7 completed, 1 terminated, 1 unknown. 4 Phase 2, 3 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 1, Terminated 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
Follow hypericin: new trials by email Literature Review of hypericin trials Research Report on hypericin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Confirmatory Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL Hypericin, Placebo - CTCL/ Mycosis Fungoides, CTCL | Phase 3 | Terminated | Soligenix | 70 | 2025-01-07 | 2026-07-13 |
| HyBryte (Synthetic Hypericin) Versus Valchlor (Mechlorethamine) in the Treatment of CTCL Hypericin, Mechlorethamine Topical Gel - Cutaneous T-Cell Lymphoma/Mycosis Fungoides | Phase 2 | Completed | Soligenix | 10 | 2023-12-05 | 2025-08-20 |
| Treatment of Mycosis Fungoides With Hypericin Ointment and Visible Light Hypericin, Visible Light - Cutaneous T Cell Lymphoma, Mycosis Fungoides | Phase 2 | Completed | Ellen Kim, MD | 10 | 2023-08-21 | 2026-02-09 |
| Topical SGX302 for Mild-to-Moderate Psoriasis Hypericin - Psoriasis, Plaque Psoriasis | Phase 2 | Completed | Soligenix | 15 | 2022-12-14 | 2026-08-13 |
| PK and ECG Determinations Following 8 Weeks of HyBryte Treatment for Cutaneous T-Cell Lymphoma Hypericin - Cutaneous T-Cell Lymphoma/Mycosis Fungoides | Phase 2 | Completed | Soligenix | 9 | 2022-05-09 | 2023-06-07 |
| FLASH [Fluorescent Light Activated Synthetic Hypericin] Clinical Study: Topical SGX301 (Synthetic Hypericin) for the Treatment of Cutaneous T-Cell Lymphoma (Mycosis Fungoides) SGX301 (synthetic hypericin), Placebo - Cutaneous T-Cell Lymphoma | Phase 3 | Completed | Soligenix | 169 | 2015-12-01 | 2022-04-15 |
| GAMALINE®+HIPERICIN® for PMS Treatment and Vasomotor Symptoms GAMALINE® + HIPERICIN®, GAMALINE® - Premenstrual Syndrome, Uterus; Hemorrhage, Preclimacteric or Premenopausal | Phase 3 | Unknown | Phytopharm Consulting Brazil | 240 | 2012-03-01 | 2011-12-06 |
| A Pharmacologically Guided Phase I/II Study of Daily Orally Administered Synthetic Hypericin in HIV-Infected Subjects Hypericin - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 24 | 2021-11-04 | |
| A Phase I Dose Escalation Study of Synthetic Hypericin in HIV-Infected Patients With Less Than 300 CD4 Lymphocytes Hypericin - HIV Infections | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 32 | 2021-11-03 |
Mycosis Fungoides (5) · Lymphoma, T-Cell, Cutaneous (3) · AIDS-Related Complex (2) · Acquired Immunodeficiency Syndrome (2) · HIV Infections (2) · Anxiety Disorders (1) · Depression (1) · Edema (1) · Hemorrhage (1) · Hot Flashes (1) · Premenstrual Syndrome (1) · Psoriasis (1)
Soligenix (5) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Ellen Kim, MD (1) · Phytopharm Consulting Brazil (1)
United States (8) · Brazil (1)
Valentine FT (2) · Carla Vanin, MD MSc PhD (1) · Crumpacker C (1)