17 completed. 17 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 17 |
| Phase 1 | 1 | Completed 1 |
Follow Immunotherapy: new trials by email Literature Review of Immunotherapy trials Research Report on Immunotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients. Tislelizumab, Afatinib, Low dose radiotherapy - Head and Neck Squamous Cell Carcinoma, Low-dose Radiotherapy | Phase 2 | Completed | West China Hospital | 98 | 2025-06-28 | 2026-06-30 |
| Concurrent Radiotherapy Following Induction Chemoimmunotherapy for Locally Advanced Esophageal Cancer induction chemotherapy and immunotherapy - ESCC | Phase 2 | Completed | The First Affiliated Hospital with Nanjing Medical University | 44 | 2022-01-01 | 2025-06-11 |
| Molecular Profiling and Matched Targeted Therapy for Patients With Unresectable Advanced or Metastatic Melanoma Standard therapy or clinical trial, Matched targeted therapy, Trametinib and / or supportive care - Melanoma | Phase 2 | Completed | Melanoma Institute Australia | 216 | 2021-11-22 | 2026-05-29 |
| Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition Pembrolizumab (immunotherapy), Quad-shot palliative radiotherapy - Advanced Head and Neck Squamous Cell Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 2 | Completed | Wake Forest University Health Sciences | 21 | 2021-02-25 | 2025-11-19 |
| Neo-adjuvant Nivolumab or Nivolumab With Ipilimumab in Advanced Cutaneous Squamous Cell Carcinoma Prior to Surgery Nivolumab, Ipilimumab - Cutaneous Squamous Cell Carcinoma | Phase 2 | Completed | The Netherlands Cancer Institute | 50 | 2020-08-11 | 2025-08-11 |
| Cisplatin or ImmunoTHerapy in Association With Definitive Radiotherapy in HPV-related oropharyngEal Squamous Cell Carcinoma: a Randomized Phase II Trial. Chemoradiotherapy arm, Immunotherapy + Radiotherapy arm - Oropharyngeal Squamous Cell Carcinoma | Phase 2 | Completed | Institut Claudius Regaud | 11 | 2019-03-15 | 2025-08-08 |
| IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity IRX-2, Cyclophosphamide, Indomethacin - Squamous Cell Carcinoma of the Oral Cavity | Phase 2 | Completed | Brooklyn ImmunoTherapeutics, LLC | 105 | 2016-01-11 | 2024-01-30 |
| Safety Study of P28GST Treatment in Crohn's Disease Patients P28GST - Crohn's Ileocolitis | Phase 2 | Completed | University Hospital, Lille | 10 | 2014-03-01 | 2026-02-20 |
| Radiation Therapy and Intratumoral Autologous Dendritic Cells in Soft Tissue Sarcomas (STS) External Beam Radiation Therapy (RT), Autologous Dendritic Cells - Soft Tissue Sarcoma | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 20 | 2011-01-01 | 2016-05-23 |
| Efficacy and Tolerability of Two Different Administration Routes With SLITonePLUS Birch oral immunotherapy - Allergy | Phase 2 | Completed | ALK-Abelló A/S | 66 | 2010-01-01 | 2013-02-08 |
| Study With High Dose PURETHAL Mites in Allergic Rhinitis/Rhinoconjunctivitis Patients PURETHAL Mites 20,000 AUeq/ml - Allergic Rhinitis, Allergic Rhinoconjunctivitis | Phase 2 | Completed | HAL Allergy | 48 | 2009-08-01 | 2011-09-12 |
| Cetuximab Plus Conformal Thoracic Radiotherapy in Patients (Pts) With Inoperable or Unresectable Locally Advanced Non-Small Cell Lung Cancer (LA - NSCLC) Cetuximab, Conformal Thoracic Radiotherapy (CTRT) - Lung Cancer | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 27 | 2008-04-01 | 2015-10-08 |
| Immunotherapy With Depigmented and Polymerized Allergen Extract of Phleum Pratense Immunotherapy with modified extract of P. pratense pollen, Placebo - Rhinitis, Allergic, Seasonal, Conjunctivitis, Allergic | Phase 2 | Completed | Laboratorios Leti, S.L. | 80 | 2007-09-01 | 2010-12-17 |
| Universal Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)-Producing and CD40L Expressing Bystander Cell Line for Tumor Vaccine in Melanoma Bystander-Based Autologous Tumor Cell Vaccine - Melanoma (Skin) | Phase 2 | Completed | H. Lee Moffitt Cancer Center and Research Institute | 43 | 2004-10-01 | 2018-02-28 |
| HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies Chemotherapy and antibodies, Miltenyi Biotec CliniMACS, Allogeneic stem cell transplantation - Acute Myeloid Leukemia, Acute Lymphocytic Leukemia | Phase 2 | Completed | St. Jude Children's Research Hospital | 40 | 2004-05-01 | 2017-06-19 |
| Anti-pseudomonas IgY to Prevent Infections in Cystic Fibrosis Anti-pseudomonas IgY gargle - Cystic Fibrosis, Infection | Phase 1 / Phase 2 | Completed | Immunsystem AB | 14 | 2003-11-01 | 2016-09-01 |
| R-MegaCHOP-ESHAP-BEAM in Patients With High-Risk Aggressive B-Cell Lymphomas immunotherapy, Induction treatment part 1, Induction treatment part 2 with PBPC collection - Diffuse Large B-Cell Lymphoma., Primary Mediastinal B-Cell Lymphoma | Phase 2 | Completed | Czech Lymphoma Study Group | 106 | 2002-05-01 | 2007-11-14 |
Squamous Cell Carcinoma of Head and Neck (4) · Melanoma (2) · Anemia, Refractory, with Excess of Blasts (1) · Asthma (1) · Carcinoma, Non-Small-Cell Lung (1) · Conjunctivitis, Allergic (1) · Crohn Disease (1) · Cystic Fibrosis (1) · Head and Neck Neoplasms (1) · Histiocytosis (1) · Hypersensitivity (1) · Infections (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Leukemia, Myeloid, Acute (1) · Lung Neoplasms (1)
H. Lee Moffitt Cancer Center and Research Institute (3) · ALK-Abelló A/S (1) · Brooklyn ImmunoTherapeutics, LLC (1) · Czech Lymphoma Study Group (1) · HAL Allergy (1) · Immunsystem AB (1) · Institut Claudius Regaud (1) · Laboratorios Leti, S.L. (1) · Melanoma Institute Australia (1) · St. Jude Children's Research Hospital (1) · The First Affiliated Hospital with Nanjing Medical University (1) · The Netherlands Cancer Institute (1) · University Hospital, Lille (1) · Wake Forest University Health Sciences (1) · West China Hospital (1)
United States (6) · China (2) · France (2) · Germany (2) · Australia (1) · Brazil (1) · Canada (1) · Czechia (1) · Netherlands (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Alberto Chiappori, M.D. (2) · Alex Menzies (1) · Annika Hollsing, MD, PhD (1) · Brandon Triplett, MD (1) · Daniel Indelicato, M.D. (1) · Gregory T Wolf, MD, FACS (1) · Lotje Zuur, MD, PHD (1) · Mercedes Porosnicu, MD (1) · Pytlik Robert, M.D. (1) · Sophie Dessureault, M.D., Ph.D. (1) · Thomas Bieber, MD, PhD (1)
PMID 31212833, PMID 32671834, PMID 32738599, PMID 34376578, PMID 35135810, PMID 37199326, PMID 41062829, PMID 42313403
P30CA012197 (1)