19 unknown, 12 completed, 8 active not recruiting, 8 recruiting. 25 Phase 2, 17 Phase 3, 8 Not applicable, 4 Phase 1, 3 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heated Versus Aerosol-based Laparoscopic Chemotherapy for Cancer That Has Spread to the Peritoneum (Abdominal Lining) Heated intra-peritoneal chemotherapy, Aerosolized intra-peritoneal chemotherapy - Peritoneal (Metastatic) Cancer, Peritoneal Carcinomatosis | Phase 2 | Recruiting | Patrick Wagner, MD, FACS | 200 | 2026-01-05 | 2026-02-27 |
| A Prospective, Phase II Clinical Study of HIPEC Combined With NIPS and Tislelizumab Conversion Therapy for Gastric Cancer With Peritoneal Metastasis With Positive Cytology Alone or PCI Score ≤10 HIPEC, NIPS, Paclitaxel Injection, S-1, tislelizumab - Gastric Cancer Peritoneal Metastases | Phase 2 | Not yet recruiting | Hebei Medical University | 30 | 2025-12-12 | 2025-12-26 |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin and Paclitaxel for Gastric Cancer at High Risk of Peritoneal Recurrence Biopsy Procedure, Biospecimen Collection, Cisplatin - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 | Phase 2 | Enrolling by invitation | Mayo Clinic | 16 | 2025-12-03 | 2026-07-01 |
| A Clinical Study Evaluating the Efficacy of Systemic Chemotherapy and Immune Checkpoint Inhibitors Combined With Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer Patients With Peritoneal Metastasis HIPEC, SOX, Immune Checkpoint Inhibitors - Gastric Cancer | Phase 2 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 34 | 2025-02-15 | 2025-04-11 |
| Study to Evaluate the Non-inferiority of Low-dose HIPEC Versus High-dose HIPEC in the Treatment of PMP (HIPEC-PMP) Mitomycin c - Pseudomyxoma Peritonei | Phase 3 | Recruiting | University of Southampton | 176 | 2024-12-04 | 2026-02-19 |
| A Prospective Cohort Study on the Treatment of Locally Advanced Gastric Cancer Tislelizumab, SOX, HIPEC - Gastric Cancer, Gastroesophageal Junction Cancer | Recruiting | Southwest Hospital, China | 122 | 2024-12-01 | 2025-01-07 | |
| The Efficacy and Safety of HIPEC Combined With PD-1 and SOX Chemotherapy for the Translational Treatment of GC or EGJC With PM HIPEC, Systemic therapy - Gastric Cancer, Metastatic | Phase 2 | Active not recruiting | The First Affiliated Hospital with Nanjing Medical University | 50 | 2024-05-31 | 2025-07-16 |
| Hyperthermic Intraperitoneal Chemotherapy for the Treatment of Pancreatic Cancer and Peritoneal Metastasis Cisplatin, Hyperthermic Intraperitoneal Chemotherapy, Nab-paclitaxel - Metastatic Pancreatic Carcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 2 | Active not recruiting | Mayo Clinic | 40 | 2024-02-15 | 2026-10-15 |
| Robotic Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Treatment of Gastric Cancer With Limited Peritoneal Metastasis, ROBO-CHIP Study Cisplatin, Computed Tomography, Gastrectomy - Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma | Phase 2 | Recruiting | Mayo Clinic | 40 | 2023-04-20 | 2026-04-08 |
| HIPEC Combined Gastrectomy in Patients With Advanced Gastric Cancer Received Neoadjuvant Chemotherapy HIPEC - Gastric Cancer, Peritoneal Metastases | Phase 2 / Phase 3 | Not yet recruiting | Zhixin Cao | 200 | 2023-01-01 | 2022-12-06 |
| Glycocalyx Monitoring in Major Abdominal Surgery Cytoreduction surgery with Hyperthermic Intraperitoneal Chemotherapy, Cephalic DuodenoPancreatectomy - Major Abdominal Surgery | Completed | University Hospital, Rouen | 78 | 2022-07-05 | 2026-05-22 | |
| Safety and Feasibility of HIPEC for High-Risk Gallbladder Adenocarcinoma HIPEC - Gallbladder Adenocarcinoma | Early Phase 1 | Recruiting | West Virginia University | 10 | 2022-06-23 | 2026-04-20 |
| Hyperthermic Intraperitoneal Chemotherapy With Cisplatin During Surgery or Cisplatin Before Surgery for the Treatment of Stage III or IV Ovarian, Fallopian Tube or Peritoneal Cancer Carboplatin, Cisplatin, Cytoreductive Surgery - Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma | Early Phase 1 | Active not recruiting | Ohio State University Comprehensive Cancer Center | 35 | 2022-06-13 | 2026-08-17 |
| CRS & HIPEC for Platinum-Resistant Recurrent Ovarian Cancer (KOV-02R, RECOVER) HIPEC - Epithelial Ovarian Cancer, Platinum Resistant | Phase 3 | Active not recruiting | National Cancer Center, Korea | 140 | 2022-04-07 | 2026-02-12 |
| The Efficacy of Hyperthermic Intraperitoneal Chemotherapy to Ovarian Cancer Patients With Homologous Recombination Repair Defect and Residual: a Prospective Cohort Study HIPEC - Ovarian Cancer | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 310 | 2022-04-01 | 2023-02-17 | |
| Chemotherapy With or Without Immunotherapy for Peritoneal Mesothelioma Atezolizumab, Bevacizumab, Biospecimen Collection - Peritoneal Malignant Mesothelioma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 66 | 2022-03-22 | 2026-10-26 |
| HIPEC-AS in Patients With Peritoneal Metastasis of the Stomach or Esophagogastric Junction HIPEC, Paclitaxel-albumin, Tegafur-gimeracil-oteracil potassium - Stomach Neoplasms, Peritoneal Metastases | Phase 2 | Not yet recruiting | Xuefei.Wang | 157 | 2021-10-01 | 2021-10-27 |
| Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial) HIPEC, intravenous chemotherapy - Hyperthermic Intraperitoneal Chemotherapy, Neoadjuvant Chemotherapy | Phase 2 | Unknown | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 80 | 2020-12-01 | 2022-02-18 |
| Raltitrexed in HIPEC Raltitrexed - Colorectal Cancer, Raltitrexed | Phase 1 | Completed | Fudan University | 30 | 2020-09-18 | 2026-02-25 |
| Conversion Therapy of Hyperthermic Intraperitoneal Chemotherapy Plus Chemotherapy and Chemotherapy in Stage IV Gastric Cancer Comparing Hyperthermic Intraperitoneal Chemotherapy, Paclitaxel, S1 - Gastric Cancer | Not applicable | Unknown | Tianjin Medical University Cancer Institute and Hospital | 180 | 2020-09-01 | 2022-02-08 |
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Stomach Neoplasms (19) · Ovarian Neoplasms (17) · Fallopian Tube Neoplasms (11) · Peritoneal Neoplasms (11) · Carcinoma, Ovarian Epithelial (9) · Colorectal Neoplasms (7) · Neoplasm Metastasis (3) · Appendiceal Neoplasms (2) · Mesothelioma (2) · Pancreatic Neoplasms (2) · Pseudomyxoma Peritonei (2) · Recurrence (2) · Uterine Cervical Neoplasms (2) · Uterine Neoplasms (2) · Carcinoma (1)
Affiliated Cancer Hospital & Institute of Guangzhou Medical University (4) · Mayo Clinic (4) · Wuhan University (4) · Loma Linda University (2) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2) · Ajou University School of Medicine (1) · Albert Einstein College of Medicine (1) · Andrea Jewell (1) · Bay Area Gynecology Oncology (1) · Cantonal Hospital of St. Gallen (1) · Catholic University of the Sacred Heart (1) · Centre Oscar Lambret (1) · Charite University, Berlin, Germany (1) · Fudan University (1) · Hebei Medical University (1)
China (22) · United States (19) · Belgium (3) · France (3) · Germany (2) · Netherlands (2) · South Korea (2) · Spain (2) · Austria (1) · Mexico (1) · Singapore (1) · Switzerland (1) · United Kingdom (1)
Shuzhong Cui, M.D (2) · Zhongqiu Lin, M.D (2) · Aaron S Mansfield (1) · Andrea Jewell, MD (1) · Anna Fagotti, MD, PhD (1) · Armando Sardi, M.D. (1) · Beate Rau, Prof. (1) · Brian Boone, MD (1) · Brian D Badgwell (1) · Cornelius A. Thiels, DO, MBA (1) · Dionisios Vrochides, MD PhD FACS (1) · Douglas S Scherr, MD (1) · Faheez Mohamed, MBChB, MD, FRCS (1) · Floor Backes, MD (1)
PMID 16394300, PMID 16485159, PMID 21448361, PMID 24378877, PMID 26811651, PMID 26903580, PMID 27633880, PMID 27650694, PMID 30131226, PMID 31060544, PMID 32556731, PMID 32696309, PMID 35100917, PMID 37596449, PMID 37673112, PMID 37690994, PMID 37906724, PMID 37916797, PMID 39549720, PMID 39955184, PMID 40953882, PMID 42419336
2015 (2), 2009 (1), 2016 (1), 2018 (1), U10CA180821 (1)