8 completed, 7 unknown, 2 active not recruiting, 2 recruiting. 21 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Completed 8, Unknown 7, Active not recruiting 2, Recruiting 2, Terminated 1, Withdrawn 1 |
Follow FOLFOXIRI protocol: new trials by email Literature Review of FOLFOXIRI protocol trials Research Report on FOLFOXIRI protocol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modified FOLFOXIRI Plus Target Therapy as a First Line Treatment for Advanced Colorectal Cancer a Prospective Phase Two Study FOLFOXIRI Protocol - Neoplasm Malignant, Colon Cancer Stage 4 | Phase 2 | Unknown | Al-Azhar University | 60 | 2024-08-17 | 2024-08-28 |
| CtDNA in Adjuvant Chemotherapy of Stage III Colon Cancer (REVISE Trial) FOLFOXIRI, XELOX - Colon Cancer | Phase 2 | Recruiting | West China Hospital | 60 | 2024-03-25 | 2024-12-12 |
| Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II-III FOLFOXIRI, CAPOX - Colorectal Neoplasms Malignant, Minimal Residual Disease | Phase 2 | Active not recruiting | Fundación para la Investigación del Hospital Clínico de Valencia | 45 | 2022-01-01 | 2026-09-15 |
| Induction Chemotherapy for Locally Advanced Rectal Cancer FOLFOXIRI Protocol - Rectal Cancer | Phase 2 | Active not recruiting | Catharina Ziekenhuis Eindhoven | 128 | 2021-11-03 | 2026-10-23 |
| FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases Cetuximab, Bevacizumab, FOLFOXIRI - Liver Metastasis Colon Cancer | Phase 2 | Unknown | Fudan University | 160 | 2021-04-17 | 2021-04-06 |
| Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primary FOLFOXIRI Protocol, Cisplatin injection - Neuroendocrine Carcinoma | Phase 2 | Recruiting | Centre Hospitalier Universitaire Dijon | 218 | 2020-09-01 | 2025-09-30 |
| Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer FOLFOXIRI, FOLFOX regimen, XELOX - Rectal Cancer | Phase 2 | Completed | Stanford University | 38 | 2020-05-21 | 2025-02-25 |
| Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer FOLFOXIRI - Colorectal Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-05-01 | 2021-04-19 |
| Neoadjuvant FOLFOXIRI Chemotherapy in Patients With Locally Advanced Colon Cancer FOLFOXIRI - Colonic Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-04-01 | 2021-04-19 |
| Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer FOLFOXIRI, Short-Course Radiation Therapy(5Gy*5), XELOX - Rectal Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-04-01 | 2021-04-14 |
| Triplet (FOLFOXIRI) vs. Doublet (FOLFOX or FOLFIRI) Regimen as a 1st Line Treatment in Metastatic Colorectal Carcinoma FOLFOXIRI Protocol - Metastatic Colorectal Cancer | Phase 2 | Completed | Kasr El Aini Hospital | 64 | 2018-01-16 | 2022-04-07 |
| FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin (CRM) Positive Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Withdrawn | Guangxi Medical University | 2017-08-11 | 2019-08-08 | |
| Chemotherapy Intensification in Patients With High Lactate Dehydrogenase Values and Soluble Syndecan1 Levels FOLFOXIRI, FOLFOX, FOLFIRI - Metastatic Colorectal Cancer | Phase 2 | Terminated | Centre Hospitalier Universitaire de Besancon | 54 | 2017-08-04 | 2025-02-05 |
| Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Unknown | RenJi Hospital | 100 | 2016-11-01 | 2018-01-03 |
| Neoadjuvant Triplet Chemotherapy Regimen in Patients With Locally Advanced Rectal Cancer FOLFOXIRI - Locally Advanced Rectal Cancer | Phase 2 | Completed | Aiping Zhou | 50 | 2016-02-06 | 2021-02-01 |
| FOLFOXIRI With or Without Bevacizumab as First-line Treatment for Unresectable Liver-only Metastatic Colorectal Cancer Patients With RAS Mutation-type FOLFOXIRI + Bevacizumab, FOLFOXIRI - Metastatic Colorectal Cancer | Phase 2 | Completed | Sun Yat-sen University | 138 | 2015-01-01 | 2026-05-22 |
| Neoadjuvant FOLFOXIRI Chemotherapy Alone for Locally Advanced Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Completed | Sun Yat-sen University | 100 | 2014-08-15 | 2021-04-14 |
| FOLFOXIRI Compared to FOLFOX in First Line Treatment of Metastatic Colorectal Cancer FOLFOXIRI, FOLFOX - Metastatic Colorectal Cancer | Phase 2 | Unknown | Sun Yat-sen University | 162 | 2014-04-01 | 2014-05-07 |
| FOLFOXIRI With or Without Cetuximab as First-line Treatment of Patients With Non-resectable Liver - Only Metastatic Colorectal Cancer FOLFOXIRI + Cetuximab, FOLFOXIRI - Metastatic Colorectal Cancer | Phase 2 | Completed | Sun Yat-sen University | 101 | 2014-02-01 | 2020-03-31 |
| FOLFOXIRI as Primary Treatment for Locally Advanced Pancreatic Cancer FOLFOXIRI - Pancreatic Carcinoma Stage III | Phase 2 | Completed | Azienda Ospedaliero, Universitaria Pisana | 50 | 2012-12-01 | 2015-01-30 |
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Colorectal Neoplasms (7) · Rectal Neoplasms (7) · Colonic Neoplasms (4) · Carcinoma, Neuroendocrine (1) · Neoplasm, Residual (1) · Neoplasms (1) · Neoplastic Cells, Circulating (1) · Pancreatic Neoplasms (1)
Sun Yat-sen University (4) · China Medical University, China (3) · AIO-Studien-gGmbH (1) · Aiping Zhou (1) · Al-Azhar University (1) · Azienda Ospedaliero, Universitaria Pisana (1) · Catharina Ziekenhuis Eindhoven (1) · Centre Hospitalier Universitaire Dijon (1) · Centre Hospitalier Universitaire de Besancon (1) · Fudan University (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · Guangxi Medical University (1) · Kasr El Aini Hospital (1) · RenJi Hospital (1) · Stanford University (1)
China (12) · Egypt (2) · France (2) · Germany (1) · Italy (1) · Netherlands (1) · Spain (1) · United States (1)
Yanhong Deng, M.D. (3) · Jingdong Zhang (2) · Aiping Zhou, Doctor (1) · Erqi L Pollom (1) · Jacobus W.A. Burger, MD. PhD. (1) · Ming Ye, Master (1) · Wen Zhang (1) · Yuzhou Qin (1)
PMID 10744089, PMID 11247898, PMID 15175435, PMID 15870084, PMID 16943526, PMID 17470860, PMID 18316791, PMID 19097774, PMID 19339720, PMID 19755046, PMID 21090969, PMID 24138831, PMID 26818619, PMID 31609637, PMID 35834598, PMID 36068495, PMID 37370032, PMID 38902952, PMID 39753246, PMID 42743885
2009 (1)