10 completed, 9 unknown, 5 recruiting, 2 active not recruiting. 21 Phase 2, 7 Phase 3, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neoadjuvant FOLFOXIRI and Chemoradiotherapy Versus Neoadjuvant CAPOX/FOLFOX and Chemoradiotherapy Followed by Surgery or a Watch-and-Wait Approach in High Risk Locally Advanced Rectal Cancer FOLFOXIRI, CAPOX, FOLFOX (5-fluorouracil, Leucovorin, Oxaliplatin) - Locally Advanced Rectal Carcinoma | Phase 3 | Recruiting | J. W. A. Burger | 394 | 2026-03-16 | 2026-10-23 |
| Modified FOLFOXIRI Plus Target Therapy as a First Line Treatment for Advanced Colorectal Cancer a Prospective Phase Two Study FOLFOXIRI Protocol - Neoplasm Malignant, Colon Cancer Stage 4 | Phase 2 | Unknown | Al-Azhar University | 60 | 2024-08-17 | 2024-08-28 |
| CtDNA in Adjuvant Chemotherapy of Stage III Colon Cancer (REVISE Trial) FOLFOXIRI, XELOX - Colon Cancer | Phase 2 | Recruiting | West China Hospital | 60 | 2024-03-25 | 2024-12-12 |
| Circulating Tumor DNA Based Decision for Adjuvant Treatment in Colon Cancer Stage II-III FOLFOXIRI, CAPOX - Colorectal Neoplasms Malignant, Minimal Residual Disease | Phase 2 | Active not recruiting | Fundación para la Investigación del Hospital Clínico de Valencia | 45 | 2022-01-01 | 2026-09-15 |
| Induction Chemotherapy for Locally Advanced Rectal Cancer FOLFOXIRI Protocol - Rectal Cancer | Phase 2 | Active not recruiting | Catharina Ziekenhuis Eindhoven | 128 | 2021-11-03 | 2026-10-23 |
| Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer FOLFOXIRI, CapeOX - Rectal Cancer | Phase 3 | Recruiting | Fudan University | 300 | 2021-08-27 | 2022-03-04 |
| FOLFOXIRI Plus Cetuximab Versus FOLFOXIRI Plus Bevacizumab in Conversion Therapy of Right-sided Colon Cancer Liver Metastases Cetuximab, Bevacizumab, FOLFOXIRI - Liver Metastasis Colon Cancer | Phase 2 | Unknown | Fudan University | 160 | 2021-04-17 | 2021-04-06 |
| Chemotherapy For Metastatic Grade 3 Poorly Differentiated NEuroendocrine Carcinoma Of GastroEnteroPancreatic And Unknown Primary FOLFOXIRI Protocol, Cisplatin injection - Neuroendocrine Carcinoma | Phase 2 | Recruiting | Centre Hospitalier Universitaire Dijon | 218 | 2020-09-01 | 2025-09-30 |
| Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer FOLFOXIRI, FOLFOX regimen, XELOX - Rectal Cancer | Phase 2 | Completed | Stanford University | 38 | 2020-05-21 | 2025-02-25 |
| Brazilian Total Neoadjuvant Therapy Trial Folfirinox - Colorectal Neoplasms | Phase 3 | Unknown | Hospital Israelita Albert Einstein | 150 | 2020-02-20 | 2023-10-11 |
| Triplet Combination or Doublet Regimen Versus Chemoradiation as Neoadjuvant Therapy for Locally Advanced Rectal Cancer Chemoradiation, FOLFOXIRI Protocol, Folfox Protocol - Rectal Cancer, Chemotherapy Effect | Phase 3 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 933 | 2019-08-01 | 2019-06-05 |
| Prospectively Randomized Control Clinical Trial of FOLFOXIRI Preoperative Chemotherapy Alone on Rectal Cancer in Local Advance Comparing to Oral Capecitabine Combined With Long-term Radiation FOLFOXIRI, XELOX, Chemoradiotherapy - Rectal Cancer | Phase 3 | Recruiting | Sun Yat-sen University | 776 | 2018-11-16 | 2019-01-23 |
| Neoadjuvant FOLFOXIRI Chemotherapy in Resectable Liver Metastasis of Colorectal Cancer FOLFOXIRI - Colorectal Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-05-01 | 2021-04-19 |
| Neoadjuvant FOLFOXIRI Chemotherapy in Patients With Locally Advanced Colon Cancer FOLFOXIRI - Colonic Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-04-01 | 2021-04-19 |
| Totally Neoadjuvant FOLFOXIRI + Short-course Radiation + XELOX in Patients With Locally Advanced Rectal Cancer FOLFOXIRI, Short-Course Radiation Therapy(5Gy*5), XELOX - Rectal Neoplasms, Drug Therapy | Phase 2 | Unknown | China Medical University, China | 30 | 2018-04-01 | 2021-04-14 |
| Triplet (FOLFOXIRI) vs. Doublet (FOLFOX or FOLFIRI) Regimen as a 1st Line Treatment in Metastatic Colorectal Carcinoma FOLFOXIRI Protocol - Metastatic Colorectal Cancer | Phase 2 | Completed | Kasr El Aini Hospital | 64 | 2018-01-16 | 2022-04-07 |
| FOLFOXIRI Chemotherapy Alone as Neoadjuvant Treatment for Circumferential Radial Margin (CRM) Positive Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Withdrawn | Guangxi Medical University | 2017-08-11 | 2019-08-08 | |
| Chemotherapy Intensification in Patients With High Lactate Dehydrogenase Values and Soluble Syndecan1 Levels FOLFOXIRI, FOLFOX, FOLFIRI - Metastatic Colorectal Cancer | Phase 2 | Terminated | Centre Hospitalier Universitaire de Besancon | 54 | 2017-08-04 | 2025-02-05 |
| Research on the Treatment of Metastatic Colon Cancer Patients Treated by FOLFOXIRI FOLFOXIRI - Colorectal Cancer | Completed | Hanoi Medical University | 39 | 2017-01-01 | 2018-04-20 | |
| Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer FOLFOXIRI - Rectal Cancer | Phase 2 | Unknown | RenJi Hospital | 100 | 2016-11-01 | 2018-01-03 |
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Rectal Neoplasms (11) · Colorectal Neoplasms (10) · Colonic Neoplasms (5) · Pancreatic Neoplasms (2) · Carcinoma, Neuroendocrine (1) · Neoplasm Metastasis (1) · Neoplasm, Residual (1) · Neoplasms (1) · Neoplastic Cells, Circulating (1) · Pathologic Complete Response (1)
Sun Yat-sen University (5) · China Medical University, China (3) · Azienda Ospedaliero, Universitaria Pisana (2) · Fudan University (2) · AIO-Studien-gGmbH (1) · Aiping Zhou (1) · Al-Azhar University (1) · Catharina Ziekenhuis Eindhoven (1) · Centre Hospitalier Universitaire Dijon (1) · Centre Hospitalier Universitaire de Besancon (1) · Fundación para la Investigación del Hospital Clínico de Valencia (1) · Gruppo Oncologico del Nord-Ovest (1) · Guangxi Medical University (1) · Hanoi Medical University (1) · Hospital Israelita Albert Einstein (1)
China (14) · Italy (3) · Egypt (2) · France (2) · Netherlands (2) · Spain (2) · Brazil (1) · Germany (1) · United States (1) · Vietnam (1)
Yanhong Deng, M.D. (3) · Jingdong Zhang (2) · Aiping Zhou, Doctor (1) · Alfredo Falcone, MD (1) · Carlos Moreno Sanz (1) · Diogo Gomes, MD (1) · Eduardo Targarona Soler (1) · Enrico Vasile, MD, PhD (1) · Erqi L Pollom (1)
PMID 10744089, PMID 11247898, PMID 15175435, PMID 15870084, PMID 16943526, PMID 17470860, PMID 18316791, PMID 19097774, PMID 19339720, PMID 19755046, PMID 21090969, PMID 24138831, PMID 26818619, PMID 26861604, PMID 28497402, PMID 31609637, PMID 35834598, PMID 36068495, PMID 37370032, PMID 38412408, PMID 38902952, PMID 39753246, PMID 42151882, PMID 42743885
2009 (1), 2025 (1)