3 recruiting, 1 completed, 1 terminated. 3 Not applicable, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Recruiting 2, Terminated 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Completed 1 |
Follow De-escalation: new trials by email Literature Review of De-escalation trials Research Report on De-escalation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Chemotherapy De-escalation in HR +, HER2-, Intermediate-risk Early Breast Cancer Treated With Adjuvant Ribociclib Chemotherapy followed by endocrine therapy and ribociclib treatment, De-escalation - Breast Cancer | Phase 3 | Recruiting | UNICANCER | 3902 | 2025-12-18 | 2026-05-26 |
| De-escalation of Radiation Dose in HPV-associated OPC Utilising FMISO PET (DE-RADIATE) De-escalation, Standard of care - HPV Positive Oropharyngeal Squamous Cell Carcinoma | Not applicable | Recruiting | Royal North Shore Hospital | 25 | 2025-04-01 | 2025-07-30 |
| The T-REX Trial: Tailored Regional External Beam Radiotherapy in Clinically Node-negative Breast Cancer Patients With 1-2 Sentinel Node Macrometastases. De-escalation - Breast Cancer | Not applicable | Recruiting | Region Skane | 1350 | 2023-03-17 | 2026-05-11 |
| Ticagrelor-based De-escalation of Dual Antiplatelet Therapy After Coronary Artery Bypass Grafting De-escalated Dual Antiplatelet Therapy, Dual Antiplatelet Therapy - Coronary Artery Disease, Coronary Artery Bypass Grafting | Phase 4 | Completed | China National Center for Cardiovascular Diseases | 2300 | 2023-02-14 | 2025-08-27 |
| A B-D-Glucan Driven Antifungal Stewardship Approach for Invasive Candidiasis De-escalation - Invasive Candidiases, Abdominal Infection | Not applicable | Terminated | University of Bologna | 34 | 2017-03-01 | 2024-08-28 |
Breast Neoplasms (2) · Angina Pectoris (1) · Candidiasis, Invasive (1) · Coronary Artery Disease (1) · Hemorrhage (1) · Hypoxia (1) · Intraabdominal Infections (1) · Myocardial Infarction (1) · Myocardial Ischemia (1)
China National Center for Cardiovascular Diseases (1) · Region Skane (1) · Royal North Shore Hospital (1) · UNICANCER (1) · University of Bologna (1)
Italy (2) · Australia (1) · China (1) · Finland (1) · France (1) · Germany (1) · Netherlands (1) · Norway (1) · Spain (1) · Sweden (1)
Anna Lawless (1) · Kai Chen (1) · Qing Chu, PhD (1) · Sara Alkner, Associate professor (1) · Sarah Bergamin (1) · Shengshou Hu, MD (1) · Xin Yuan, PhD (1)
PMID 37385747, PMID 37751948, PMID 42120081
2025 (1)