8 completed, 3 terminated, 1 not yet recruiting, 1 unknown. 10 Not applicable, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 7, Terminated 2, Not yet recruiting 1 |
| Early Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Health Maintenance Organizations: new trials by email Literature Review of Health Maintenance Organizations trials Research Report on Health Maintenance Organizations
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Milk Free From A1-Type β-Casein With Human Milk Oligosaccharides on Gut Health, Immunity, Cognitive Development, and Temperament in Toddlers a2 toddler milk with HMOs, Conventional toddler milk with HMOs - Healthy Volunteers | Not applicable | Not yet recruiting | a2 Milk Company Ltd. | 80 | 2026-11-01 | 2026-10-20 |
| Study To Evaluate The Safety And Efficacy of PBCLN-010 In Combination With PBCLN-014 in Participants Receiving Allogeneic Hematopoietic Cell Transplantation B. infantis (PBCLN-014) and Human Milk Oligosaccharides (HMO) (PBCLN-010) - Hematologic Malignancy | Phase 2 | Terminated | Prolacta Bioscience | 46 | 2023-09-18 | 2024-08-19 |
| Human Milk Oligosaccharide (HMO) Supplementation in Colic Management HMO, Placebo, Parental reassurance and support - Colic | Not applicable | Terminated | Société des Produits Nestlé (SPN) | 5 | 2022-06-24 | 2024-06-14 |
| Prebiotic Therapy to Improve Outcomes of Renal Transplant Human Milk Oligosaccharides (HMO), Placebo - Kidney Transplant; Complications | Early Phase 1 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 60 | 2022-02-23 | 2023-11-01 |
| Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction Human Milk Oligosaccharides (HMO), Placebo - Spinal Cord Injuries, Neurogenic Bowel | Phase 3 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 30 | 2021-01-27 | 2023-12-13 |
| Iron Absorption From an Iron-fortified Follow-up Formula With Added Synbiotic or Human Milk Oligosaccharides Test formula A without added pre- and pro-biotic, Test formula B with synbiotic, Test formula C with HMOs - Iron Absorption | Not applicable | Completed | Société des Produits Nestlé (SPN) | 82 | 2020-11-18 | 2023-03-24 |
| Growth and Safety of Two Partially-hydrolyzed Feeding Systems for Preterm Infants Preterm formulas with HMO, Preterm formulas without HMO - Pre-term Infant | Not applicable | Completed | Société des Produits Nestlé (SPN) | 28 | 2020-09-10 | 2026-01-16 |
| The Effect of Human Milk Oligosaccharides and Galacto-oligosaccharides on Iron Absorption in Kenyan Infants ferrous fumarate, ferrous fumarate + GOS, ferrous fumarate + HMOs - Anemia, Iron-deficiency | Not applicable | Completed | Swiss Federal Institute of Technology | 55 | 2019-11-21 | 2022-06-23 |
| Growth and Tolerance Trial on Infant Formula With HMO Standard infant formula, Infant formula supplemented with HMO - Healthy Growth | Not applicable | Terminated | FrieslandCampina | 265 | 2019-09-23 | 2023-09-28 |
| Clinical Safety & Efficacy of a New Infant Formula With Specific Medical Purpose Containing Human Milk Oligosaccharides Test infant formula with HMOs, Control infant formula without HMOs - Cow's Milk Protein Allergy | Not applicable | Completed | Société des Produits Nestlé (SPN) | 194 | 2017-02-22 | 2019-07-23 |
| Human Milk Oligosaccharides and Childhood Diarrhoea Oral rehydration solution, Zinc, Human milk oligosaccharides - Acute Diarrhea | Not applicable | Completed | Société des Produits Nestlé (SPN) | 435 | 2016-06-01 | 2019-07-23 |
| Effects of HMOs on the Faecal Microbiota and on Host Metabolism in Obese Children HMO, Dextropur - Obesity | Not applicable | Completed | Glycom A/S | 75 | 2016-05-01 | 2018-12-13 |
| The Effects Of HMO On The Faecal Microbiota And On Gastrointestinal Symptoms In Healthy Volunteers HMO, Glucose - Gut Microbiota, Gastrointestinal Symptoms | Not applicable | Completed | Glycom A/S | 100 | 2014-05-01 | 2015-03-18 |
Anemia (1) · Anemia, Iron-Deficiency (1) · Colic (1) · Diarrhea (1) · Hematologic Neoplasms (1) · Milk Hypersensitivity (1) · Neurogenic Bowel (1) · Obesity (1) · Spinal Cord Injuries (1)
Société des Produits Nestlé (SPN) (5) · Glycom A/S (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · FrieslandCampina (1) · Prolacta Bioscience (1) · Swiss Federal Institute of Technology (1) · a2 Milk Company Ltd. (1)
Canada (2) · Denmark (2) · Italy (2) · Poland (2) · Spain (2) · United States (2) · Bangladesh (1) · Belgium (1) · China (1) · Germany (1) · Hungary (1) · Kenya (1) · Singapore (1) · Slovakia (1) · Thailand (1)
Alp Sener, MD (1) · Jens-Christian Holm, MD, PhD (1) · Jeremy P Burton, PhD (1) · Maryam Olesen (1) · Michael B Zimmermann, Prof. Dr. (1) · Peter Bytzer, MD (1)
PMID 15541456, PMID 24643131, PMID 29270002, PMID 30586752, PMID 34139746, PMID 36126902, PMID 36789945, PMID 39179207