4 completed, 1 terminated, 1 withdrawn. 6 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 4, Terminated 1, Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
Follow KZR-616: new trials by email Literature Review of KZR-616 trials Research Report on KZR-616
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Zetomipzomib (KZR-616) in Patients With Active Lupus Nephritis (PALIZADE) zetomipzomib, placebo - Lupus Nephritis | Phase 2 | Terminated | Kezar Life Sciences, Inc. | 84 | 2023-11-03 | 2025-12-05 |
| A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA) zetomipzomib, placebo, zetomipzomib in open-label extension - Autoimmune Hepatitis | Phase 2 | Completed | Kezar Life Sciences, Inc. | 24 | 2023-05-23 | 2026-01-13 |
| Open-label Extension to the Phase 2 Crossover Study (PRESIDIO) Evaluating KZR-616 in Patients With PM and DM. KZR-616 - Polymyositis, Dermatomyositis | Phase 2 | Completed | Kezar Life Sciences, Inc. | 18 | 2020-11-04 | 2025-11-19 |
| A Phase 2 Study to Evaluate the Safety and Efficacy of KZR-616 in Patients With AIHA and ITP KZR-616 - Autoimmune Hemolytic Anemia, Immune Thrombocytopenia | Phase 2 | Withdrawn | Kezar Life Sciences, Inc. | 2020-07-01 | 2020-08-07 | |
| A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis KZR-616, Placebo - Polymyositis, Dermatomyositis | Phase 2 | Completed | Kezar Life Sciences, Inc. | 25 | 2020-01-14 | 2025-11-19 |
| A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis KZR-616 - Lupus Nephritis, Systemic Lupus Erythematosus | Phase 1 / Phase 2 | Completed | Kezar Life Sciences, Inc. | 69 | 2018-02-20 | 2025-11-18 |
Dermatomyositis (2) · Lupus Erythematosus, Systemic (2) · Lupus Nephritis (2) · Muscular Diseases (2) · Musculoskeletal Diseases (2) · Myositis (2) · Polymyositis (2) · Anemia (1) · Anemia, Hemolytic, Autoimmune (1) · Hematologic Diseases (1) · Hemolysis (1) · Hepatitis, Autoimmune (1) · Nephritis (1) · Purpura, Thrombocytopenic, Idiopathic (1) · Thrombocytopenia (1)
United States (6) · Australia (2) · Colombia (2) · Czechia (2) · Poland (2) · Russia (2) · Argentina (1) · Brazil (1) · China (1) · Germany (1) · Greece (1) · Guatemala (1) · India (1) · Italy (1) · Malaysia (1)
Craig Lammert, MD (1) · Ethan Weinberg, MD (1)