28 completed, 13 unknown, 4 not yet recruiting, 3 recruiting. 11 Not applicable, 8 Phase 2, 2 Phase 3, 1 Phase 1, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Not yet recruiting | Mayo Clinic | 80 | 2026-12-01 | 2026-10-05 |
| Prospective Clinical Database Construction for Liver Cancer Diagnosis and Treatment liver resection, Systemic therapy combined with locoregional interventions - Liver Cancer (Primary and Metastatic) | Recruiting | Tongji Hospital | 800 | 2026-01-01 | 2026-06-04 | |
| NON-COlorectal Liver METastases Undergoing Liver Resection liver resection - Liver Metastases | Not yet recruiting | Azienda Ospedaliero Universitaria Maggiore della Carita | 300 | 2025-01-01 | 2024-08-07 | |
| Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model Hepatic arterial infusion chemotherapy, Lenvatinib, Tislelizumab - HCC | Phase 2 | Recruiting | Chen Xiaoping | 160 | 2024-06-01 | 2025-05-01 |
| Efficacy and Safety of Neoadjuvant Therapy in Patients With Resectable HCC Screened by a Multimodal Deep Learning Model. HAIC + Tirelizumab +lenvatinib +liver resection, liver resection - HCC | Phase 4 | Not yet recruiting | Chen Xiaoping | 312 | 2024-05-01 | 2024-03-15 |
| Precision Recurrence Risk Assessment in Early-stage Hepatocellular Carcinoma liver resection - Hepatocellular Carcinoma (HCC) | Completed | Tongji Hospital | 579 | 2023-08-25 | 2025-06-29 | |
| FOLFOX-HAIC as Conversion Treatment for Initially Unresectable Colorectal Liver Metastasis FOLFOX (oxaliplatin, leucovorin, 5-fluorouracil [5FU]), hepatic arterial infusion chemotherapy (HAIC), Bevacizumab - Colorectal Liver Metastasis (CRLM) | Phase 2 | Recruiting | Tongji Hospital | 300 | 2023-05-01 | 2025-05-25 |
| Clinical Study of MRD Recurrence Monitoring After Surgical Resection of Hepatocellular Carcinoma Liver resection - HCC | Unknown | Anhui Provincial Hospital | 200 | 2022-09-30 | 2022-07-14 | |
| TACE/HAIC Combined With Lenvatinib and Sintilimab in Neoadjuvant Therapy for Intermediate-stage HCC TACE/HAIC, Lenvatinib, Sintilimab - Hepatocellular Carcinoma | Phase 2 / Phase 3 | Unknown | Third Affiliated Hospital, Sun Yat-Sen University | 90 | 2022-05-30 | 2023-10-13 |
| Watch and Wait and Surgical Treatment for Clinical Complete Responders After Non-Curative Therapy for Hepatocellular Carcinoma Liver Resection - Hepatocellular Carcinoma | Phase 2 | Completed | Sun Yat-sen University | 74 | 2022-05-05 | 2026-01-15 |
| Surgical Resection for Hepatocellular Carcinoma Liver Resection - Resectable Hepatocellular Carcinoma | Completed | Dr Cipto Mangunkusumo General Hospital | 91 | 2021-12-01 | 2023-08-28 | |
| Validation of the Classification for Resectability and Ablatability Criteria for the Treatment of Liver Only Colorectal Metastases Liver resection - Colorectal Adenocarcinoma Metastatic in the Liver | Completed | University Hospital, Linkoeping | 116 | 2021-11-01 | 2026-05-06 | |
| Comparing the Prognosis of Patients With HCC and PVTT Treated With Surgery Versus Locoregional Therapy. Liver resection, Locoregional therapy - Hepatocellular Carcinoma | Not applicable | Active not recruiting | Chen Xiaoping | 1076 | 2019-12-01 | 2025-07-16 |
| Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastases Liver resection - Liver Regeneration, Liver Metastases | Not applicable | Unknown | Vilnius University | 100 | 2019-09-01 | 2019-11-26 |
| Hepatocarcinoma Recurrence on the Liver Study - Part2 liver resection - Liver Cancer, Surgery | Not yet recruiting | University of Milano Bicocca | 3000 | 2019-09-01 | 2019-08-12 | |
| Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases Hepatectomy, Pembrolizumab, Vactosertib - Metastatic Malignant Neoplasm in the Liver, Stage IV Colorectal Cancer AJCC v8 | Phase 2 | Terminated | Chloe Atreya, MD, PhD | 6 | 2019-07-22 | 2025-12-31 |
| Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging Hepatectomy, PVE or ALPPS - Hepatectomy, Liver Failure | Unknown | University of Leeds | 134 | 2019-07-08 | 2021-01-22 | |
| The Effect of Analgesic Modalities on Long Term Outcomes Following Open Liver Resection Liver resection - Liver Cancer | Not applicable | Completed | University of Edinburgh | 160 | 2019-03-06 | 2024-05-22 |
| ERAS in Liver Surgery Liver resection - ERAS | Completed | University of Milano Bicocca | 126 | 2019-01-01 | 2022-10-28 | |
| Impact of Sarcopenia on Postoperative Outcomes of Patients Undergoing Liver Resection Liver resection - Liver Neoplasms, Sarcopenia | Completed | San Camillo Hospital, Rome | 251 | 2018-07-01 | 2019-12-24 |
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Carcinoma, Hepatocellular (21) · Liver Neoplasms (9) · Colorectal Neoplasms (7) · Recurrence (4) · Liver Diseases (3) · Cholangiocarcinoma (2) · Fibrosis (2) · Neoplasm Metastasis (2) · Rupture, Spontaneous (2) · Biliary Fistula (1) · Carcinoma (1) · Conversion Disorder (1) · Death (1) · Disease Progression (1) · Focal Nodular Hyperplasia (1)
Chen Xiaoping (4) · Huazhong University of Science and Technology (3) · Tongji Hospital (3) · University of Milan (3) · Azienda Ospedaliero Universitaria Maggiore della Carita (2) · Beaujon Hospital (2) · Humanitas Clinical and Research Center (2) · Sun Yat-sen University (2) · University of Milano Bicocca (2) · Anhui Provincial Hospital (1) · Assistance Publique - Hôpitaux de Paris (1) · Azienda Policlinico Umberto I (1) · Chinese University of Hong Kong (1) · Chloe Atreya, MD, PhD (1) · Dr Cipto Mangunkusumo General Hospital (1)
China (12) · France (6) · Italy (6) · United Kingdom (4) · United States (4) · Austria (2) · Germany (2) · Spain (2) · Hong Kong (1) · Indonesia (1) · Lithuania (1) · Morocco (1) · Netherlands (1) · New Zealand (1) · South Korea (1)
Matteo Donadon, MD, PhD (3) · Abdelkader Belkouchi, MD (1) · Bi-xiang Zhang, Prof, PHD (1) · Charing CN Chong, MBChB (1) · Chloe Atreya, MD, Ph.D. (1) · Daniel Azoulay, MD PhD (1) · Edith Fleischmann, M.D. (1) · Emad A. Ahmed, MD, PhD (1) · Fabrizio Romano, MD (1) · Giuseppe Maria Ettorre, Prof (1) · Gunnar Folprecht, Dr. (1) · Harry P van Goor, MD, PhD (1) · Ho-Seong Han, MD, PhD (1)
PMID 19541011, PMID 19942479, PMID 24277679, PMID 24585720, PMID 25217112, PMID 25243564, PMID 26148518, PMID 28083837, PMID 28192187, PMID 28406940, PMID 28585106, PMID 28842294, PMID 28935451, PMID 29140542, PMID 29149975, PMID 29254263, PMID 29373365, PMID 30003350, PMID 30401520, PMID 30701365, PMID 30704966, PMID 34688256, PMID 37037585, PMID 40772525, PMID 41775173
R01DK079879 (1), R01DK140085 (1)