25 completed, 5 terminated, 5 withdrawn, 3 unknown. 14 Phase 4, 10 Not applicable, 8 Phase 3, 5 Phase 2, 4 Phase 1.
Follow Intralipid: new trials by email Literature Review of Intralipid trials Research Report on Intralipid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Reversing Glucose and Lipid-mediated Vascular Dysfunction Dextrose 20 % in 500 ML Injection, Intralipid, Saline - Blood Pressure, Hypertension | Early Phase 1 | Recruiting | University of Kansas Medical Center | 46 | 2022-05-09 | 2025-06-05 |
| Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion (Part A) Clinolipid, Intralipid - Essential Fatty Acid Deficiency (EFAD) | Phase 4 | Completed | Baxter Healthcare Corporation | 101 | 2021-01-22 | 2023-12-27 |
| The Cardioprotective Effect of Intralipid in Decreasing the Ischemic Insults During Off-pump Coronary Artery Revascularization Intralipid, Placebo - Anesthesia | Phase 4 | Completed | Ain Shams University | 46 | 2020-10-01 | 2021-03-19 |
| Effect of Fasting Free Fatty Acids and Fasting Glucose on 1st and 2nd Phase Insulin Secretion Somatostatin, Dextrose, Insulin - Healthy | Phase 4 | Withdrawn | Mayo Clinic | 2020-02-01 | 2022-09-09 | |
| Omega 3 Fatty Acid Treatment for Pediatric Musculoskeletal Health Omegaven, Intralipid - Esophageal Atresia | Phase 2 | Withdrawn | Boston Children's Hospital | 2019-09-01 | 2019-09-16 | |
| Intralipid Versus SMOFlipid in HPN Patients SMOFLipid, Intralipid - Short Bowel Syndrome, Intestinal Fistula | Not applicable | Completed | Mayo Clinic | 22 | 2018-12-31 | 2025-05-16 |
| Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids Intralipid, Palm Oil Emulsion, Saline - Insulin Resistance | Not applicable | Recruiting | Mayo Clinic | 60 | 2018-12-01 | 2026-01-12 |
| Early Higher Intravenous Lipid Intake in VLBW Infants Intravenous lipid emulsion - Very Low Birth Weight Infant | Not applicable | Completed | Belal Alshaikh | 83 | 2018-08-15 | 2021-12-21 |
| Fat Emulsion in Preventing Hypersensitivity Reactions in Patients With Cancer Receiving Carboplatin or Oxaliplatin Fat Emulsion, Placebo - Advanced Malignant Neoplasm | Not applicable | Completed | Mayo Clinic | 19 | 2017-07-14 | 2024-12-17 |
| Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion Intralipid - Recurrent Miscarriage | Phase 1 | Unknown | Ahmed Mohamed Bahaa Eldin Ahmed | 34 | 2017-05-01 | 2017-04-28 |
| Effects of Lipid Emulsion on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol. metoprolol, intravenous lipid emulsion, Sodium chloride 0.9% solution - lipid emulsion dummy - Drug Overdose, Overdose of Beta-adrenergic Blocking Drug | Phase 4 | Completed | Mikkel Bring Christensen | 10 | 2016-09-01 | 2017-04-12 |
| Patient-controlled Sedation With Propofol During Cataract Surgery Under Topical Anesthesia Propofol, Placebo - Sedation | Phase 4 | Completed | Fondation Ophtalmologique Adolphe de Rothschild | 60 | 2016-07-01 | 2017-07-28 |
| Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D) Intralipid, Saline - Insulin Resistance | Early Phase 1 | Completed | Pennington Biomedical Research Center | 25 | 2016-07-01 | 2021-07-27 |
| Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation Omegaven, Soybean oil lipid emulsion - Hematopoietic Stem Cell Transplantation | Phase 1 | Completed | Alexandra N. Carey | 20 | 2016-06-01 | 2025-09-22 |
| Reprometabolic Syndrome Mediates Subfertility in Obesity Insulin, Intralipid, Dextrose - Obesity, Infertility | Not applicable | Active not recruiting | University of Colorado, Denver | 84 | 2016-06-01 | 2026-03-02 |
| Carnitine Infusion and Insulin Resistance Carnitor, IntraLipid, Placebo - Glucose Intolerance | Not applicable | Terminated | Maastricht University Medical Center | 17 | 2016-05-01 | 2018-04-26 |
| Lipid Infusion Following Major Surgery Intralipid, Saline - Parenteral Nutrition | Not applicable | Withdrawn | University of Alberta | 2015-05-01 | 2020-03-25 | |
| Pediatric Study to Evaluate Risk of Developing Essential Fatty Acid Deficiency When Receiving Clinolipid or Standard-of-Care Lipid Emulsion Clinolipid, Intralipid - Essential Fatty Acid Deficiency (EFAD) | Phase 4 | Terminated | Baxter Healthcare Corporation | 1 | 2015-05-01 | 2021-07-21 |
| Racial Differences in Vagal Control of Glucose Homeostasis Galantamine, Placebo Oral Capsule, Intralipid - Obesity | Phase 1 / Phase 2 | Completed | Vanderbilt University Medical Center | 23 | 2015-03-01 | 2019-03-19 |
| Clevidipine vs Placebo or Standard of Care for Dyspnea and Blood Pressure Control in AHF Stage 1: Clevidipine (double-blinded), Stage 1: Placebo (double-blinded), Stage 2: Clevidipine (open-label) - Dyspnea, Hypertension | Phase 3 | Withdrawn | The Medicines Company | 2014-08-01 | 2020-10-19 |
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Hyperphagia (12) · Insulin Resistance (5) · Cholestasis (4) · Short Bowel Syndrome (4) · Abortion, Habitual (3) · Obesity (3) · Premature Birth (3) · Hypertension (2) · Infertility (2) · Inflammation (2) · Pena Shokeir syndrome, type 1 (2) · Retinopathy of Prematurity (2) · Abortion, Spontaneous (1) · Atrial Fibrillation (1) · Bites and Stings (1)
Mayo Clinic (4) · Baxter Healthcare Corporation (2) · Boston Children's Hospital (2) · Johane Allard (2) · Woman's Health University Hospital, Egypt (2) · Ahmed Mohamed Bahaa Eldin Ahmed (1) · Ain Shams University (1) · Alexandra N. Carey (1) · AstraZeneca (1) · Belal Alshaikh (1) · Beth Israel Deaconess Medical Center (1) · Cairo University (1) · Dr. Sami Ulus Children's Hospital (1) · Emory University (1) · Fondation Ophtalmologique Adolphe de Rothschild (1)
United States (19) · Canada (4) · Egypt (4) · China (3) · Austria (1) · Denmark (1) · France (1) · Japan (1) · Netherlands (1) · Russia (1) · Switzerland (1) · Turkey (Türkiye) (1)
Adrian Vella, MD (1) · Alaa M Ismail, M D (1) · Alexandra N Carey, MD (1) · Aminah Jatoi, M.D. (1) · Andreas Repa, MD (1) · Bara Ricou, Prof. (1) · Belal Alshaikh, MD,MSc (1) · Christopher Duggan, MD, MPH (1) · Christos S Mantzoros, MD, DSc (1) · Cyndya Shibao, MD (1) · Dina M Dakhly, M.D. (1) · Guillermo Umpierrez, MD (1) · Hassan T Khairy, Professor (1) · Johane P Allard, MD, FRCPC (1)
PMID 20473991, PMID 20531018, PMID 21199856, PMID 21832112, PMID 22237883, PMID 22639293, PMID 23770843, PMID 25027101, PMID 26561301, PMID 27614789, PMID 29269199, PMID 31030946, PMID 32590001, PMID 32798567, PMID 33838870, PMID 34090870, PMID 35659521, PMID 35961260, PMID 36257349, PMID 38710978, PMID 40415417, PMID 42615126
R01DK045343 (1), R01DK078646 (1), UG1CA189823 (1), UL1TR001082 (1)