16 completed, 4 terminated, 2 recruiting. 22 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 22 | Completed 16, Terminated 4, Recruiting 2 |
| Phase 2 | 8 | Completed 6, Recruiting 1, Terminated 1 |
Follow Cyclosporin: new trials by email Literature Review of Cyclosporin trials Research Report on Cyclosporin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Assess the Effect of Sodium Zirconium Cyclosilicate on the Pharmacokinetics of Tacrolimus and Cyclosporin in Healthy Subjects Tacrolimus, Cyclosporin, Sodium Zirconium Cyclosilicate - Hyperkalaemia | Phase 1 | Completed | AstraZeneca | 62 | 2021-03-30 | 2024-04-05 |
| CLAG-M or FLAG-Ida Chemotherapy and Reduced-Intensity Conditioning Donor Stem Cell Transplant for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelomonocytic Leukemia Cladribine, Cyclophosphamide, Cyclosporine - Recurrent Acute Myeloid Leukemia, Recurrent Chronic Myelomonocytic Leukemia | Phase 1 | Recruiting | Fred Hutchinson Cancer Center | 120 | 2020-12-03 | 2026-09-17 |
| 211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia Cyclosporine, Fludarabine Phosphate, Mycophenolate Mofetil - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Phase 1 / Phase 2 | Recruiting | Fred Hutchinson Cancer Center | 75 | 2017-10-24 | 2026-06-22 |
| Brentuximab Vedotin, Cyclosporine, and Verapamil Hydrochloride in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma Brentuximab Vedotin, Cyclosporine, Pharmacokinetic Study - Recurrent Hodgkin Lymphoma, Refractory Hodgkin Lymphoma | Phase 1 | Completed | City of Hope Medical Center | 29 | 2017-05-03 | 2024-02-22 |
| Selumetinib and Cyclosporine in Treating Patients With Advanced Solid Tumors or Advanced or Metastatic Colorectal Cancer Cyclosporine, Laboratory Biomarker Analysis, Pharmacological Study - Recurrent Colorectal Carcinoma, Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 40 | 2014-08-29 | 2025-02-11 |
| Lenalidomide After Donor Stem Cell Transplant and Bortezomib in Treating Patients With High Risk Multiple Myeloma fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Refractory Multiple Myeloma, Stage I Multiple Myeloma | Phase 1 | Terminated | Case Comprehensive Cancer Center | 8 | 2013-10-07 | 2017-02-17 |
| 90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Fludarabine Phosphate - Plasma Cell Myeloma, Refractory Plasma Cell Myeloma | Phase 1 | Completed | Fred Hutchinson Cancer Center | 15 | 2012-01-09 | 2019-12-09 |
| Yttrium-90 Anti-CD45 Monoclonal Antibody BC8 Followed by Donor Stem Cell Transplant in Treating Patients With High-Risk AML, ALL, or MDS Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine - Chronic Myelomonocytic Leukemia, Previously Treated Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 16 | 2012-01-01 | 2019-12-10 |
| Dasatinib and Cyclosporine in Treating Patients With Chronic Myelogenous Leukemia Refractory or Intolerant to Imatinib Mesylate dasatinib, diagnostic laboratory biomarker analysis, pharmacological study - Accelerated Phase Chronic Myelogenous Leukemia, Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Phase 1 | Terminated | National Cancer Institute (NCI) | 4 | 2011-09-01 | 2014-04-02 |
| Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia cyclosporine, pravastatin sodium, mitoxantrone hydrochloride - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Phase 1 / Phase 2 | Terminated | Fred Hutchinson Cancer Center | 6 | 2011-04-01 | 2017-07-02 |
| A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies cyclophosphamide, fludarabine phosphate, cyclosporine - Accelerated Phase Chronic Myelogenous Leukemia, Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Phase 1 | Completed | Fred Hutchinson Cancer Center | 23 | 2006-04-01 | 2015-02-11 |
| Cyclophosphamide, Antithymocyte Globulin, and Total-Body Irradiation in Treating Patients With Severe Aplastic Anemia Undergoing Umbilical Cord Blood Transplant total-body irradiation, cyclophosphamide, anti-thymocyte globulin - Aplastic Anemia | Phase 1 | Terminated | Fred Hutchinson Cancer Center | 30 | 2006-02-01 | 2011-01-05 |
| Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 37 | 2003-09-01 | 2020-01-18 |
| Reduced-Intensity Conditioning Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myeloma fludarabine phosphate, melphalan, total-body irradiation - Refractory Multiple Myeloma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 16 | 2002-10-01 | 2017-10-16 |
| Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer total-body irradiation, fludarabine phosphate, cyclosporine - Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 21 | 2000-05-01 | 2020-01-21 |
| Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Stage IV Kidney Cancer fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation - Recurrent Renal Cell Cancer, Stage IV Renal Cell Cancer | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 11 | 2000-02-01 | 2019-07-24 |
| Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed by Unrelated Donor Stem Cell Transplant in Treating Patients With Fanconi Anemia fludarabine phosphate, cyclosporine, total-body irradiation - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 | Completed | Fred Hutchinson Cancer Center | 2 | 2000-01-01 | 2017-02-20 |
| Autologous Stem Cell Transplant Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoma Autologous Hematopoietic Stem Cell Transplantation, Autologous-Allogeneic Tandem Hematopoietic Stem Cell Transplantation, Carmustine - Prolymphocytic Leukemia, Recurrent Adult Hodgkin Lymphoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 76 | 1999-09-01 | 2020-01-29 |
| Radiolabeled Monoclonal Antibody Therapy, Fludarabine Phosphate, and Low-Dose Total-Body Irradiation Followed by Donor Stem Cell Transplant and Immunosuppression Therapy in Treating Older Patients With Advanced Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes iodine I 131 monoclonal antibody BC8, total-body irradiation, allogeneic hematopoietic stem cell transplantation - Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 | Completed | Fred Hutchinson Cancer Center | 79 | 1999-07-27 | 2019-11-13 |
| Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma melphalan, autologous hematopoietic stem cell transplantation, autologous bone marrow transplantation - Refractory Multiple Myeloma, Stage I Multiple Myeloma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 40 | 1999-03-01 | 2020-02-06 |
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Leukemia, Myeloid, Acute (7) · Multiple Myeloma (7) · Leukemia, Myelomonocytic, Chronic (6) · Congenital Abnormalities (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Anemia, Refractory, with Excess of Blasts (4) · Hodgkin Disease (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Lymphoma, Non-Hodgkin (4) · Burkitt Lymphoma (3) · Carcinoma, Renal Cell (3) · Dendritic Cell Sarcoma, Interdigitating (3) · Leukemia, Biphenotypic, Acute (3) · Leukemia, Myeloid, Accelerated Phase (3) · Leukemia, Myeloid, Chronic-Phase (3)
Fred Hutchinson Cancer Center (16) · National Cancer Institute (NCI) (2) · AstraZeneca (1) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · St. Jude Children's Research Hospital (1)
United States (21) · Italy (4) · Germany (3) · Canada (1)
Brenda Sandmaier (3) · David Maloney (3) · Alex F Herrera (1) · Ann Woolfrey (1) · Brenda M. Sandmaier (1) · Christopher H Lieu (1) · Christopher Porter (1) · Colleen Delaney (1) · Damian Green (1) · Filippo Milano (1) · Hans-Peter Kiem (1) · Hien K Liu, MD (1) · Johnnie Orozco (1) · Kimberly Kasow, DO (1) · Lauri Burroughs (1)
PMID 32499241, PMID 19786617, PMID 30335787, PMID 31582553, PMID 32710011
P30CA015704 (11), P01CA078902 (3), P01CA044991 (2), K23CA190849 (1), P01CA018029 (1), P01HL036444 (1), P30CA016672 (1), P30CA043703 (1), P30CA046934 (1), R21CA155911 (1), R24HL074445 (1), R43HL106868 (1), RC2HL101844 (1), UM1CA186644 (1), UM1CA186686 (1)