15 completed, 4 unknown, 2 withdrawn, 1 not yet recruiting. 9 Phase 2, 6 Phase 3, 6 Phase 4, 3 Not applicable, 3 Phase 1.
Follow INH: new trials by email Literature Review of INH trials Research Report on INH
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of Age With and Without HIV Rifapentine, Isoniazid, Dolutegravir - Tuberculosis | Phase 1 / Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 144 | 2026-09-28 | 2026-11-02 |
| Short-Course Regimen With Bedaquiline, Moxifloxacin and Pyrazinamide for Early Bactericidal Activity in Drug-Susceptible Tuberculosis Bedaquiline (B), Moxifloxacin, Pyrazinamide (PZA) - Tuberculosis, Pulmonary, Drug-Susceptible Pulmonary Tuberculosis | Phase 2 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 45 | 2025-08-20 | 2025-08-19 |
| Trial of Novel Regimens for the Treatment of Pulmonary Tuberculosis Isoniazid, Rifampicin, Pyrazinamide - Pulmonary Tuberculosis | Phase 2 | Suspended | National Institute of Allergy and Infectious Diseases (NIAID) | 341 | 2025-03-11 | 2026-11-02 |
| 1HP Versus 3HR in the Treatment of Tuberculosis Infection in Vietnam Isoniazid, Rifapentine, Rifampicin - Tuberculosis Infection | Phase 3 | Withdrawn | Freundeskreis Für Internationale Tuberkulosehilfe e.V | 2024-11-01 | 2026-09-09 | |
| Phase I Open Label BCG Clinical Trial Assessing TB Drugs and Vaccines BCG Vaccine USP, Isoniazid, Rifampin - Tuberculosis | Phase 1 | Completed | Fred Hutchinson Cancer Center | 20 | 2022-12-06 | 2025-12-16 |
| Pharmacogenetics-guided Isoniazid Dosing in TB-HIV Isoniazid Tablets - Tuberculosis | Phase 2 | Unknown | Makerere University | 40 | 2021-12-07 | 2022-01-25 |
| Vaginal Dinoprostone Versus Isonicotinic Acid Hydrazide Prior to Diagnostic Office Hysteroscopy INH, dinoprostone - Postmenopausal Bleeding | Not applicable | Unknown | Aswan University Hospital | 200 | 2020-09-01 | 2021-09-29 |
| Vaginal Isonicotinic Acid Hydrazide Prior to Diagnostic Office Hysteroscopy in Primarily Infertile Patients INH, Placebo - Infertility, Female | Phase 4 | Completed | Aswan University Hospital | 150 | 2020-09-01 | 2021-09-29 |
| Vaginal Isonicotinic Acid Hydrazide (INH) Administration Prior to T380A Intrauterine Device Insertion INH, Placebo Comparator - IUCD Complication | Phase 4 | Completed | Aswan University Hospital | 220 | 2020-09-01 | 2021-08-09 |
| Vaginal Misoprostol and Dinoprostone and Isonicotinic Acid Hydrazide Prior to Copper Intrauterine Device Insertion Isonicotinic Acid Hydrazide, dinoprostine, misoprostol - IUCD Complication | Not applicable | Unknown | Aswan University Hospital | 200 | 2020-09-01 | 2020-08-18 |
| Vaginal Isonicotinic Acid Hydrazide Administration Prior to Intrauterine Device Insertion INH, Placebo Comparator - IUCD Complication | Phase 4 | Completed | Aswan University Hospital | 130 | 2020-09-01 | 2021-09-29 |
| Vaginal Isonicotinic Acid Hydrazide Administration Prior to Insertion Levonorgestrel-releasing Intrauterine System INH, Placebo Comparator - IUCD Complication | Phase 4 | Completed | Aswan University Hospital | 220 | 2020-08-01 | 2022-05-13 |
| Tuberculosis Clinical Trials Consortium Study 35 Rifapentine, Isoniazid - Latent Tuberculosis | Phase 1 / Phase 2 | Completed | Centers for Disease Control and Prevention | 69 | 2019-11-12 | 2026-07-24 |
| Building Evidence for Advancing New Treatment for Rifampicin Resistant Tuberculosis (RR-TB) Comparing a Short Course of Treatment (Containing Bedaquiline, Delamanid and Linezolid) With the Current South African Standard of Care Bedaquiline Oral Tablet, Linezolid Oral Tablet, Delamanid in Oral Dosage Form - Tuberculosis, Pre-XDR-TB | Phase 3 | Completed | Wits Health Consortium (Pty) Ltd | 402 | 2019-08-22 | 2024-08-28 |
| Video Based Directly Observed Therapy for Latent TB Rifapentine 600 mg orally, Isoniazid 900 mg orally, Pyridoxine 50 mg orally - Latent Tuberculosis | Withdrawn | St. Louis University | 2019-06-30 | 2019-07-01 | ||
| Alcohol Drinkers' Exposure to Preventive Therapy for TB (ADEPTT) Isoniazid 300 Mg ORAL TABLET, Pyridoxine 25 Mg Oral Tablet - Tuberculosis, HIV/AIDS | Phase 4 | Completed | University of California, San Francisco | 302 | 2017-04-07 | 2023-10-19 |
| Infant TB Infection Prevention Study Isoniazid - Tuberculosis | Phase 2 | Completed | University of Washington | 300 | 2016-08-01 | 2023-04-28 |
| An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis Linezolid, Bedaquiline, Levofloxacin - Tuberculosis, Multidrug Resistant Tuberculosis | Phase 2 / Phase 3 | Completed | University of Cape Town | 154 | 2015-11-12 | 2021-09-29 |
| Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention Weekly INH / RRT given by DOT - Silicosis, Tuberculosis | Phase 3 | Completed | Huashan Hospital | 566 | 2015-03-01 | 2020-06-30 |
| High-Dose Isoniazid Among Adult Patients With Different Genetic Variants of INH-Resistant Tuberculosis (TB) Isoniazid, Vitamin B6 - Tuberculosis | Phase 2 | Completed | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 282 | 2014-08-13 | 2023-02-17 |
Showing 20 of 25. Sign in to see all of them.
Tuberculosis (13) · Latent Tuberculosis (5) · Tuberculosis, Pulmonary (3) · Extensively Drug-Resistant Tuberculosis (2) · Tuberculosis, Multidrug-Resistant (2) · Acquired Immunodeficiency Syndrome (1) · Alcoholism (1) · HIV Infections (1) · Hepatitis (1) · Infertility, Female (1) · Silicosis (1)
Aswan University Hospital (6) · Centers for Disease Control and Prevention (4) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Fred Hutchinson Cancer Center (1) · Freundeskreis Für Internationale Tuberkulosehilfe e.V (1) · Huashan Hospital (1) · Makerere University (1) · National Taiwan University Hospital (1) · Shanghai Pulmonary Hospital, Shanghai, China (1) · St. Louis University (1) · University of California, San Francisco (1) · University of Cape Town (1) · University of Washington (1) · Wits Health Consortium (Pty) Ltd (1)
South Africa (7) · Egypt (6) · United States (5) · Brazil (4) · Haiti (4) · Kenya (4) · Uganda (4) · Spain (3) · Botswana (2) · Canada (2) · China (2) · Peru (2) · Thailand (2) · Vietnam (2) · Zimbabwe (2)
Kelly Dooley, MD, PhD (2) · Andreas H Diacon, MD, PhD (1) · Andrey S Borisov, MD, MPH (1) · Anneke Hesseling, MD (1) · Avy Violari, MD (1) · Christine Sekaggya-Wiltshire, MBChB, PhD (1) · Constance A Benson, MD (1) · Elsa M Villarino, MD, MPH (1) · Francesca M Conradie (1) · Grace John-Stewart, MD, PhD (1) · James Kublin, MD, MPH (1) · Jann-Yuan Wang (1) · Judith A Hahn, PhD, MA (1)
PMID 22150035, PMID 25904367, PMID 27243774, PMID 29393655, PMID 18419884, PMID 19656705, PMID 25580725, PMID 26260821, PMID 26951571, PMID 27010173, PMID 27268103, PMID 28087928, PMID 28406884, PMID 29114781, PMID 31690107, PMID 31770617, PMID 31932382, PMID 31945300, PMID 31969368, PMID 32553881, PMID 32564076, PMID 34042560, PMID 34403326, PMID 35175905, PMID 35315690, PMID 35607710, PMID 36044285, PMID 36808186, PMID 36815322, PMID 38564365, PMID 38640958, PMID 38768617, PMID 40195983, PMID 40320069, PMID 40817073, PMID 41504451, PMID 42341301
U01AI068636 (1), UM1AI068636 (1)