10 completed, 2 recruiting, 1 not yet recruiting. 13 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 10, Recruiting 2, Not yet recruiting 1 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
Follow F8 protein, human: new trials by email Literature Review of F8 protein, human trials Research Report on F8 protein, human
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Recombinant Von Willebrand Factor (rVWF) in Chinese Participants With Von Willebrand Disease (vWD) VONVENDI, ADVATE - Von Willebrand Disease (VWD) | Phase 3 | Recruiting | Takeda | 20 | 2025-10-13 | 2026-01-08 |
| Low Dose Emicizumab vs Low Dose Factor VIII in Prophylaxis in Hemophilia A Patients Emicizumab Injection, Factor VIII (FVIII) - Hemophilia A | Phase 2 / Phase 3 | Not yet recruiting | Dhaka Medical College | 20 | 2025-06-01 | 2025-04-22 |
| A Study of Vonicog Alfa (rVWF) in Children With Severe Von Willebrand Disease (vWD) Vonicog Alfa, ADVATE - Von Willebrand Disease (VWD) | Phase 3 | Recruiting | Takeda | 24 | 2024-11-06 | 2026-09-09 |
| A Study of Recombinant Von Willebrand Factor (rVWF) in Pediatric and Adult Participants With Severe Von Willebrand Disease (VWD) rVWF, rFVIII - Von Willebrand Disease (VWD) | Phase 3 | Completed | Baxalta now part of Shire | 38 | 2019-04-01 | 2025-09-03 |
| A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD) Vonicog alfa, Antihemophilic Factor (Recombinant) - Von Willebrand Disease | Phase 3 | Completed | Baxalta now part of Shire | 47 | 2017-11-06 | 2026-05-15 |
| An Open-label Safety, Efficacy and Pharmacokinetic Study of a Recombinant FVIII Compared to Recombinant Human Antihemophilic FVIII in Patients With Severe Hemophilia A rVIII-SingleChain, Octocog alfa - Hemophilia A | Phase 2 / Phase 3 | Completed | CSL Behring | 175 | 2012-02-01 | 2016-08-09 |
| BAY81-8973 Pediatric Safety and Efficacy Trial Recombinant Factor VIII (Kovaltry, BAY81-8973) - Haemophilia A | Phase 3 | Completed | Bayer | 94 | 2011-06-09 | 2023-12-05 |
| Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Subjects With Severe Hemophilia A Factor VIII (rFVIIIFc), Advate® - Severe Hemophilia A | Phase 3 | Completed | Bioverativ Therapeutics Inc. | 165 | 2010-11-01 | 2021-01-08 |
| Trial to Evaluate the Efficacy and Safety of a New Full Length Recombinant Human FVIII for Hemophilia A Recombinant Factor VIII (BAY81-8973), Recombinant Factor VIII (Kogenate FS, BAY14-2222) - Blood Coagulation Disorders, Hemophilia A | Phase 3 | Completed | Bayer | 74 | 2009-12-01 | 2016-11-28 |
| Study Evaluating On-Demand Treatment Of Xyntha In Chinese Subjects Xyntha - Hemophilia A | Phase 3 | Completed | Pfizer | 53 | 2008-09-01 | 2025-06-12 |
| Trial to Evaluate the Effect of Secondary Prophylaxis With rFVIII Therapy in Severe Hemophilia A Adult and/or Adolescent Subjects Compared to That of Episodic Treatment Recombinant Factor VIII (Kogenate FS, BAY14-2222) - Hemophilia A | Phase 3 | Completed | Bayer | 84 | 2008-03-01 | 2014-11-17 |
| Study Evaluating Prophylaxis Treatment & Characterizing Efficacy, Safety, & PK Of B-Domain Deleted Recombinant FVIII Moroctocog alfa (AF-CC) - Hemophilia A | Phase 3 | Completed | Pfizer | 66 | 2007-12-01 | 2019-01-11 |
| BAY14-2222 Continuous Infusion in Surgeries Kogenate (BAY14-2222) - Hemophilia | Phase 3 | Completed | Bayer | 15 | 2004-07-01 | 2010-04-13 |
Hemophilia A (9) · von Willebrand Diseases (4) · Blood Coagulation Disorders (1)
Bayer (4) · Baxalta now part of Shire (2) · Pfizer (2) · Takeda (2) · Bioverativ Therapeutics Inc. (1) · CSL Behring (1) · Dhaka Medical College (1)
United States (9) · Italy (7) · Austria (6) · Spain (6) · Germany (5) · United Kingdom (5) · Argentina (4) · France (4) · Israel (4) · Poland (4) · Romania (4) · Russia (4) · Turkey (Türkiye) (4) · Canada (3) · Japan (3)
Akhil R. Biswas, MBBS, FCPS (1)
PMID 26931631, PMID 23528101, PMID 24227821, PMID 25196897, PMID 25952661, PMID 26663410, PMID 27002680, PMID 27330001, PMID 27339736, PMID 27436242, PMID 27577234, PMID 28220555, PMID 28836341, PMID 29296836, PMID 30013766, PMID 31697801, PMID 32197139, PMID 33269010, PMID 33719084, PMID 36626898, PMID 37309365, PMID 38853005, PMID 39091324, PMID 39667975
2023 (2), 2008 (1), 2009 (1), 2016 (1), 2018 (1)