5 recruiting, 5 unknown, 4 completed, 3 active not recruiting. 25 Phase 2, 1 Phase 1, 1 Phase 3.
Follow HIPEC: new trials by email Literature Review of HIPEC trials Research Report on HIPEC
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heated Versus Aerosol-based Laparoscopic Chemotherapy for Cancer That Has Spread to the Peritoneum (Abdominal Lining) Heated intra-peritoneal chemotherapy, Aerosolized intra-peritoneal chemotherapy - Peritoneal (Metastatic) Cancer, Peritoneal Carcinomatosis | Phase 2 | Recruiting | Patrick Wagner, MD, FACS | 200 | 2026-01-05 | 2026-02-27 |
| A Prospective, Phase II Clinical Study of HIPEC Combined With NIPS and Tislelizumab Conversion Therapy for Gastric Cancer With Peritoneal Metastasis With Positive Cytology Alone or PCI Score ≤10 HIPEC, NIPS, Paclitaxel Injection, S-1, tislelizumab - Gastric Cancer Peritoneal Metastases | Phase 2 | Not yet recruiting | Hebei Medical University | 30 | 2025-12-12 | 2025-12-26 |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for Gastric Cancer at High Risk of Peritoneal Recurrence Biopsy Procedure, Biospecimen Collection, Cisplatin - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Enrolling by invitation | Mayo Clinic | 16 | 2025-12-03 | 2026-07-01 |
| A Clinical Study Evaluating the Efficacy of Systemic Chemotherapy and Immune Checkpoint Inhibitors Combined With Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer Patients With Peritoneal Metastasis HIPEC, SOX, Immune Checkpoint Inhibitors - Gastric Cancer | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 34 | 2025-02-15 | 2025-04-11 |
| The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM HIPEC, Systemic therapy - Gastric Cancer, Metastatic | Phase 2 | Active not recruiting | The First Affiliated Hospital with Nanjing Medical University | 50 | 2024-05-31 | 2025-07-16 |
| Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Nab-paclitaxel - Metastatic Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 2 | Active not recruiting | Mayo Clinic | 40 | 2024-02-15 | 2026-10-15 |
| Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study Cisplatin, Computed Tomography, Gastrectomy - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Recruiting | Mayo Clinic | 40 | 2023-04-20 | 2026-04-08 |
| HIPEC Combined Gastrectomy in Patients With Advanced Gastric Cancer Received Neoadjuvant Chemotherapy HIPEC - Gastric Cancer, Peritoneal Metastases | Phase 2 / Phase 3 | Not yet recruiting | Zhixin Cao | 200 | 2023-01-01 | 2022-12-06 |
| Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma Atezolizumab, Bevacizumab, Biospecimen Collection - Peritoneal Malignant Mesothelioma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2022-03-22 | 2026-11-12 |
| HIPEC-AS in Patients With Peritoneal Metastasis of the Stomach or Esophagogastric Junction HIPEC, Paclitaxel-albumin, Tegafur-gimeracil-oteracil potassium - Stomach Neoplasms, Peritoneal Metastases | Phase 2 | Not yet recruiting | Xuefei.Wang | 157 | 2021-10-01 | 2021-10-27 |
| Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial) HIPEC, intravenous chemotherapy - Hyperthermic Intraperitoneal Chemotherapy, Neoadjuvant Chemotherapy | Phase 2 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 80 | 2020-12-01 | 2022-02-18 |
| Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Locally Advanced Gastric Cancer D2 radical gastrectomy, SOX neoadjuvant or postoperative chemotherapy, Hyperthermic intraperitoneal chemotherapy (HIPEC) - Malignant Neoplasm of Stomach | Phase 2 | Unknown | Wuhan University | 100 | 2020-04-01 | 2020-04-14 |
| Heated Intraperitoneal Chemotherapy in Primary Ovarian Cancer Patients HIPEC, Carboplatin, Paclitaxel - Ovarian Cancer, Epithelial Ovarian Cancer | Phase 2 | Unknown | Andrea Jewell | 20 | 2017-12-15 | 2023-02-06 |
| HIPEC in Ovarian Carcinoma Clinical Stage IIIC and IV During Interval Laparotomy HIPEC - HPEC, Ovarian Cancer | Phase 2 | Recruiting | Instituto Nacional de Cancerologia de Mexico | 100 | 2017-09-02 | 2023-04-28 |
| Cytoreductive Surgery and Intraperitoneal Chemotherapy for Stomach CAncer: a Feasibility Study Perioperative chemotherapy, Cytoreduction, HIPEC - Gastric Cancer, Peritoneal Carcinomatosis | Phase 2 | Terminated | Richard van Hillegersberg | 3 | 2017-08-01 | 2019-04-17 |
| Heated Mitomycin and Cisplatin During Surgery in Treating Patients With Stomach or Gastroesophageal Cancer Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Mitomycin - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 24 | 2016-09-01 | 2024-09-19 |
| HIPEC After Secondary Cytoreductive Operation in Patients With Platinum-sensitive Recurrence of Ovarian Carcinoma HIPEC, Carboplatin - Epithelial Ovarian Cancer, Peritoneal Cancer | Phase 2 | Withdrawn | Krankenhaus Barmherzige Schwestern Linz | 2016-08-01 | 2020-03-04 | |
| HIPEC as Neoadjuvant Treatment for Resectable Pancreatic Adenocarcinoma Hyperthermic intraperitoneal chemotherapy, Open pancreaticoduodenectomy, Gemcitabine - Pancreatic Neoplasms, Pancreatic Adenocarcinoma | Phase 2 | Withdrawn | Wake Forest University Health Sciences | 2016-02-01 | 2022-04-27 | |
| HOT: HIPEC in Ovarian Cancer as Initial Treatment Cytoreductive Surgery (CRS), Adjuvant Chemotherapy, Questionnaire - Stage III Ovarian Cancer, Stage IV Ovarian Cancer | Phase 2 | Active not recruiting | Mercy Medical Center | 32 | 2014-04-01 | 2024-11-19 |
| HIPEC for Peritoneal Carcinomatosis HIPEC, Mitomycin C - Peritoneal Carcinomatosis, Colorectal Cancer | Phase 2 | Completed | Albert Einstein College of Medicine | 51 | 2011-11-01 | 2024-10-24 |
Showing 20 of 25. Sign in to see all of them.
Stomach Neoplasms (8) · Ovarian Neoplasms (6) · Peritoneal Neoplasms (6) · Fallopian Tube Neoplasms (5) · Carcinoma, Ovarian Epithelial (3) · Colorectal Neoplasms (3) · Neoplasm Metastasis (3) · Mesothelioma (2) · Pancreatic Neoplasms (2) · Appendiceal Neoplasms (1) · Gastrointestinal Neoplasms (1) · Neoplasms (1) · Peritoneal Diseases (1) · Pseudomyxoma Peritonei (1) · Recurrence (1)
Mayo Clinic (3) · Wuhan University (2) · Albert Einstein College of Medicine (1) · Andrea Jewell (1) · Bay Area Gynecology Oncology (1) · Catholic University of the Sacred Heart (1) · Hebei Medical University (1) · Instituto Nacional de Cancerologia de Mexico (1) · Jules Bordet Institute (1) · Krankenhaus Barmherzige Schwestern Linz (1) · M.D. Anderson Cancer Center (1) · Mercy Medical Center (1) · National Cancer Institute (NCI) (1) · Patrick Wagner, MD, FACS (1) · Richard van Hillegersberg (1)
United States (11) · China (6) · Austria (1) · Belgium (1) · Germany (1) · Mexico (1) · Netherlands (1)
Aaron S Mansfield (1) · Andrea Jewell, MD (1) · Anna Fagotti, MD, PhD (1) · Armando Sardi, M.D. (1) · Brian D Badgwell (1) · Cornelius A. Thiels, DO, MBA (1) · Dionisios Vrochides, MD PhD FACS (1) · Gabriella Ferrandina, MD (1) · Ida Paris, MD (1) · James Lilja, MD (1) · Jelle P Ruurda, MD PhD (1) · Jing Li, Doctor (1) · John McAuliffe, M.D. (1) · Joseph Kerger, M.D. (1)
PMID 24378877, PMID 27633880, PMID 30131226, PMID 32556731, PMID 37596449, PMID 37673112, PMID 37690994, PMID 40953882
2009 (1), 2015 (1), 2016 (1), U10CA180821 (1)