7 completed, 1 recruiting, 1 terminated. 9 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 9 | Completed 7, Recruiting 1, Terminated 1 |
Follow Hydroxyurea: new trials by email Literature Review of Hydroxyurea trials Research Report on Hydroxyurea
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stroke Prevention in Nigeria 2 Trial Hydroxyurea - Sickle Cell Disease, Stroke | Phase 4 | Recruiting | Vanderbilt University Medical Center | 220 | 2024-08-05 | 2026-03-05 |
| Efficacy of Combination of Hdroxyurea and Thalidomide Over Hydroxyurea or Thalidomide in the Treatment of Transfusion Dependent Thalassemia in Children Thalidomide, Hydroxy Urea, Combinations - Transfusion-dependent Thalassemia | Phase 4 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 90 | 2023-11-01 | 2026-06-17 |
| Evaluation of HU-resistance in Adult Patients With Polycythemia Vera Who Meet PV-AIM Predictors Hydroxyurea - Polycythemia Vera | Phase 4 | Terminated | Novartis Pharmaceuticals | 76 | 2023-07-28 | 2026-08-18 |
| Hydoxycarbamide and L-Carnitine Therapy in Sickle Cell Anemia Hydroxycarbamide 500 Mg Oral Capsule+L-Carnitine, Hydroxycarbamide 500 Mg Oral Capsule, L-Carnitine, 250 Mg Oral Capsule - Sickle Cell Disease | Phase 4 | Completed | Assiut University | 91 | 2017-01-10 | 2021-10-22 |
| Evaluation of the Impact of Renal Function on the Pharmacokinetics of SIKLOS ® (DARH) Siklos - Sickle Cell Disease, Renal Function Disorder | Phase 4 | Completed | Theravia | 40 | 2015-09-03 | 2021-10-12 |
| Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment hydroxyurea - Sickle Cell Disease, Sickle Cell Anemia | Phase 4 | Completed | Loyola University | 53 | 2014-12-01 | 2023-03-09 |
| Future of Spermatogenesis in Men With Sickle Cell Disease Medically Treated Hydrea® (hydroxyurea ) - Drepanocytic Men Treated by Hydroxyurea for the First Time | Phase 4 | Completed | Assistance Publique - Hôpitaux de Paris | 50 | 2010-04-01 | 2013-08-07 |
| A Study of Anagrelide and Hydroxyurea in High-Risk Essential Thrombocythemia Patients Anagrelide, Hydroxyurea - Thrombocythemia, Hemorrhagic | Phase 4 | Completed | Shire | 150 | 2006-01-13 | 2021-06-02 |
| Safety and Effectiveness of a Combination Anti-HIV Drug Treatment Hydroxyurea, Abacavir sulfate, Efavirenz - HIV Infections | Phase 4 | Completed | Glaxo Wellcome | 150 | 1999-07-01 | 2005-06-24 |
Anemia, Sickle Cell (5) · HIV Infections (1) · Polycythemia Vera (1) · Stroke (1) · Thrombocythemia, Essential (1)
Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Glaxo Wellcome (1) · Loyola University (1) · Novartis Pharmaceuticals (1) · Shire (1) · Theravia (1) · Vanderbilt University Medical Center (1)
France (3) · Nigeria (2) · Bangladesh (1) · Bulgaria (1) · Egypt (1) · Germany (1) · Hungary (1) · Poland (1) · Portugal (1) · Serbia (1) · United States (1)
Bamidele O Tayo, PhD (1) · Israa EM Ashry, Prof (1) · Jacqueline Mandelbaum, Dr (1) · Lewis Hsu, MD (1) · Michael R DeBaun, MD, MPH (1) · Richard S Cooper, MD (1) · Titilola S Akingbola, MBBS, FWACP (1) · Victor R Gordeuk, MD (1)
PMID 29756251, PMID 30368038, PMID 30663794, PMID 33123978
2004 (1), U01NS129143 (1)