17 completed, 6 unknown, 2 active not recruiting, 2 recruiting. 13 Phase 2, 10 Phase 3, 7 Phase 4, 3 Phase 1, 2 Not applicable.
Follow L-Asparaginase: new trials by email Literature Review of L-Asparaginase trials Research Report on L-Asparaginase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage vincristine, daunorubicin, cyclophosphamide - Acute Leukemia of Ambiguous Lineage | Phase 2 | Recruiting | Institute of Hematology & Blood Diseases Hospital, China | 50 | 2020-07-08 | 2025-08-06 |
| Ma-Spore ALL 2020 Study Prednisolone, Dexamethasone, Vincristine - B Lymphoblastic Leukemia | Phase 2 | Recruiting | National University Hospital, Singapore | 500 | 2020-03-04 | 2024-03-28 |
| Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone as 2nd-Line Treatment in PAC eryaspase, Gemcitabine plus Abraxane, Irinotecan plus 5-FU plus leucovorin - Pancreatic Adenocarcinoma | Phase 3 | Completed | ERYtech Pharma | 512 | 2018-09-15 | 2022-10-18 |
| Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Asparaginase, Cyclophosphamide, Doxorubicin Hydrochloride - B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma | Phase 2 | Withdrawn | University of Washington | 2018-07-01 | 2018-11-14 | |
| Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies Fludarabine, Cytarabine, Erwinase - Hematologic Malignancy | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2018-05-01 | 2018-06-26 | |
| SIMPLE Chemotherapy for NK Lymphoma/Leukaemia Cisplatin, Gemcitabine, Etoposide (VP-16) - Non-Hodgkin's Lymphoma, Relapsed, Non-Hodgkin T-cell Lymphoma | Phase 3 | Unknown | The University of Hong Kong | 68 | 2017-07-01 | 2018-08-14 |
| Combination Chemotherapy Including Cisplatin, Ifosfamide, Gemcitabine, L-asparaginase, Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell Lymphomas cisplatin, ifosfamide, gemcitabine - Peripheral T Cell Lymphoma | Phase 4 | Unknown | The University of Hong Kong | 50 | 2017-02-24 | 2018-06-11 |
| VP-16, Ifosfamide, Dexamethasone, L-asparaginase Chemotherapy in Patients With Extranodal Natural Killer T Cell Lymphoma (VIDL+ASCT) Etoposide, Ifosfamide, Dexamethasone - Extranodal NK-T-Cell Lymphoma | Phase 2 | Unknown | Samsung Medical Center | 27 | 2016-02-21 | 2020-10-22 |
| Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome Asparaginase, Asparaginase Erwinia chrysanthemi, Cytarabine - Acute Myeloid Leukemia, Down Syndrome | Phase 3 | Active not recruiting | Children's Oncology Group | 280 | 2015-12-23 | 2026-08-19 |
| Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia Allogeneic Hematopoietic Stem Cell Transplantation, Asparaginase, Blinatumomab - Recurrent B Acute Lymphoblastic Leukemia | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 669 | 2014-12-17 | 2026-10-21 |
| Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Asparaginase, Bortezomib, Cytarabine - Acute Myeloid Leukemia, Leukemia Cutis | Phase 3 | Completed | National Cancer Institute (NCI) | 1645 | 2011-07-06 | 2026-06-02 |
| Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Cyclophosphamide, Doxorubicin, Vincristine - Acute Lymphoblastic Leukemia | Phase 4 | Completed | Ruijin Hospital | 100 | 2010-12-01 | 2014-05-20 |
| GRASPA (Erythrocytes Encapsulating L-asparaginase) in Patients With Relapse of Acute Lymphoblastic Leukemia GRASPA, L-asparaginase - Acute Lymphoblastic Leukemia, in Relapse | Phase 2 / Phase 3 | Completed | ERYtech Pharma | 85 | 2009-12-01 | 2022-02-02 |
| Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224) Erwinase, Vincristine, Dexamethasone - Relapsed Acute Lymphoblastic Leukemia, Allergy to PEG e.Coli Asparaginase | Phase 1 | Terminated | Therapeutic Advances in Childhood Leukemia Consortium | 1 | 2009-04-13 | 2019-02-19 |
| Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma L-asparaginase, doxorubicin hydrochloride, therapeutic hydrocortisone - B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia | Phase 2 | Completed | National Cancer Institute (NCI) | 148 | 2009-03-01 | 2017-01-27 |
| Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Prednisolone, Dexamethasone, L-Asparaginase - Acute Lymphoblastic Leukemia (ALL) | Phase 4 | Unknown | National University Hospital, Singapore | 500 | 2008-10-01 | 2016-09-30 |
| Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Asparaginase, Cyclophosphamide, Cytarabine - Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 | Phase 2 / Phase 3 | Completed | National Cancer Institute (NCI) | 63 | 2008-07-14 | 2020-04-13 |
| L-asparaginase Monotherapy as Salvage Treatment in Patients With NK/T Cell Lymphoma L-asparaginase - Lymphoma | Phase 2 | Completed | Fudan University | 40 | 2008-06-01 | 2012-02-20 |
| Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia Asparaginase, Laboratory Biomarker Analysis, Pharmacological Study - Adult Acute Lymphoblastic Leukemia, Childhood Acute Lymphoblastic Leukemia | Not applicable | Completed | Children's Oncology Group | 59 | 2008-02-11 | 2019-07-09 |
| Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Asparaginase, Biospecimen Collection, Bone Marrow Biopsy - Acute Lymphoblastic Leukemia, Acute Undifferentiated Leukemia | Phase 3 | Completed | Children's Oncology Group | 218 | 2008-01-15 | 2024-07-15 |
Showing 20 of 31. Sign in to see all of them.
Precursor Cell Lymphoblastic Leukemia-Lymphoma (19) · Recurrence (5) · Lymphoma (4) · Burkitt Lymphoma (3) · Leukemia, Biphenotypic, Acute (3) · Leukemia, Myeloid, Acute (3) · Leukemia (2) · Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (2) · Down Syndrome (1) · Hematologic Neoplasms (1) · Hypersensitivity (1) · Leukemia, Prolymphocytic (1) · Lymphoma, B-Cell (1) · Lymphoma, Extranodal NK-T-Cell (1) · Lymphoma, Non-Hodgkin (1)
National Cancer Institute (NCI) (5) · Children's Oncology Group (4) · PETHEMA Foundation (4) · ERYtech Pharma (2) · Japan Adult Leukemia Study Group (2) · National University Hospital, Singapore (2) · The University of Hong Kong (2) · Therapeutic Advances in Childhood Leukemia Consortium (2) · Fudan University (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · M.D. Anderson Cancer Center (1) · Ruijin Hospital (1) · Rutgers, The State University of New Jersey (1) · Samsung Medical Center (1) · St. Jude Children's Research Hospital (1)
United States (15) · Australia (8) · Canada (8) · New Zealand (6) · Puerto Rico (6) · Spain (4) · China (3) · France (2) · Hong Kong (2) · Japan (2) · Malaysia (2) · Singapore (2) · Belgium (1) · Saudi Arabia (1) · South Korea (1)
Bastida Pilar, Dr (2) · Fumihiko Hayakawa, MD (2) · Tomoki Naoe, MD (2) · Yok Lam Kwong, MBBS (2) · Allen Eng Juh Yeoh, MBBS (1) · Allen Yeoh, MBBS (1) · Barton Kamen, MD (1) · Elizabeth Raetz, MD (1) · Heather Grossman, MD (1) · Jason N Berman (1) · Joanne M Hilden (1) · Manuel Hidalgo, MD, PhD (1) · Pascal Hammel, MD, PhD (1) · Patrick A Brown (1)
PMID 28419486, PMID 29812996, PMID 30044693, PMID 30138085, PMID 30773463, PMID 30957229, PMID 30987448, PMID 32029509, PMID 32414848, PMID 32552472, PMID 32813610, PMID 33242441, PMID 33651090, PMID 34302711, PMID 34596937, PMID 34855461, PMID 35349331, PMID 36603187, PMID 36815378, PMID 37257143, PMID 37267439, PMID 37276496, PMID 37556734, PMID 38295280, PMID 40294366, PMID 40533067, PMID 40568722, PMID 41124669, PMID 41187298, PMID 41592282, PMID 42085603, PMID 42085640
U10CA098543 (8), U10CA180886 (6), 2019 (1), P30CA015704 (1), P30CA072720 (1)