8 completed, 1 not yet recruiting, 1 terminated. 3 Phase 2, 3 Phase 4, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 2, Terminated 1 |
| Phase 4 | 3 | Completed 2, Not yet recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
Follow methylphenidate HCl: new trials by email Literature Review of methylphenidate HCl trials Research Report on methylphenidate HCl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EEG Biomarkers for ADHD Stimulant Treatment methylphenidate HCl, Mixed amphetamine salts extended release - ADHD | Phase 4 | Not yet recruiting | Boston Children's Hospital | 220 | 2026-09-15 | 2026-06-16 |
| Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study Very Low Dose Quillivant XR, Low Dose Quillivant XR, Moderate Dose Quillivant XR - ADHD, Autism | Phase 4 | Completed | Seattle Children's Hospital | 36 | 2014-09-01 | 2017-08-01 |
| General Anesthesia Emergence Induced by Methylphenidate Methylphenidate HCl, Placebo - Delayed Emergence From Anesthesia | Phase 1 | Completed | Nicoleta Stoicea | 54 | 2014-05-01 | 2022-07-12 |
| A Pharmacokinetics and Safety of Methylphenidate HCl in Healthy Japanese Adult Male Volunteers Methylphenidate HCl - Healthy | Phase 1 | Completed | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | 10 | 2010-09-01 | 2014-05-16 |
| Methylphenidate HCl or Modafinil in Treating Young Patients With Excessive Daytime Sleepiness After Cancer Therapy methylphenidate hydrochloride, modafinil, placebo - Central Nervous System Tumor, Pediatric, Fatigue | Phase 2 | Terminated | University of South Florida | 1 | 2010-07-01 | 2014-02-21 |
| Treatment of Severe Childhood Aggression (The TOSCA Study) Methylphenidate HCl, Risperidone, Parent Management Training (PMT) - Attention Deficit Disorder With Hyperactivity | Phase 4 | Completed | Michael Aman | 168 | 2008-08-01 | 2017-07-26 |
| Effectiveness of Lobeline in Treating Symptoms of ADHD in Adult Patients Lobeline sulfate, Methylphenidate HCl, Placebo - Attention Deficit Disorder With Hyperactivity | Phase 2 | Completed | Yaupon Therapeutics | 13 | 2008-07-01 | 2013-06-20 |
| Efficacy, Safety and Tolerability of SPD485 in Children Aged 6-12 Diagnosed With ADHD Methylphenidate Transdermal System, Placebo, Concerta - Attention Deficit Disorder With Hyperactivity | Phase 2 | Completed | Noven Therapeutics | 128 | 2005-06-01 | 2015-07-09 |
| Safety and Efficacy of MTS Versus Concerta in Pediatric Patients (Aged 6-12 Years) With ADHD Methylphenidate Transdermal System, Placebo, Concerta - Attention Deficit Hyperactivity Disorder | Phase 3 | Completed | Noven Therapeutics | 282 | 2004-09-01 | 2015-06-25 |
| Long-term Safety and Effectiveness of OROS Methylphenidate HCl in Children With Attention Deficit Hyperactivity Disorder methylphenidate HCl - Attention Deficit Hyperactivity Disorder | Phase 3 | Completed | Alza Corporation, DE, USA | 2011-06-14 |
Attention Deficit Disorder with Hyperactivity (7) · Attention Deficit and Disruptive Behavior Disorders (2) · Autistic Disorder (1) · Central Nervous System Neoplasms (1) · Conduct Disorder (1) · Delayed Emergence from Anesthesia (1) · Dyskinesias (1) · Fatigue (1) · Hyperkinesis (1) · Multiple Endocrine Neoplasia Type 1 (1) · Neurodevelopmental Disorders (1) · Neurologic Manifestations (1) · Sleep Wake Disorders (1)
Noven Therapeutics (2) · Alza Corporation, DE, USA (1) · Boston Children's Hospital (1) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (1) · Michael Aman (1) · Nicoleta Stoicea (1) · Seattle Children's Hospital (1) · University of South Florida (1) · Yaupon Therapeutics (1)
United States (6)
Catherine A. Martin, MD (1) · Gerald Rosen, MD (1) · Kenneth D. Gadow, PhD (1) · Mark Stein, PhD (1) · Michael G. Aman, PhD (1) · Nicoleta Stoicea, MD, PhD (1) · Oscar G. Bukstein, MD, MPH (1) · Robert L. Findling, MD (1) · Tom Geller, MD (1)
PMID 16175106, PMID 18312050, PMID 19849639, PMID 20973706, PMID 22074813, PMID 24342385, PMID 25151418, PMID 25885010, PMID 25885011, PMID 25885012, PMID 26504369, PMID 27238065, PMID 27348211, PMID 29173736, PMID 31730370
R01MH077676 (1), R01MH077750 (1), R01MH077907 (1), R01MH077997 (1), R43MH081553 (1), U10CA081920 (1)