19 completed, 1 active not recruiting, 1 recruiting, 1 unknown. 5 Phase 3, 5 Phase 4, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 4, Unknown 1 |
| Phase 4 | 5 | Completed 4, Withdrawn 1 |
| Not applicable | 1 | Completed 1 |
Follow DPP-4 inhibitor: new trials by email Literature Review of DPP-4 inhibitor trials Research Report on DPP-4 inhibitor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Antidiabetic Medications and Risk of Cancer Metformin, sulphonylurea, DPP-4 inhibitor - Cancer | Completed | University of Pecs | 74799 | 2025-03-15 | 2026-06-05 | |
| Korean Study on Safety and Effectiveness of OAD Triple Therapy in Type 2 Diabetes SGLT2 inhibitor, Thiazolidinedione, DPP-4 inhibitor - Diabetes Mellitus, Type 2 | Recruiting | Chong Kun Dang Pharmaceutical | 10000 | 2024-01-02 | 2026-09-30 | |
| Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors Semaglutide, DPP-4 inhibitor - Diabetes | Completed | Brigham and Women's Hospital | 742670 | 2022-11-30 | 2025-11-10 | |
| Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study SGLT2 inhibitor, DPP-4 inhibitor, GLP-1RA - Cardiovascular Events, Type2 Diabetes | Active not recruiting | Brigham and Women's Hospital | 781430 | 2021-08-01 | 2026-08-13 | |
| Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease Metformin, Sulfonylurea, DPP-4 inhibitor - Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic | Completed | Weill Medical College of Cornell University | 4888 | 2019-08-01 | 2023-11-09 | |
| Replication of the EMPAREG Diabetes Trial in Healthcare Claims Empagliflozin, DPP-4 inhibitor - Diabetes | Completed | Brigham and Women's Hospital | 103752 | 2019-07-08 | 2023-07-27 | |
| Replication of the DECLARE Diabetes Trial in Healthcare Claims Dapagliflozin, DPP-4 inhibitor - Diabetes | Completed | Brigham and Women's Hospital | 49790 | 2019-07-08 | 2023-07-27 | |
| GA 6: The Blood Glucose-lowering Effect of Glucose-dependent Insulinotropic Polypeptide Placebo, GIP receptor antagonist, DPP-4 inhibitor - Type2 Diabetes | Not applicable | Completed | University Hospital, Gentofte, Copenhagen | 12 | 2019-05-29 | 2021-03-16 |
| Approaches To Therapy Escalation In T2D DPP-4 inhibitor, SGLT2 inhibitor, SGLT2 inhibitor and DPP-4 inhibitor - Type2 Diabetes | Phase 4 | Withdrawn | LMC Diabetes & Endocrinology Ltd. | 2019-05-01 | 2019-09-27 | |
| Comparative Effectiveness of Dapagliflozin Versus DPP-4 Inhibitors Dapagliflozin, DPP-4 inhibitor - Type 2 Diabetes | Completed | University of Padova | 11206 | 2018-10-18 | 2020-03-11 | |
| The Effects of Neprilysin on Glucagon-like Peptide-1 Entresto, Sitagliptin 100mg, Placebos - Diabetes, Heart Failure | Phase 4 | Completed | Nicolai Jacob Wewer Albrechtsen | 19 | 2018-05-17 | 2019-07-08 |
| Comparative Effectiveness of Empagliflozin in the US Empagliflozin, DPP-4 inhibitor, GLP-1 receptor agonist - Diabetes Mellitus, Type 2 | Completed | Boehringer Ingelheim | 230000 | 2017-10-16 | 2026-07-22 | |
| Replication of the LEADER Diabetes Trial in Healthcare Claims Liraglutide, DPP-4 inhibitor - Diabetes | Completed | Brigham and Women's Hospital | 168690 | 2017-09-22 | 2023-07-27 | |
| Replication of the CANVAS Diabetes Trial in Healthcare Claims Canagliflozin, DPP-4 inhibitor - Diabetes | Completed | Brigham and Women's Hospital | 152202 | 2017-09-22 | 2023-07-27 | |
| Comparing the Renal Effect of Dipeptidyl-peptidase 4 Inhibitors and Sulfonylureas Dipeptidyl Peptidase 4 Inhibitor, Sulfonylurea - Type 2 Diabetes Mellitus, Proteinuria | Phase 4 | Completed | Changhua Christian Hospital | 101 | 2016-03-01 | 2019-06-14 |
| A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes semaglutide, DPP-4 inhibitor - Diabetes, Diabetes Mellitus, Type 2 | Phase 3 | Completed | Novo Nordisk A/S | 601 | 2014-08-04 | 2019-01-07 |
| Off taRget Effects of Linagliptin monothErapy on Arterial Stiffness in Early Diabetes Linagliptin, placebo - Type 2 Diabetes Mellitus | Phase 3 | Completed | dr. DJ Mulder | 45 | 2014-03-01 | 2016-05-18 |
| Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis Metformin XR, Saxagliptin, Saxagliptin-Metformin XR - Polycystic Ovary Syndrome, Disorder of Glucose Regulation | Phase 3 | Completed | Woman's | 38 | 2014-03-01 | 2017-06-28 |
| Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus Vildagliptin - Type 1 Diabetes, Insulin Dependent Diabetes | Phase 3 | Unknown | Federal University of São Paulo | 44 | 2014-03-01 | 2014-05-14 |
| Efficacy and Safety of Insulin Glargine in Patients With Type 2 Diabetes With Inadequate Control on DPP-4 Inhibitor Therapy INSULIN GLARGINE, Metformin, DPP-4 inhibitor - Diabetes Mellitus, Type 2 | Phase 4 | Completed | Sanofi | 109 | 2013-12-01 | 2015-08-27 |
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Diabetes Mellitus, Type 2 (12) · Diabetes Mellitus (11) · Diabetes Mellitus, Type 1 (1) · Heart Failure (1) · Kidney Diseases (1) · Neoplasms (1) · Polycystic Ovary Syndrome (1) · Proteinuria (1) · Renal Insufficiency, Chronic (1)
Brigham and Women's Hospital (6) · Astellas Pharma Inc (1) · Boehringer Ingelheim (1) · Changhua Christian Hospital (1) · Chong Kun Dang Pharmaceutical (1) · Federal University of São Paulo (1) · LMC Diabetes & Endocrinology Ltd. (1) · Nicolai Jacob Wewer Albrechtsen (1) · Novo Nordisk A/S (1) · Royal Devon and Exeter NHS Foundation Trust (1) · Sanofi (1) · University Hospital, Gentofte, Copenhagen (1) · University of Padova (1) · University of Pecs (1) · University of Sao Paulo General Hospital (1)
United States (9) · Brazil (2) · Denmark (2) · Japan (2) · South Korea (2) · Hungary (1) · Italy (1) · Netherlands (1) · United Kingdom (1)
Shirley Wang, PhD, ScM (4) · Alvin Mushlin (1) · Andrew T Hattersley, FRCP, DM, BM (1) · Elisabetta Patorno, MD, DrPH (1) · Karen Elkind-Hirsch, Ph.D. (1) · Madhav Thambisetty, MD, PhD (1) · Maria ER Siva, MD, PhD (1) · Pieter W Kamphuisen, MD PhD (1) · Ronald M. Goldenberg, MD (1) · Shih Te Tu, MD (1)
PMID 33327727, PMID 27281773, PMID 28228317, PMID 29322610, PMID 29748996, PMID 29907893, PMID 30955357, PMID 31074791, PMID 31604171, PMID 32998732, PMID 35175317, PMID 35796651