5 completed, 2 active not recruiting, 2 recruiting, 2 unknown. 6 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 3, Active not recruiting 1, Not yet recruiting 1, Recruiting 1 |
| Phase 3 | 1 | Unknown 1 |
Follow Laparoscopic Nissen fundoplication: new trials by email Literature Review of Laparoscopic Nissen fundoplication trials Research Report on Laparoscopic Nissen fundoplication
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia | Recruiting | Minia University | 470 | 2026-09-20 | 2026-09-22 | |
| Comparison of Laparoscopic Nissen Fundoplication and Hill-Snow Repair for Hiatus Hernia With Endoscopic Evaluation Laparoscopic Hill-Snow repair, Laparoscopic Nissen Fundoplication - Hiatal Hernia With Gastroesophageal Reflux Disease | Not applicable | Not yet recruiting | Minia University | 40 | 2026-03-01 | 2026-02-04 |
| Comparative Analysis of Postoperative Manometry Outcomes in Nissen vs Toupet Fundoplication Laparoscopic Nissen Fundoplication, Laparoscopic Toupet fundoplication - GERD - Gastro-Esophageal Reflux Disease | Not applicable | Completed | Ain Shams University | 20 | 2024-03-10 | 2025-05-23 |
| Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia. Laparoscopic Nissen Fundoplication, Laparoscopic Toupet Fundoplication - Hiatal Hernia, Paraesophageal, Hiatal Hernia Large | Not applicable | Recruiting | Sofia Med Hospital | 200 | 2023-05-29 | 2026-07-22 |
| Antireflux Mucosal Ablation vs Fundoplication for Refractory GERD Modified Antireflux Mucosal Ablation (ARMA), Laparoscopic Nissen Fundoplication - Antireflux Mucosal Ablation, Laparoscopic Fundoplication Procedure | Completed | Minia University | 200 | 2023-01-01 | 2026-09-25 | |
| Multicenter Single-Blind RCT of CTIF Versus LNF For Treatment of GERD in Patients Requiring Hiatal Hernia Repair LAPAROSCOPIC PARAESOPHAGEAL HIATAL HERNIA REPAIR COMBINED WITH TRANSORAL INCISIONLESS FUNDOPLICATION - GERD, Hiatal Hernia | Not applicable | Active not recruiting | Mayo Clinic | 142 | 2021-01-26 | 2026-09-03 |
| A New System for GERD Diagnosis and Treatment Stretta, Laparoscopic Nissen fundoplication, Probiotic Agent - GERD | Unknown | Capital Medical University | 200 | 2019-02-01 | 2019-02-05 | |
| Development of Machine Learning Models to Predict Postoperative GERD Symptom Resolution After Laparoscopic Nissen Fundoplication Laparoscopic Nissen fundoplication - Gastroesophageal Reflux Disease (GERD), Gastroesophageal Reflux (GER) | Active not recruiting | Korea University Anam Hospital | 112 | 2017-02-01 | 2025-06-26 | |
| A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treating Gastroesophageal Reflux Disease Among Chinese Patients Laparoscopic Nissen Fundoplication, Laparoscopic anterior partial fundoplication - Gastroesophageal Reflux Disease | Phase 3 | Unknown | Chinese University of Hong Kong | 100 | 2006-11-01 | 2007-05-30 |
| Conventional Nissen Fundoplication Versus Laparoscopic Nissen Fundoplication Laparoscopic Nissen fundoplication, Open Nissen fundoplication - GERD | Not applicable | Completed | Turku University Hospital | 110 | 2004-12-01 | 2010-10-29 |
| Laparoscopic Total Fundoplication for Duodenogastroesophageal Reflux laparoscopic total fundoplication - Duodenogastric Reflux | Completed | University of Turin, Italy | 188 | 2002-06-01 | 2012-12-05 | |
| A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD Proton Pump Inhibitors, Laparoscopic Nissen Fundoplication - Gastroesophageal Reflux | Not applicable | Completed | McMaster University | 216 | 2000-01-01 | 2012-11-15 |
Gastroesophageal Reflux (10) · Hernia, Hiatal (4) · Barrett Esophagus (1) · Duodenogastric Reflux (1) · Esophagitis, Peptic (1)
Minia University (3) · Ain Shams University (1) · Capital Medical University (1) · Chinese University of Hong Kong (1) · Korea University Anam Hospital (1) · Mayo Clinic (1) · McMaster University (1) · Sofia Med Hospital (1) · Turku University Hospital (1) · University of Turin, Italy (1)
Egypt (4) · Bulgaria (1) · Canada (1) · Finland (1) · Hong Kong (1) · Italy (1) · South Korea (1) · United States (1)
Charles H. Goldsmith, PhD (1) · Chuan Zhang, MD (1) · Claudio Giaccone, MD (1) · David Armstrong, MB, BCh, MA (1) · Edward A Gadalla, MS (1) · Fabrizio Rebecchi, MD (1) · Marco Ettore Allaix, MD (1) · Mario Morino, MD (1) · Mehran Anvari, MB, BS, PhD (1) · Paulina Salminen, MD, PhD (1) · Philip W Chiu, FRCSEd (1) · Saleh K Saleh, MD (1)
PMID 11736981, PMID 24045453, PMID 28992673, PMID 35579516, PMID 37026848, PMID 37138589, PMID 39453844