7 completed, 1 terminated. 8 Phase 2, 6 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 7, Terminated 1 |
| Phase 1 | 6 | Completed 5, Terminated 1 |
Follow napabucasin: new trials by email Literature Review of napabucasin trials Research Report on napabucasin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modulation Of The Tumour Microenvironment Using Either Vascular Disrupting Agents or STAT3 Inhibition in Order to Synergise With PD1 Inhibition in Microsatellite Stable, Refractory Colorectal Cancer Nivolumab 10 MG/ML, BNC 105, BBI608 - Colorectal Cancer Metastatic | Phase 2 | Completed | Australasian Gastro-Intestinal Trials Group | 90 | 2018-09-06 | 2021-08-27 |
| Special Combination of BBI608 and Pembrolizumab Napabucasin, Pembrolizumab - Metastatic Colorectal Cancer | Phase 1 / Phase 2 | Terminated | Takayuki Yoshino | 55 | 2016-10-01 | 2021-09-05 |
| A Study of BBI608 in Combination With Temozolomide in Adult Patients With Recurrent or Progressed Glioblastoma BBI608, Temozolomide - Glioblastoma | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 34 | 2015-03-01 | 2023-11-15 |
| A Study of BBI608 in Combination With Pemetrexed and Cisplatin in Adult Patients With Malignant Pleural Mesothelioma BBI608, Pemetrexed, Cisplatin - Malignant Pleural Mesothelioma, Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | Sumitomo Pharma Co., Ltd. | 28 | 2015-02-01 | 2022-04-12 |
| A Study of BBI608 in Combination With Sorafenib, or BBI503 in Combination With Sorafenib in Adult Patients With Hepatocellular Carcinoma BBI608, BBI503, Sorafenib - Hepatocellular Carcinoma | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 97 | 2014-12-01 | 2023-11-15 |
| A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Advanced Gastrointestinal Cancer BBI608, Fluorouracil, Oxaliplatin - Advanced Gastrointestinal Cancer | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 495 | 2014-01-01 | 2023-11-15 |
| A Study of BBI608 in Adult Patients With Advanced Colorectal Cancer BBI608, Panitumumab, Capecitabine - Colorectal Cancer | Phase 2 | Completed | Sumitomo Pharma America, Inc. | 200 | 2012-03-01 | 2023-11-15 |
| A Study of BBI608 Administered With Paclitaxel in Adult Patients With Advanced Malignancies BBI608, Paclitaxel - Cancer | Phase 1 / Phase 2 | Completed | Sumitomo Pharma America, Inc. | 565 | 2011-04-01 | 2023-11-15 |
Colorectal Neoplasms (3) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Glioblastoma (1) · Glioma (1) · Mesothelioma, Malignant (1) · Neoplasms (1) · Thymus Neoplasms (1)
Sumitomo Pharma America, Inc. (5) · Australasian Gastro-Intestinal Trials Group (1) · Sumitomo Pharma Co., Ltd. (1) · Takayuki Yoshino (1)
United States (5) · Canada (3) · Japan (2) · Australia (1)
Boston Biomedical (1) · Claudia Lebedinsky, MD (1) · Niall Tebbutt, Prof (1) · Takayuki Yoshino, Dr (1) · William J. Edenfield, MD (1)