sorafenib - Hepatocellular Carcinoma | Phase 1 | Completed | Sumitomo Pharma Co., Ltd. | 12 | 2015-02-01 | 2022-04-12 |
| A Study of BBI608 in Combination With Sorafenib, or BBI503 in Combination With Sorafenib in Adult Patients With Hepatocellular Carcinoma BBI608, BBI503, Sorafenib - Hepatocellular Carcinoma | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 97 | 2014-12-01 | 2023-11-15 |
| A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer BBI608, Nab-paclitaxel, Gemcitabine - Metastatic Pancreatic Adenocarcinoma | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 139 | 2014-08-01 | 2023-11-18 |
| A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer BBI608, Fluorouracil, Oxaliplatin - Advanced Gastrointestinal Cancer | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 495 | 2014-01-01 | 2023-11-15 |
| A Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies BBI608, Paclitaxel - Cancer | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 565 | 2011-04-01 | 2023-11-15 |
| A Study of BBI608 in Adult Patients With Advanced Malignancies BBI608 - Cancer, Advanced Malignancies | Phase 1 | Completed | Sumitomo Pharma America, Inc. | 87 | 2009-03-01 | 2023-11-14 |
Neoplasms (5) · Carcinoma, Hepatocellular (2) · Colorectal Neoplasms (2) · Digestive System Neoplasms (2) · Pancreatic Neoplasms (2) · Adenocarcinoma (1) · Adenoma, Islet Cell (1) · Carcinoma, Islet Cell (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Pancreatic Ductal (1) · Digestive System Diseases (1) · Endocrine Gland Neoplasms (1) · Glioblastoma (1) · Glioma (1) · Hematologic Neoplasms (1)
Sumitomo Pharma America, Inc. (12) · Sumitomo Pharma Co., Ltd. (3) · Takayuki Yoshino (1)
United States (12) · Japan (5) · Canada (4) · France (1) · Taiwan (1)
Boston Biomedical (1) · Claudia Lebedinsky, MD (1) · Takayuki Yoshino, Dr (1)
2019 (1)