20 completed, 4 active not recruiting, 3 terminated, 2 unknown. 30 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 30 | Completed 20, Active not recruiting 4, Terminated 3, Unknown 2, Recruiting 1 |
| Phase 2 | 3 | Active not recruiting 2, Completed 1 |
Follow Flutamide: new trials by email Literature Review of Flutamide trials Research Report on Flutamide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial Bicalutamide, Buserelin, Darolutamide - Prostate Adenocarcinoma | Phase 3 | Active not recruiting | NRG Oncology | 2050 | 2021-12-06 | 2026-08-17 |
| Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer PET-directed Local Therapy using Surgery, PET-directed Local Therapy using Radiation, Salvage Local Therapy for locally recurrent disease - Prostate Cancer, Oligometastasis | Phase 2 / Phase 3 | Active not recruiting | VA Office of Research and Development | 378 | 2021-07-01 | 2026-10-19 |
| Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial Apalutamide, Bicalutamide, Biospecimen Collection - Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 | Phase 3 | Active not recruiting | NRG Oncology | 2753 | 2021-01-21 | 2026-08-17 |
| Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer Abiraterone, Bicalutamide, Degarelix - Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 1273 | 2018-09-24 | 2026-10-08 |
| Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery Bicalutamide, Degarelix, Docetaxel - Stage I Prostate Adenocarcinoma AJCC v7, Stage II Prostate Adenocarcinoma AJCC v7 | Phase 2 / Phase 3 | Active not recruiting | NRG Oncology | 612 | 2017-04-05 | 2026-09-14 |
| Hormone Therapy, Radiation Therapy, and Steroid 17alpha-monooxygenase TAK-700 in Treating Patients With High-Risk Prostate Cancer GnRH agonist, Anti-androgen, TAK-700 - Prostate Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 239 | 2012-05-01 | 2026-03-06 |
| Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer bicalutamide, flutamide, LHRH agonist (antagonist) therapy - Prostate Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 1538 | 2009-09-01 | 2026-03-06 |
| Androgen Suppression and Radiation With/Out Docetaxel in High-Risk Localized Prostate Cancer bicalutamide, buserelin, flutamide - Prostate Cancer | Phase 3 | Terminated | NCIC Clinical Trials Group | 48 | 2008-06-02 | 2023-08-04 |
| Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer PBRT, PLNRT, AA - Prostate Cancer | Phase 3 | Unknown | Radiation Therapy Oncology Group | 1792 | 2008-02-01 | 2025-05-09 |
| External Beam Radiation Therapy (EBRT) With or Without Hormonal Therapy in Prostate Cancer Radiation Therapy, Bicalutamide, Leuprolide - Prostate Cancer | Phase 3 | Terminated | M.D. Anderson Cancer Center | 39 | 2005-02-01 | 2012-08-08 |
| Treatment of Hot Flushes Caused by Leuprorelin 11.25 mg in Prostate Adenocarcinoma Cyproterone acetate, Medroxyprogesterone acetate, Venlafaxine - Adenocarcinoma, Prostate | Phase 3 | Completed | Takeda | 311 | 2004-04-01 | 2015-07-30 |
| Finasteride and Flutamide in Pre-surgical Trial in Prostate Cancer. Flutamide, Finasteride, Placebo - Prostate Cancer, Prostatic Intraepithelial Neoplasia | Phase 2 / Phase 3 | Completed | Ente Ospedaliero Ospedali Galliera | 125 | 2004-01-01 | 2024-09-19 |
| Triptorelin, Flutamide, and External-Beam Radiation Therapy or External-Beam Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer flutamide, triptorelin, radiation therapy - Prostate Cancer | Phase 3 | Completed | UNICANCER | 378 | 2003-09-10 | 2021-02-21 |
| Hormone Therapy Plus Chemotherapy in Treating Patients With Prostate Cancer bicalutamide, docetaxel, doxorubicin hydrochloride - Prostate Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 21 | 2002-10-01 | 2020-10-22 |
| Adjuvant Radiation Therapy Plus Hormone Therapy Compared With Radiation Therapy Alone in Treating Patients With Stage II or Stage III Prostate Cancer bicalutamide, flutamide, releasing hormone agonist therapy - Prostate Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 67 | 2001-08-01 | 2020-10-22 |
| Leuprorelin Associated With Radiotherapy Versus Leuprorelin Alone in T3 - T4 or pT3 (on Biopsy) N0, M0 Prostate Cancer Leuprorelin SR, Radiotherapy, Flutamide - Prostatic Neoplasms, Locally Advanced | Phase 3 | Completed | Takeda | 273 | 2000-03-01 | 2015-07-29 |
| Hormone Therapy and Radiation Therapy in Treating Patients With Prostate Cancer Casodex, Eulexin, LHRH agonist - Prostate Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 1579 | 2000-02-01 | 2022-06-15 |
| Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer bicalutamide, estramustine phosphate sodium, etoposide - Prostate Cancer | Phase 3 | Completed | Radiation Therapy Oncology Group | 397 | 2000-01-01 | 2020-10-22 |
| Randomized Trial of Adjuvant Hormonal Therapy in Surgically Treated Prostate Cancer Patients at High Risk for Recurrence Flutamide, Leuprolide Acetate - Prostate Cancer | Phase 3 | Terminated | M.D. Anderson Cancer Center | 64 | 1999-06-14 | 2020-04-28 |
| Hormone Therapy in Treating Patients With Rising PSA Levels Following Radiation Therapy for Prostate Cancer bicalutamide, buserelin, cyproterone acetate - Prostate Cancer | Phase 3 | Completed | NCIC Clinical Trials Group | 1386 | 1999-01-05 | 2021-06-23 |
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Prostatic Neoplasms (26) · Adenocarcinoma (1) · Adrenal Hyperplasia, Congenital (1) · Neoplasm Metastasis (1) · Prostatic Intraepithelial Neoplasia (1)
Radiation Therapy Oncology Group (10) · M.D. Anderson Cancer Center (3) · NCIC Clinical Trials Group (3) · NRG Oncology (3) · Takeda (2) · Dana-Farber Cancer Institute (1) · Eastern Cooperative Oncology Group (1) · Ente Ospedaliero Ospedali Galliera (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · SWOG Cancer Research Network (1) · St. Luke's Hospital, Ireland (1) · UNICANCER (1) · VA Office of Research and Development (1)
United States (18) · Canada (13) · France (3) · Israel (2) · Puerto Rico (2) · United Kingdom (2) · Australia (1) · Belgium (1) · Chile (1) · China (1) · Colombia (1) · Ireland (1) · Italy (1) · Malta (1) · Mexico (1)
A. O. Sartor, MD (1) · Abhishek Solanki, MD MS (1) · Alan Pollack, MD, PhD (1) · Alvaro A. Martinez, MD, FACR (1) · Andrea De Censi, MD (1) · Andrew K. Lee, MD (1) · Anthony V D'Amico, M.D. Ph.D. (1) · Arif Hussain, MD (1) · Bernard M. Dubray, MD, PhD (1) · Brian Chapin (1) · Celestia S. Higano, MD (1) · Curtis A. Pettaway, MD (1) · David G. McGowan, MD (1) · Deborah P Merke, M.D. (1) · George Wilding, MD (1)
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U10CA180868 (3), P30CA016672 (2), I01CX002277 (1), U10CA180888 (1)