12 completed, 7 terminated, 1 unknown, 1 withdrawn. 11 Phase 1, 10 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 8, Terminated 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 10 | Completed 5, Terminated 4, Withdrawn 1 |
| Phase 3 | 2 | Terminated 2 |
Follow motesanib diphosphate: new trials by email Literature Review of motesanib diphosphate trials Research Report on motesanib diphosphate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigational Drug in Combination With Two Chemotherapy Drugs in Women With Locally Recurrent or Metastatic Breast Cancer Ixabepilone, Capecitabine, Motesanib - Breast Cancer, Metastatic Breast Cancer | Phase 1 / Phase 2 | Withdrawn | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 2013-12-01 | 2025-05-02 | |
| Study of Motesanib (AMG 706) in Combination With Paclitaxel and Carboplatin for Advanced Non-Squamous Non-Small Cell Lung Cancer Motesanib, Placebo, Paclitaxel - Carcinoma, Non-Small-Cell Lung | Phase 3 | Terminated | Takeda | 401 | 2012-07-01 | 2015-12-14 |
| Single Dose Study of [14C]-Labelled AMG 706 in Patients With Advanced Solid Tumors AMG 706 - Advanced Solid Tumors | Phase 1 | Completed | Amgen | 4 | 2009-05-01 | 2011-07-15 |
| AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors AMG 706, octreotide - Gastrointestinal Carcinoid Tumor, Islet Cell Tumor | Phase 2 | Completed | Eastern Cooperative Oncology Group | 46 | 2008-11-07 | 2023-07-05 |
| AMG 706 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer motesanib diphosphate - Fallopian Tube Cancer, Ovarian Cancer | Phase 2 | Terminated | Gynecologic Oncology Group | 23 | 2007-12-01 | 2018-01-11 |
| MONET1-MOtesanib NSCLC Efficacy and Tolerability Study AMG 706, placebo, paclitaxel - Non-Small Cell Lung Cancer | Phase 3 | Terminated | Amgen | 1450 | 2007-07-01 | 2015-09-07 |
| Effect of Different Doses of AMG 706 on the Gallbladder in Advanced Solid Tumors AMG 706 - Solid Tumors | Phase 1 | Completed | Amgen | 49 | 2007-02-01 | 2011-01-21 |
| A Phase 2 Trial of AMG 706 or Bevacizumab in Combination With Chemo for Advanced NSCLC Bevacizumab, AMG 706, Paclitaxel - Advanced Non-squamous NSCLC | Phase 2 | Terminated | Amgen | 186 | 2007-01-31 | 2018-01-04 |
| A Study of AMG 706 or Bevacizumab, in Combination With Paclitaxel Chemotherapy, as Treatment for Breast Cancer AMG 706 placebo, Bevacizumab, AMG 706 - Breast Neoplasms, Breast Tumors | Phase 2 | Terminated | Amgen | 282 | 2006-12-01 | 2015-10-15 |
| Phase1b to Evaluate Safety of AMG706 in Combination With Paclitaxel or Docetaxel for Breast Cancer Docetaxel, Paclitaxel, AMG 706 - Locally Recurrent and Metastatic Breast Cancer | Phase 1 | Completed | Amgen | 46 | 2006-03-01 | 2013-07-31 |
| An Open Label Treatment Extension Study of AMG 706 AMG 706 - Solid Tumors | Phase 2 | Terminated | Amgen | 94 | 2005-12-01 | 2015-10-15 |
| To Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 386 When Used in Combination With AMG 706, Bevacizumab, Sorafenib, or Sunitinib. Sorafenib, AMG 706, AMG 386 - Advanced Solid Tumors | Phase 1 | Completed | Amgen | 88 | 2005-12-01 | 2017-02-08 |
| Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors AMG 706 - Advanced Gastrointestinal Stromal Tumor | Phase 2 | Completed | Amgen | 35 | 2005-11-01 | 2014-02-27 |
| AMG 706 and Gemcitabine in Treating Patients With Advanced Solid Tumors or Lymphoma gemcitabine hydrochloride, motesanib diphosphate, pharmacological study - Lung Cancer, Lymphoma | Phase 1 | Unknown | Jonsson Comprehensive Cancer Center | 18 | 2005-10-01 | 2013-09-17 |
| A Phase 1b, Open-label, Dose-finding Study of AMG 706 in Combination With Gemcitabine and Erlotinib to Treat Subjects With Solid Tumors AMG 706 - Histologically or Cytologically Documented Solid Tumors | Phase 1 | Completed | Amgen | 57 | 2005-09-01 | 2011-01-21 |
| A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer AMG 706 - Thyroid Cancer | Phase 2 | Completed | Amgen | 184 | 2005-07-01 | 2013-10-09 |
| Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Panitumumab, Motesanib diphosphate, Paclitaxel - Lung Cancer, Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Completed | Amgen | 51 | 2005-01-01 | 2016-03-24 |
| Safety of AMG 706 Plus Panitumumab Plus Gemcitabine-Cisplatin in the Treatment of Patients With Advanced Cancer AMG 706, Panitumumab, Gemcitabine - Lung Cancer, Pancreatic Cancer | Phase 1 | Terminated | Amgen | 41 | 2004-12-01 | 2014-03-20 |
| Safety of AMG 706 Plus Panitumumab Plus Chemotherapy in the Treatment of Subjects With Metastatic Colorectal Cancer FOLFOX-4, AMG 706, Panitumumab (Part 1a only) - Rectal Cancer, Colon Cancer | Phase 1 | Completed | Amgen | 119 | 2004-12-01 | 2012-09-17 |
| Study of AMG 706 in Subjects With Advanced Gastrointestinal Stromal Tumors (GISTs) AMG 706 - Gastrointestinal Cancer | Phase 2 | Completed | Amgen | 138 | 2004-10-01 | 2013-04-29 |
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Carcinoma, Non-Small-Cell Lung (5) · Neoplasms (4) · Breast Neoplasms (3) · Lung Neoplasms (3) · Adenocarcinoma of Lung (1) · Adenocarcinoma, Bronchiolo-Alveolar (1) · Adenocarcinoma, Follicular (1) · Adenoma, Islet Cell (1) · Burkitt Lymphoma (1) · Carcinoma, Islet Cell (1) · Carcinoma, Medullary (1) · Carcinoma, Ovarian Epithelial (1) · Colonic Neoplasms (1) · Esophageal Neoplasms (1) · Fallopian Tube Neoplasms (1)
Amgen (16) · Eastern Cooperative Oncology Group (1) · Gynecologic Oncology Group (1) · Jonsson Comprehensive Cancer Center (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Takeda (1)
United States (4)
Carolyn Britten, MD (1) · Edith Mitchell, MD (1) · Mary Mulcahy, MD (1) · Russell J. Schilder, MD (1)
PMID 20838998, PMID 17557949, PMID 18596272, PMID 20739388, PMID 21429799, PMID 21791058, PMID 22872523, PMID 23679351, PMID 24419239, PMID 25314641, PMID 25772756, PMID 29853660
U10CA023318 (1)