76 completed. 76 Phase 2, 5 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 76 | Completed 76 |
| Phase 1 | 5 | Completed 5 |
| Phase 3 | 2 | Completed 2 |
Follow Interferon-alpha: new trials by email Literature Review of Interferon-alpha trials Research Report on Interferon-alpha
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmaco-immunological Study of Interferon-alpha and Metronomic Cyclophosphamide Association in Neuroendocrine Tumors Metronomic cyclophosphamide, Interferon-alpha - Neuroendocrine Tumors | Phase 2 | Completed | Centre Hospitalier Universitaire de Besancon | 28 | 2015-05-19 | 2021-08-02 |
| Adjuvant Therapy of Skin Melanoma With Alpha Interferon and Naderin Surgical resection, Adjuvant Radiotherapy, interferon alfa - Melanoma Stage I, Melanoma Stage III | Phase 2 | Completed | MIPO Clinic | 278 | 2014-01-01 | 2026-06-30 |
| Interferon Alpha Lozenges Plus Oseltamivir for Influenza Treatment Interferon-alpha, Oseltamivir, maltose - Influenza A Virus Infection | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 40 | 2011-01-01 | 2013-08-21 |
| Interferon-alpha Lozenges for Prevention of Relapse in Hepatitis C interferon-alpha lozenges, placebo lozenges - Hepatitis C, Chronic | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 169 | 2009-06-01 | 2024-02-21 |
| Interferon Alpha Lozenges in the Prevention of Winter Colds and Flu interferon-alpha, placebo - Upper Respiratory Tract Infections | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 200 | 2009-04-01 | 2011-09-16 |
| Borderline Resectable Pancreatic Cancer: Gemcitabine/Docetaxel and Oxaliplatin Based Chemo/RT Gemcitabine, Docetaxel, 5FU, Oxaliplatin, Alpha-interferon, Abdominal/pelvic radiation therapy - Pancreatic Cancer | Phase 2 | Completed | Benaroya Research Institute | 40 | 2008-09-01 | 2010-05-26 |
| Palliative Radiofrequency Ablation in Metastatic Renal Cell Carcinoma Patients Radiofrequency ablation; Interferon-alpha, Radiofrequency ablation; Sunitinib maleate, Sunitinib maleate - Carcinoma, Renal Cell | Phase 1 / Phase 2 | Completed | Kidney Cancer Research Bureau | 114 | 2008-05-01 | 2014-02-13 |
| Treatment of Oral Warts in HIV+ Patients Interferon-alpha, placebo - Papillomatosis, HIV Infections | Phase 2 | Completed | Ainos, Inc. (f/k/a Amarillo Biosciences Inc. | 59 | 2007-02-01 | 2011-09-16 |
| ABR-217620/Naptumomab Estafenatox With Interferon-alpha (IFN-alpha) Compared to IFN-alpha Alone in Patients With Advanced Renal Cell Carcinoma ABR-217620/naptumomab estafenatox, IFN-alpha - Renal Cell Carcinoma | Phase 2 / Phase 3 | Completed | Active Biotech AB | 526 | 2007-01-01 | 2015-07-22 |
| Capecitabine and Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients With Failure on Interleukin-2 Based Regimens capecitabine, interferon-alpha - Carcinoma, Renal Cell | Phase 2 | Completed | Kidney Cancer Research Bureau | 49 | 2006-12-01 | 2009-05-01 |
| Interferon and GM-CSF Compared With Imatinib Mesylate and Vaccine Therapy in Patients With Chronic Phase CML on a TKI GM-K562 cell vaccine, Interferon alfa, Sargramostim - Leukemia | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 36 | 2006-09-01 | 2018-11-13 |
| Safety Study of TroVax Alone vs. TroVax Plus Interferon Alpha in Patients With Renal Cancer TroVax® (Immunological Vaccine Therapy), Interferon-alpha - Carcinoma, Renal Cell | Phase 2 | Completed | The Methodist Hospital Research Institute | 28 | 2006-05-01 | 2016-03-17 |
| Interferon-Induced Gene Expression in Liver Cells and Peripheral Blood Lymphocytes Interferon alpha - Hepatitis C | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2 | 2006-05-01 | 2010-08-27 |
| Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease Veldona, - Behcet Syndrome, Behcet Disease | Phase 2 | Completed | Nobel Pharmaceuticals | 84 | 2006-04-01 | 2009-06-16 |
| Fludarabine and Radiation Therapy in Treating Patients Who Are Undergoing Donor Stem Cell Transplant for Chronic Phase or Accelerated Phase Chronic Myelogenous Leukemia recombinant interferon alfa, therapeutic allogeneic lymphocytes, cyclosporine - Leukemia | Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 2005-02-01 | 2011-11-17 |
| Interferon Alfa, Isotretinoin, and Paclitaxel in Treating Patients With Recurrent Small Cell Lung Cancer interferon alpha, 13-cis-retinoic acid, paclitaxel - Lung Cancer | Phase 2 | Completed | Eastern Cooperative Oncology Group | 37 | 2004-05-26 | 2023-07-07 |
| Granulocyte-macrophage Colony-stimulating Factor, Interferon and Interleukin-2 as Adjuvant Treatment for Renal Cancer GM-CSF, IFN alpha and IL-2 - Renal Cell Carcinoma | Phase 2 | Completed | Kidney Cancer Research Bureau | 35 | 2004-05-01 | 2010-08-24 |
| DC Vaccine Combined With IL-2 and IFNα-2a in Treating Patients With mRCC Aldesleukin,, autologous tumor cell vaccine, recombinant interferon alfa - Kidney Cancer | Phase 2 | Completed | Dartmouth-Hitchcock Medical Center | 18 | 2003-12-01 | 2018-06-26 |
| Oblimersen and Interferon Alfa in Treating Patients With Metastatic Renal Cell Cancer recombinant interferon alfa, oblimersen sodium, pharmacological study - Recurrent Renal Cell Cancer, Stage IV Renal Cell Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 41 | 2003-08-01 | 2013-08-26 |
| Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With HTLV-1-Related Adult T-Cell Leukemia/Lymphoma filgrastim, recombinant interferon alfa, Etoposide - Lymphoma | Phase 2 | Completed | AIDS Malignancy Consortium | 19 | 2002-10-01 | 2016-02-03 |
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Carcinoma, Renal Cell (15) · Leukemia (13) · Kidney Neoplasms (12) · Melanoma (12) · Leukemia, Myeloid, Chronic-Phase (11) · Lymphoma (9) · Multiple Myeloma (9) · Neoplasms, Plasma Cell (7) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (6) · Pancreatic Neoplasms (6) · Lymphoma, Follicular (5) · Burkitt Lymphoma (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Leukemia, Myeloid, Accelerated Phase (4) · Lung Neoplasms (4)
M.D. Anderson Cancer Center (6) · National Cancer Institute (NCI) (6) · Ainos, Inc. (f/k/a Amarillo Biosciences Inc. (4) · Eastern Cooperative Oncology Group (4) · Fred Hutchinson Cancer Center (4) · Hoag Memorial Hospital Presbyterian (4) · SWOG Cancer Research Network (4) · Kidney Cancer Research Bureau (3) · Memorial Sloan Kettering Cancer Center (3) · City of Hope Medical Center (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · St. Vincent Medical Center - Los Angeles (2) · University of New Mexico (2) · AIDS Malignancy Consortium (1) · Active Biotech AB (1)
United States (62) · Russia (4) · France (3) · Switzerland (3) · Canada (2) · Germany (2) · Italy (2) · Portugal (2) · Taiwan (2) · United Kingdom (2) · Australia (1) · Austria (1) · Belgium (1) · Bulgaria (1) · Hungary (1)
Robert O. Dillman, MD, FACP (4) · B. Douglas Smith, MD (2) · Charles L. Wiseman, MD, FACP (2) · Ilya V. Tsimafeyeu, MD (2) · Laura F. Hutchins, MD (2) · Leo I. Gordon, MD (2) · Scott Wadler, MD (2) · William Carson (2) · Aaron P. Rapoport, MD (1) · Ahmet Gul, MD (1) · Anastasios Raptis, MD (1) · Ayhan Dinc, MD (1) · Bin Chung, MD (1) · Brenda Sandmaier, MD (1) · Cem Mat, MD (1)
PMID 12074329, PMID 14508361, PMID 14581348, PMID 15308571, PMID 16170182, PMID 16249352, PMID 16260693, PMID 16706633, PMID 17023156, PMID 17366595, PMID 17443000, PMID 17932881, PMID 18162124, PMID 18645482, PMID 18650621, PMID 19204798, PMID 19228745, PMID 19622576, PMID 19717547, PMID 21163569, PMID 22021080, PMID 24237300, PMID 25669986, PMID 32499241, PMID 37146227, PMID 8368765
P30CA016672 (4), U10CA032102 (3), P30CA006973 (2), P30CA033572 (2), N01CM17101 (1), N01CM62207 (1), P30CA013330 (1), P30CA016058 (1), P30CA023108 (1), R01CA095648 (1), R21CA093071 (1), U01CA062505 (1), U01CA070019 (1), U01CA070172 (1), U10CA031946 (1)