18 completed, 3 terminated, 1 active not recruiting, 1 unknown. 23 Phase 3, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Completed 18, Terminated 3, Active not recruiting 1, Unknown 1 |
| Phase 2 | 6 | Completed 4, Active not recruiting 1, Terminated 1 |
Follow Kaletra: new trials by email Literature Review of Kaletra trials Research Report on Kaletra
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir Lopinavir/ritonavir - Coronavirus Infections, Post-exposure Prophylaxis | Phase 3 | Unknown | Unity Health Toronto | 123 | 2020-04-17 | 2021-12-14 |
| Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers Hydroxychloroquine, Placebo of Hydroxychloroquine, Lopinavir and ritonavir - COVID-19 | Phase 3 | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 118 | 2020-04-14 | 2023-03-01 |
| Antiretroviral Regimens Containing Raltegravir for Prophylaxis of Mother-to-child-transmission of HIV Infection Raltegravir, Lopinavir/Ritonavir - HIV, Pregnancy | Phase 2 / Phase 3 | Terminated | Fundação Bahiana de Infectologia | 33 | 2015-06-01 | 2024-10-15 |
| Early Infant HIV Treatment in Botswana Nevirapine, Kaletra, Lamivudine - HIV, Pediatric AIDS | Phase 2 / Phase 3 | Active not recruiting | Harvard School of Public Health (HSPH) | 67 | 2015-05-04 | 2026-02-23 |
| Test Albuvirtide in Experienced Patients albuvirtide, lopinavir-ritonavir, tenofovir - HIV Infections, AIDS | Phase 3 | Completed | Frontier Biotechnologies Inc. | 418 | 2014-02-19 | 2021-10-06 |
| Study of Options for Second-Line Effective Combination Therapy (SELECT) Lopinavir/ritonavir, Raltegravir, Emtricitabine/tenofovir disoproxil fumarate - HIV-1 Infection | Phase 3 | Completed | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 515 | 2012-03-13 | 2021-08-05 |
| Human Immunodeficiency Virus (HIV) Postexposure Prophylaxis (PEP) With Darunavir/Ritonavir (DRV/r) Darunavir/Ritonavir (DRV/r), Lopinavir in fixed combination with Ritonavir, Zidovudine - Human Immunodeficiency Virus (HIV) | Phase 3 | Completed | Janssen-Cilag G.m.b.H | 312 | 2011-11-25 | 2017-07-19 |
| Effects of Intensive cART During Acute/Early HIV Infection raltegravir, maraviroc, emtricitabine 200mg /tenofovir 300mg - Acute HIV Infection | Phase 2 / Phase 3 | Completed | University of Toronto | 32 | 2011-11-01 | 2016-04-05 |
| Pediatric Study for Appropriate Dose of Ritonavir Boosted Lopinavir in Thai HIV-infected Children (PEARL) kaletra - HIV-infected Children | Phase 3 | Completed | The HIV Netherlands Australia Thailand Research Collaboration | 199 | 2011-03-01 | 2015-03-25 |
| A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines Lopinavir/ritonavir - HIV | Phase 2 / Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 97 | 2010-11-01 | 2021-11-05 |
| Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women Lopinavir/ritonavir, Efavirenz, Zidovudine - Malaria, HIV Infections | Phase 3 | Completed | University of California, San Francisco | 389 | 2009-12-15 | 2019-05-14 |
| Evaluation of a Lopinavir/Ritonavir Monotherapy vs a Triple Therapy as Maintenance Regimens in HIV-1 Infected Patients efavirenz/emtricitabin/tenofovir, lopinavir/ritonavir - HIV Infections | Phase 2 / Phase 3 | Completed | French National Agency for Research on AIDS and Viral Hepatitis | 420 | 2009-11-01 | 2014-06-24 |
| Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL) lopinavir/ritonavir (LPV/r), emtricitabine/tenofovir disoproxil fumarate (FTC/TDF), raltegravir (RAL) - Human Immunodeficiency Virus Infection | Phase 3 | Completed | Abbott | 206 | 2008-07-01 | 2012-02-14 |
| MK0518 in the Treatment of HIV-Infected Patients Switched From a Protease Inhibitor Regimen (0518-032)(TERMINATED) MK0518 (raltegravir), Comparator: KALETRA™ (lopinavir (+) ritonavir ), Comparator: placebo - HIV Infection | Phase 3 | Terminated | Merck Sharp & Dohme LLC | 352 | 2007-05-01 | 2017-03-21 |
| Ritonavir-boosted Lopinavir Monotherapy lopinavir/ritonavir soft gel capsule - HIV | Phase 3 | Completed | Bamrasnaradura Infectious Diseases Institute | 40 | 2007-04-01 | 2011-11-11 |
| Clinical Trial of CNS-targeted HAART (CIT2) FDA Approved Antiretroviral Therapy (see list below) - HIV Infections | Phase 2 / Phase 3 | Completed | University of California, San Diego | 59 | 2007-03-01 | 2014-04-23 |
| Study of Lopinavir/Ritonavir Tablets Comparing Once-Daily Versus Twice-Daily Administration When Coadministered With Nucleoside/Nucleotide Reverse Transcriptase Inhibitors in Antiretroviral-Experienced Human Immunodeficiency Virus Type 1 Infected Subjects lopinavir/ritonavir (LPV/r) tablet with nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) - Human Immunodeficiency Virus Infections | Phase 3 | Completed | Abbott | 599 | 2006-08-01 | 2011-04-11 |
| Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth Abacavir sulfate, Didanosine, Efavirenz - HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 377 | 2005-07-01 | 2021-11-02 |
| GEMINI Study - A Study of Saquinavir/Ritonavir in Treatment-Naive Patients With HIV-1 Infection saquinavir [Invirase], Lopinavir/ritonavir, Emtricitabine/tenofovir disoproxil fumarate - HIV Infections | Phase 3 | Completed | Hoffmann-La Roche | 337 | 2005-04-01 | 2011-11-02 |
| Preventing Sexual Transmission of HIV With Anti-HIV Drugs Atazanavir, Didanosine, Efavirenz - HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 3526 | 2005-02-01 | 2021-11-05 |
Showing 20 of 23. Sign in to see all of them.
HIV Infections (11) · Acquired Immunodeficiency Syndrome (4) · AIDS Dementia Complex (1) · COVID-19 (1) · Cognitive Dysfunction (1) · Coronavirus Infections (1) · Infections (1) · Malaria (1) · Occupational Injuries (1) · Pneumonia (1)
Abbott (4) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (1) · Bamrasnaradura Infectious Diseases Institute (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · French National Agency for Research on AIDS and Viral Hepatitis (1) · Frontier Biotechnologies Inc. (1) · Fundação Bahiana de Infectologia (1) · GlaxoSmithKline (1) · Harvard School of Public Health (HSPH) (1) · Hoffmann-La Roche (1) · Janssen-Cilag G.m.b.H (1) · Merck Sharp & Dohme LLC (1) · The HIV Netherlands Australia Thailand Research Collaboration (1) · Unity Health Toronto (1)
United States (8) · Thailand (6) · Canada (5) · France (5) · Brazil (4) · South Africa (3) · Botswana (2) · Germany (2) · India (2) · Italy (2) · Kenya (2) · Malawi (2) · Poland (2) · Puerto Rico (2) · Spain (2)
Thomas J Podsadecki, MD (2) · Alberto M La Rosa, MD (1) · Ann C Collier, MD (1) · Avy Violari, MBChB, FCPSA (1) · Bruno Hoen, MD, PhD (1) · Carlos Brites, MD, PhD (1) · Colin Kovacs, MD (1) · Daniel R. Kuritzkes, MD (1) · Darrell Tan, MD FRCPC PhD (1) · Deborah Cohan, MD, MPH (1) · Diane Havlir, MD (1) · Dong Xie (1) · Elisabeth Botelho-Nevers, MD, PhD (1)
PMID 19020325, PMID 19682100, PMID 20074791, PMID 21767103, PMID 22029910, PMID 22180523, PMID 22730929, PMID 22879899, PMID 23764539, PMID 23924639, PMID 24038035, PMID 24135775, PMID 24209829, PMID 24352352, PMID 24585398, PMID 24602844, PMID 24958908, PMID 25072616, PMID 25416075, PMID 25426808, PMID 25985404, PMID 26023212, PMID 26043884, PMID 26397935, PMID 26771662, PMID 27143666, PMID 27240787, PMID 27424812, PMID 27756308, PMID 27828878, PMID 28350554, PMID 29136115, PMID 29767684, PMID 29852062, PMID 30157702, PMID 30418528, PMID 30968368, PMID 31776292, PMID 31927562, PMID 32195745, PMID 32287064, PMID 32440638, PMID 33240091, PMID 33252379, PMID 33487029, PMID 33570583, PMID 33605999, PMID 33752741, PMID 34324451, PMID 35858580
2008 (1), 2009 (1), 5UM1AI068634 (1), P01HD059454 (1), R01AI062512 (1), R01MH058076 (1), U01AI068636 (1)