7 completed, 5 unknown, 4 terminated, 1 withdrawn. 8 Phase 3, 5 Not applicable, 5 Phase 2, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 8 | Completed 3, Terminated 3, Unknown 1, Withdrawn 1 |
| Not applicable | 5 | Unknown 4, Completed 1 |
| Phase 2 | 5 | Completed 2, Terminated 2, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Terminated 1 |
Follow Intravitreal bevacizumab: new trials by email Literature Review of Intravitreal bevacizumab trials Research Report on Intravitreal bevacizumab
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Ranibizumab Versus Bevacizumab on the Macular Perfusion in Diabetic Macular Edema Intravitreal ranibizumab, Intravitreal bevacizumab - Diabetic Macular Edema, Macular Ischemia | Phase 4 | Terminated | Cairo University | 5 | 2021-11-26 | 2023-02-16 |
| A Dosing Study of Intravitreal Bevacizumab for Retinopathy of Prematurity Intravitreal Bevacizumab - Retinopathy of Prematurity | Phase 3 | Completed | Cairo University | 19 | 2020-02-01 | 2023-02-03 |
| Comparison of Treatment Response to Intravitreal Injection of Combined Propranolol and Bevacizumab Versus Bevacizumab Monotherapy in Patients With Wet Age Related Macular Degeneration :A Clinical Trial Combined Intravitreal bevacizumab and propranolol, Intravitreal bevacizumab - Age Related Macular Degeneration | Phase 2 / Phase 3 | Unknown | Shahid Beheshti University of Medical Sciences | 40 | 2018-09-01 | 2018-08-01 |
| Randomized Clinical Trial of Intravitreal Bevacizumab Versus Intravitreal Bevacizumab Combined With Losartan in the Treatment of Diabetic Macular Edema Losartan, Intravitreal bevacizumab, Placebo - Diabetic Macular Edema | Phase 2 | Completed | Tehran University of Medical Sciences | 57 | 2015-06-01 | 2016-07-06 |
| Pre-Operative Intravitreal Bevacizumab for Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy Intravitreal bevacizumab, Small-gauge pars plana vitrectomy - Tractional Retinal Detachment Secondary to Proliferative Diabetic Retinopathy | Phase 3 | Completed | J. Fernando Arevalo, MD FACS | 224 | 2013-11-01 | 2018-10-09 |
| Ozurdex for Treatment of Recalcitrant Diabetic Macular Edema dexamethasone intravitreal implant, intravitreal bevacizumab - Diabetic Macular Edema, Non-proliferative Diabetic Retinopathy | Phase 2 | Completed | Retina Macula Institute | 20 | 2012-04-01 | 2021-03-30 |
| Effect of Intravitreal Anti-VEGF on Retinal Vessels Diameter Intravitreal Ranibizumab, Intravitreal bevacizumab - Age Related Macular Degeneration | Not applicable | Unknown | University of Malaya | 30 | 2012-04-01 | 2012-06-22 |
| Efficacy and Safety of Intravitreal Bevacizumab for Threshold ROP. Intravitreal Bevacizumab - Stage 2+ or Stage 3+ Retinopathy of Prematurity in Zone I or Zone II. | Not applicable | Unknown | Sivakami A Pai | 50 | 2010-01-01 | 2012-10-16 |
| Intravitreal Bevacizumab and Triamcinolone Associated to Laser Photocoagulation for Diabetic Macular Edema(IBeTA) Laser photocoagulation, Intravitreal triamcinolone, Intravitreal bevacizumab - Diabetic Macular Edema | Phase 3 | Completed | University of Sao Paulo | 12 | 2009-10-01 | 2013-03-04 |
| Major and Macular Branched Retinal Venous Occlusion intravitreal bevacizumab - Macular Edema | Not applicable | Completed | Hallym University Medical Center | 46 | 2008-03-01 | 2010-10-13 |
| Intravitreal Injection of Bevacizumab and Gas for Diabetic Premacular Hemorrhage With Active Fibrovascular Proliferation Intravitreal Bevacizumab - Diabetic Retinopathy With Premacular Hemorrhage | Not applicable | Unknown | National Taiwan University Hospital | 6 | 2007-01-01 | 2008-05-07 |
| Intravitreal Bevacizumab in Agioid Streaks intravitreal injection - Angioid Streaks, Choroidal Neovascularization | Phase 1 | Completed | University of Campania Luigi Vanvitelli | 5 | 2006-11-01 | 2016-02-08 |
| Intravitreal Bevacizumab for Polypoidal Choroidal Vasculopathy Intravitreal Bevacizumab - Polypoidal Choroidal Vasculopathy | Not applicable | Unknown | Asan Medical Center | 20 | 2006-05-01 | 2006-10-04 |
| Intravitreal Bevacizumab for Diabetic Retinopathy intravitreal bevacizumab - Severe Nonproliferative, Proliferative Diabetic Retinopathy | Phase 2 / Phase 3 | Terminated | Asociación para Evitar la Ceguera en México | 2005-12-01 | 2024-05-30 | |
| Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment Intravitreal Bevacizumab - Diabetic Proliferative Retinopathy, Vascular Vein Oclussion | Phase 2 / Phase 3 | Terminated | Asociación para Evitar la Ceguera en México | 2005-12-01 | 2024-06-03 | |
| Use of Intravitreal Bevacizumab in Eyes With Choroidal Neovascularization Secondary to Angioid Streaks Intravitreal Bevacizumab - Angioid Streaks, Choroidal Neovascularization | Phase 3 | Terminated | Asociación para Evitar la Ceguera en México | 2005-11-01 | 2024-06-03 | |
| Use of Intravitreal Bevacizumab in Patients With Diffuse Diabetic Macular Edema Intravitreal Bevacizumab - Diabetes Mellitus Type 2, Diabetic Macular Edema | Phase 3 | Withdrawn | Asociación para Evitar la Ceguera en México | 2005-09-01 | 2024-06-03 |
Choroidal Neovascularization (3) · Macular Edema (3) · Angioid Streaks (2) · Macular Degeneration (2) · Blood Loss, Surgical (1) · Diabetes Mellitus (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Retinopathy (1) · Polypoidal Choroidal Vasculopathy (1) · Retinopathy of Prematurity (1)
Asociación para Evitar la Ceguera en México (4) · Cairo University (2) · Asan Medical Center (1) · Hallym University Medical Center (1) · J. Fernando Arevalo, MD FACS (1) · National Taiwan University Hospital (1) · Retina Macula Institute (1) · Shahid Beheshti University of Medical Sciences (1) · Sivakami A Pai (1) · Tehran University of Medical Sciences (1) · University of Campania Luigi Vanvitelli (1) · University of Malaya (1) · University of Sao Paulo (1)
Mexico (3) · Egypt (2) · Iran (2) · South Korea (2) · Brazil (1) · Italy (1) · Malaysia (1) · Saudi Arabia (1) · Taiwan (1) · United Arab Emirates (1) · United States (1)
Griselda Alvarez-Rivera, MD (2) · Hugo Quiroz-Mercado, MD (2) · Jans Fromow-Guerra, MD PhD (2) · Ahmed A Abdel-Kader, MD, PhD (1) · Ahmed A Mohalhal, MD, PhD (1) · Ayman G Elnahry, MD, PhD (1) · Chung May Yang, M.D. (1) · Elizabeth Reyna-Castelan, MD (1) · Hyewon Chung, MD (1)
PMID 18682973, PMID 31139483, PMID 32411431, PMID 32427087, PMID 33784213, PMID 34124270, PMID 34189816