8 completed, 1 active not recruiting, 1 withdrawn. 10 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 8, Active not recruiting 1, Withdrawn 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 1 | Withdrawn 1 |
Follow idebenone: new trials by email Literature Review of idebenone trials Research Report on idebenone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Oral Idebenone to Treat Non-Alcoholic Steatohepatitis Idebenone, Placebo - Non Alcoholic Steatohepatitis, Fibrosis | Phase 1 / Phase 2 | Completed | Stanford University | 53 | 2021-07-30 | 2026-04-24 |
| A Clinical Study of the Efficacy of Idebenone in the Treatment of iRBD Into Synucleinopathies Idebenone, Placebo - Rapid Eye Movement Sleep Behavior Disorder, Synucleinopathy | Phase 2 | Active not recruiting | Ruijin Hospital | 28 | 2020-08-31 | 2025-11-25 |
| A Study of Efficacy and Safety of Idebenone Vs. Placebo in Prodromal Parkinson Disease Idebenone, Placebo oral tablet - REM Sleep Behavior Disorder, Parkinson Disease | Phase 2 / Phase 3 | Withdrawn | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2020-01-01 | 2025-01-07 | |
| Idebenone for Primary Progressive Multiple Sclerosis Idebenone - Multiple Sclerosis, Primary Progressive Multiple Sclerosis | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 61 | 2013-03-12 | 2021-05-19 |
| Clinical Trial of Idebenone in Primary Progressive Multiple Sclerosis (IPPoMS) Idebenone, placebo - Primary Progressive Multiple Sclerosis | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 85 | 2009-11-01 | 2019-03-19 |
| Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes Idebenone, Placebo - MELAS Syndrome | Phase 2 | Completed | Michio Hirano | 27 | 2009-05-01 | 2016-10-26 |
| Long-term Safety, Tolerability and Efficacy of Idebenone in Duchenne Muscular Dystrophy (DELPHI Extension) Idebenone - Duchenne Muscular Dystrophy | Phase 2 | Completed | Santhera Pharmaceuticals | 21 | 2008-09-01 | 2011-06-01 |
| Study to Assess Efficacy,Safety and Tolerability of Idebenone in the Treatment of Leber's Hereditary Optic Neuropathy Idebenone, Placebo - Leber's Hereditary Optic Neuropathy | Phase 2 | Completed | Santhera Pharmaceuticals | 85 | 2007-11-01 | 2013-05-27 |
| Efficacy and Tolerability of Idebenone in Boys With Cardiac Dysfunction Associated With Duchenne Muscular Dystrophy idebenone, placebo - Duchenne Muscular Dystrophy (DMD) | Phase 2 | Completed | Santhera Pharmaceuticals | 21 | 2005-10-01 | 2011-08-01 |
| Idebenone to Treat Friedreich's Ataxia Idebenone - Friedreich Ataxia | Phase 2 | Completed | National Institute of Neurological Disorders and Stroke (NINDS) | 51 | 2005-09-27 | 2019-03-18 |
Multiple Sclerosis (2) · Multiple Sclerosis, Chronic Progressive (2) · Muscular Dystrophy, Duchenne (2) · REM Sleep Behavior Disorder (2) · Ataxia (1) · Fibrosis (1) · Friedreich Ataxia (1) · MELAS Syndrome (1) · Non-alcoholic Fatty Liver Disease (1) · Optic Atrophy, Hereditary, Leber (1) · Parkinson Disease (1) · Synucleinopathies (1)
Santhera Pharmaceuticals (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Michio Hirano (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · Ruijin Hospital (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Stanford University (1)
United States (5) · Belgium (2) · China (2) · Canada (1) · Germany (1) · United Kingdom (1)
Bibiana Bielekova, M.D. (2) · Baorong Zhang, MD (1) · Gunnar Buyse, MD PhD (1) · Kenneth H Fischbeck, M.D. (1) · Michio Hirano, MD (1) · Natalie Torok, MD (1) · Prof Gunnar Buyse, MD PhD (1) · Prof Patrick F Chinnery, MD (1) · Prof Thomas Klopstock, MD (1)
PMID 17826341, PMID 19847907, PMID 20090835, PMID 20599042, PMID 21435876, PMID 21788663, PMID 23263355, PMID 27574516, PMID 36172027
R21DK111217 (1)